US5361767A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue characterization method and apparatus
Assignee: Individual
•
Filing: 1993-01-25
•
Granted: 1994-11-08
•
Expires: 2013-01-25
Abstract
Abstract A method and apparatus for non-invasively determining a type of tissue and its state within a living entity are disclosed. The method includes the steps of using an imaging technique to generate an image of the tissue matter to be analyzed, selecting a region of interest on the image; positioning a device for transmitting ultrasonic signals at desired frequencies in a desired location relative to the tissue matter; transmitting ultrasonic signals at at least two different frequencies through the region of interest; detecting echo signals reflected by the tissue matter; and analyzing the echo signals to determine attenuation data for the tissue matter. The apparatus includes an imaging device for generating an image of the tissue matter to be analyzed, a device for selecting the region of interest, a device for transmitting ultrasonic signals, a receiver for detecting the echo signals, a display device for displaying the echo signals, and a computer for analyzing and calculating the attenuation data.
Inventors
- 👤 Igor Yukov
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 18:37
CPC Classifications
G; G01; G01S; G01S7/00; G01S7/52; G01S7/52017; G01S7/52023; G01S7/52036; A; A61; A61B; A61B8/00; A61B8/08; A61B8/0858; G01S15/00; G01S15/88; G01S15/89; G01S15/8906; G01S15/895; G01S15/8952
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
148 words
A method for non-invasively determining a type of tissue or a state of a tissue in a living entity comprising the steps of: (a) using an imaging technique to generate an image of the tissue matter to be analyzed; (b) selecting a region of interest on said image of said tissue matter to be analyzed; (c) positioning a device for transmitting an ultrasonic signal at a desired frequency in a desired location relative to said tissue matter to be analyzed; (d) transmitting a first ultrasonic signal at a first frequency through said region of interest using said device; (e) transmitting a second ultrasonic signal at a second frequency through said region of interest using said device; (f) detecting echo signals at said first and second frequencies reflected by said tissue matter; and (g) analyzing said echo signals to determine at least one attenuation coefficient for said tissue matter.
Claim 2
Independent Claim
148 words
A method for non-invasively determining a type of tissue or a state of a tissue in a living entity comprising the steps of: (a) using an imaging technique to generate an image of the tissue matter to be analyzed; (b) selecting a region of interest on said image of said tissue matter to be analyzed; (c) positioning a device for transmitting an ultrasonic signal at a desired frequency in a desired location relative to said tissue matter to be analyzed; (d) transmitting a first ultrasonic signal at a first frequency through said region of interest using said device; (e) transmitting a second ultrasonic signal at a second frequency through said region of interest using said device; (f) detecting echo signals at said first and second frequencies reflected by said tissue matter; and (g) analyzing said echo signals to determine at least one attenuation coefficient for said tissue matter.
Claim 3
Dependent Claim
39 words
The method of claim 1 wherein said analyzing step comprises: comparing said echo signals to determine if pulses in said echo signals are aligned in time; and analyzing said reflected signals to determine if the pulses have any irregularities.
Claim 4
Dependent Claim
30 words
The method of claim 2 further comprising: (h) repositioning said device relative to said tissue matter if said pulses are misaligned or have any irregularities; and (i) repeating steps (c)-(g).
Claim 5
Dependent Claim
38 words
The method of claim 1 wherein said imaging step comprises generating a two dimensional (B-mode) image of said tissue matter to be analyzed and using said two dimensional image to determine the depth of said region of interest.
Claim 6
Dependent Claim
34 words
The method of claim 4 wherein said B-mode imaging step is performed simultaneous with said ultrasonic signal transmitting steps so as to substantially avoid anomalies caused by breathing or movement of said living entity.
Claim 7
Dependent Claim
19 words
The method of claim 4 wherein said B-mode imaging step is performed sequentially with said ultrasonic signal transmitting steps.
Claim 8
Dependent Claim
19 words
The method of claim 4 wherein said B-mode imaging step is performed alternately with said ultrasonic signal transmitting steps.
Claim 9
Dependent Claim
36 words
The method of claim 1 further comprising determining at least one of the nature of said tissue matter being examined and the state of said tissue matter being examined from said at least one attenuation coefficient.
Claim 10
Dependent Claim
58 words
The method of claim 1 wherein said analyzing step comprises: (j) matching the echo signals from a time standpoint; (k) maximizing the amplitude of the reflected signals; (l) matching the echo signals from a shape standpoint in order to compare pulse shapes; and (m) matching the echo signals from a width standpoint in order to compare pulse widths.
