US5358475A
Expired / Lapsed
US
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High molecular weight bioresorbable polymers and implantable devices thereof
Assignee: United States Surgical Corp
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Filing: 1992-09-28
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Granted: 1994-10-25
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Expires: 2012-09-28
Abstract
Abstract Nerve channels made from high molecular weight lactic acid polymers, preferably polymers having a molecular weight between about 234,000 and 320,000, provide an unexpectedly beneficial effect on cell growth and regeneration of function.
Inventors
- 👤 Frank Mares
- 👤 Reginald T. Tang
- 👤 Tin-Ho Chiu
- 👤 Theodore Largman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:19
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61B; A61B17/00; A61B17/11; A61B17/1128; A61L27/14; A61L27/18; A61L27/28; A61L27/34; A61B2017/00004; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2002/30001; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2230/00; A61F2230/0063; A61F2230/0069; A61L2430/00; A61L2430/32
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
49 words
In a nerve channel suitable for implantation into a living organism and in the form of a tube, the improvement which comprises that at least a portion of said nerve channel is comprised of a homopolymer of poly(DL-lactide) having an average molecular weight of between about 234,000 and 320,000.
Claim 2
Dependent Claim
49 words
In a nerve channel suitable for implantation into a living organism and in the form of a tube, the improvement which comprises that at least a portion of said nerve channel is comprised of a homopolymer of poly(DL-lactide) having an average molecular weight of between about 234,000 and 320,000.
Claim 3
Dependent Claim
28 words
A nerve channel comprising a tube comprising a polymer consisting essentially of lactice acid ester linkages said polymer having an average molecular weight between about 234,000 and 320,000.
Claim 4
Dependent Claim
28 words
A nerve channel comprising a tube comprising a polymer consisting essentially of lactice acid ester linkages said polymer having an average molecular weight between about 234,000 and 320,000.
Claim 5
Dependent Claim
25 words
The nerve channel of claim 2 wherein the polymer has a narrow molecular weight distribution characterized by a dispersity number of less than about 10.0.
Claim 6
Dependent Claim
25 words
The nerve channel of claim 2 wherein the polymer has a narrow molecular weight distribution characterized by a dispersity number of less than about 3.0.
Claim 7
Dependent Claim
29 words
The nerve channel of claim 2 wherein the polymer has a narrow molecular weight distribution characterized by a dispersity number in the range of about 1.0 to about 1.9.
Claim 8
Dependent Claim
17 words
The nerve channel of claim 2 wherein at least one biocompatible plasticizer is included in the polymer.
Claim 9
Dependent Claim
17 words
The nerve channel of claim 2 wherein the nerve channel further comprises one or more biodurable materials.
Claim 10
Dependent Claim
23 words
The nerve channel of claim 1 wherein the polymer has narrow molecular weight distribution characterized by a dispersity number of less than 10.0.
Claim 11
Dependent Claim
15 words
The nerve channel of claim 8 wherein the dispersity number is less than about 3.0.
Claim 12
Dependent Claim
14 words
The device of claim 1 wherein the bioresorbable polymer is the homopolymer poly (DL-lactide).
Claim 13
Dependent Claim
17 words
The nerve channel of claim 1 wherein at least one biocompatible plasticizer is included in the polymer.
Claim 14
Dependent Claim
18 words
The nerve channel of claim 1 wherein the bioresorbable polymer is mixed with one or more biodurable materials.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-24 | 1998-04-25 | 1998-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-24 | 2002-04-25 | 2002-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-24 | 2006-04-25 | 2006-10-25 | $7700.00 | Window Closed / Lapsed |