Claim 11
Dependent Claim
22 words
The method of claim 1 wherein said analyzing step further comprises determining frequencies from said echo signals at which errors are minimized.
Claim 12
Dependent Claim
15 words
The method of claim 1 further comprising transmitting said first and second ultrasonic signals sequentially.
Claim 13
Dependent Claim
39 words
The method of claim 1 further comprising: said transmitting steps comprising applying said first and second ultrasonic signals as a first two-frequency pair; and thereafter transmitting ultrasonic signals at a second pair of frequencies through said region of interest.
Claim 14
Dependent Claim
17 words
The method of claim 12 wherein said transmitting steps comprises transmitting said ultrasonic signals as broad-band signal.
Claim 15
Dependent Claim
28 words
The method of claim 12 wherein said second pair of frequencies transmitting step comprises transmitting a signal pair having one frequency which is in said first two-frequency pair.
Claim 16
Dependent Claim
33 words
The method of claim 1 further comprising transmitting a third ultrasonic signal at a third frequency through said region of interest spot, said third frequency being different from said first and second frequencies.
Claim 17
Dependent Claim
31 words
The method of claim 15 wherein said first, second and third signal transmitting steps comprise transmitting one broad-band signal and separating said first frequency, second frequency and third frequency signals therefrom.
Claim 18
Dependent Claim
26 words
The method of claim 15 wherein said analyzing step comprises simultaneously displaying echo signals at said first, second and third frequencies on a visual display device.
Claim 19
Dependent Claim
38 words
The method of claim 17 wherein said analyzing step further comprises determining a set of differential attenuation coefficients from said echo signals and thereafter determining said at least one attenuation coefficient from said set of differential attenuation coefficients.
Claim 20
Dependent Claim
27 words
The method of claim 1 wherein said transmitting steps comprises transmitting said ultrasonic signals as one broad-band signal and separating said signals from said one broad-band signal.
Claim 21
Dependent Claim
25 words
The method of claim 1 wherein said analyzing step is performed automatically by a computer if said frequencies are within about 2% of each other.
Claim 22
Dependent Claim
39 words
The method of claim 1 wherein said analyzing step comprises simultaneously displaying said echo signals with at least one signal having a "+ polarity" and at least one other signal having a "- polarity" on a visual display device.
Claim 23
Independent Claim
118 words
An apparatus for non-invasively determining the nature of tissue matter within a patient and/or the state of said tissue matter, said apparatus comprising: means for generating an image of said tissue matter; means for selecting a region of interest on said generated image of said tissue matter to be analyzed; a transducer for transmitting ultrasonic signals having at least two different frequencies through said region of interest; means for detecting echo signals created by ultrasonic signals at said different frequencies passing through and being reflected by said tissue matter; and means for analyzing said echo signals at said different frequencies and determining at least one attenuation coefficient for said tissue matter from the analysis of said echo signals.
Claim 24
Independent Claim
118 words
An apparatus for non-invasively determining the nature of tissue matter within a patient and/or the state of said tissue matter, said apparatus comprising: means for generating an image of said tissue matter; means for selecting a region of interest on said generated image of said tissue matter to be analyzed; a transducer for transmitting ultrasonic signals having at least two different frequencies through said region of interest; means for detecting echo signals created by ultrasonic signals at said different frequencies passing through and being reflected by said tissue matter; and means for analyzing said echo signals at said different frequencies and determining at least one attenuation coefficient for said tissue matter from the analysis of said echo signals.
Claim 25
Dependent Claim
16 words
The apparatus of claim 22 wherein said imaging means comprises means for creating a two-dimensional image.
Claim 26
Dependent Claim
19 words
The apparatus of claim 23 wherein said transducer is used to transmit ultrasonic signals for generating said two-dimensional image.
Claim 27
Dependent Claim
17 words
The apparatus of claim 22 wherein said analyzing means includes means for visually displaying said echo signals.
Claim 28
Dependent Claim
15 words
The apparatus of claim 25 wherein said visual display means comprises an A-mode display device.
Claim 29
Dependent Claim
54 words
The apparatus of claim 25 further comprising; a pulse generator for generating a first ultrasonic pulse at a first frequency and a second ultrasonic pulse at a second frequency, said second frequency being different than from said first frequency; and said visual display means simultaneously displaying echo pulses at said first and second frequencies.
Claim 30
Dependent Claim
37 words
The apparatus of claim 27 wherein said pulse generator generates a third ultrasonic pulse at a third frequency and said visual display means simultaneously displaying echo pulse waves at each of said first, second and third frequencies.
Claim 31
Dependent Claim
19 words
The apparatus of claim 27 wherein said pulse generator generates said first and second pulses as one broad-band signal.
Claim 32
Dependent Claim
16 words
The apparatus of claim 27 wherein said pulse generator generates said pulses as a multi-frequency pair.
Claim 33
Dependent Claim
39 words
The apparatus of claim 22 further comprising: means for converting said echo pulse signals from analog signals into digital signals; and said analyzing means including programmed computer means for determining said attenuation coefficients from said digital echo pulse signals.
Claim 34
Dependent Claim
42 words
The apparatus of claim 22 further comprising: a control panel unit for allowing an operator to select said region of interest on said image generated by said generating means and for selecting the frequencies at which said transducer generates said ultrasonic pulses.
Claim 35
Dependent Claim
39 words
The apparatus of claim 32 further comprising: said control panel having switch means for allowing said operator to transmit said ultrasonic signals simultaneous with said image generation, in sequence with said image generation, or alternative with said image generation.
Claim 36
Independent Claim
139 words
A method for non-invasively determining a type of matter or a state of said matter comprising the steps of: (a) using an imaging technique to generate an image of the matter to be analyzed; (b) selecting a region of interest on said image of said matter to be analyzed; (c) positioning a device for transmitting a wave signal at a desired frequency in a desired location relative to said matter to be analyzed; (d) transmitting a first wave signal at a first frequency through said region of interest using said device; (e) transmitting a second wave signal at a second frequency through said region of interest using said device; (f) detecting echo signals at said first and second frequencies reflected by said matter; and (g) analyzing said echo signals to determine at least one attenuation coefficient for said matter.
Claim 37
Independent Claim
139 words
A method for non-invasively determining a type of matter or a state of said matter comprising the steps of: (a) using an imaging technique to generate an image of the matter to be analyzed; (b) selecting a region of interest on said image of said matter to be analyzed; (c) positioning a device for transmitting a wave signal at a desired frequency in a desired location relative to said matter to be analyzed; (d) transmitting a first wave signal at a first frequency through said region of interest using said device; (e) transmitting a second wave signal at a second frequency through said region of interest using said device; (f) detecting echo signals at said first and second frequencies reflected by said matter; and (g) analyzing said echo signals to determine at least one attenuation coefficient for said matter.
Claim 38
Independent Claim
98 words
An apparatus for non-invasively determining the nature of matter and/or the state of said matter, said apparatus comprising: means for generating an image of said matter; means for selecting a region of interest on said generated image of said matter to be analyzed; means for transmitting wave signals at desired frequencies through said region of interest; means for detecting echo signals created by said wave signals passing through and being reflected by said matter; and means for analyzing said echo signals and determining at least one attenuation coefficient for said matter from the analysis of said echo signals.
Claim 39
Independent Claim
98 words
An apparatus for non-invasively determining the nature of matter and/or the state of said matter, said apparatus comprising: means for generating an image of said matter; means for selecting a region of interest on said generated image of said matter to be analyzed; means for transmitting wave signals at desired frequencies through said region of interest; means for detecting echo signals created by said wave signals passing through and being reflected by said matter; and means for analyzing said echo signals and determining at least one attenuation coefficient for said matter from the analysis of said echo signals.
Claim 40
Independent Claim
106 words
A method for non-invasively determining a type of earthen material or a state of said material comprising the steps of: (a) positioning a device for transmitting a wave signal at a desired frequency in a desired location relative to said material to be analyzed; (b) transmitting a first wave signal at a first frequency through said material using said device; (c) transmitting a second wave signal at a second frequency through said material using said device; (d) detecting echo signals at said first and second frequencies reflected by said material; and (e) analyzing said echo signals to determine at least one attenuation coefficient for said material.
Claim 41
Independent Claim
106 words
A method for non-invasively determining a type of earthen material or a state of said material comprising the steps of: (a) positioning a device for transmitting a wave signal at a desired frequency in a desired location relative to said material to be analyzed; (b) transmitting a first wave signal at a first frequency through said material using said device; (c) transmitting a second wave signal at a second frequency through said material using said device; (d) detecting echo signals at said first and second frequencies reflected by said material; and (e) analyzing said echo signals to determine at least one attenuation coefficient for said material.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-11-07 | 1998-05-09 | 1998-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-11-07 | 2002-05-09 | 2002-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-11-07 | 2006-05-09 | 2006-11-08 | $7700.00 | Window Closed / Lapsed |