US5356928A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cytotoxic agents
Assignee: Hauser Chemical Research Inc
•
Filing: 1993-09-17
•
Granted: 1994-10-18
•
Expires: 2013-09-17
Abstract
Abstract The invention relates to pharmaceutical compositions comprising an effective cytotoxic amount of: ##STR1## Wherein R represents Ac or H; R' represents: ##STR2## OH; and R" represents: ##STR3## these new compounds demonstrate surprising tubulin binding activity and cytotoxicity.
Inventors
- 👤 Christopher K. Murray
- 👤 David T. Bailey
- 👤 S. Kent Peterson
- 👤 Jeffrey T. Beckvermit
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:34
CPC Classifications
C; C07; C07D; C07D407/00; C07D407/02; C07D407/12; A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/337; A61K31/357; C07D305/00; C07D305/14; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/256
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
29 words
A pharmaceutical composition comprising a carrier and an effective cytotoxic amount of the compound: ##STR13## Wherein R represents Ac or H; R' represents: ##STR14## OH; and R" represents: ##STR15##
Claim 2
Dependent Claim
29 words
A pharmaceutical composition comprising a carrier and an effective cytotoxic amount of the compound: ##STR13## Wherein R represents Ac or H; R' represents: ##STR14## OH; and R" represents: ##STR15##
Claim 3
Dependent Claim
17 words
The pharmaceutical composition of claim 1 wherein: R is Ac; R' is: ##STR16## and R" is: ##STR17##
Claim 4
Dependent Claim
17 words
The pharmaceutical composition of claim 1 wherein: R is H; R' is: ##STR18## and R" is: ##STR19##
Claim 5
Dependent Claim
17 words
The pharmaceutical composition of claim 1 wherein: R is H; R' is: ##STR20## and R" is: ##STR21##
Claim 6
Dependent Claim
17 words
The pharmaceutical composition of claim 1 wherein: R is H; R' is: ##STR22## and R" is: ##STR23##
Claim 7
Dependent Claim
17 words
The pharmaceutical composition of claim 1 wherein: R is H; R' is: ##STR24## and R" is: ##STR25##
Claim 8
Dependent Claim
17 words
The pharmaceutical composition of claim 1 wherein: R is Ac; R' is: ##STR26## and R" is: ##STR27##
Claim 9
Dependent Claim
17 words
The pharmaceutical composition of claim 1 wherein: R is Ac; R' is: ##STR28## and R" is: ##STR29##
References Cited (Backward Citations)
US5200534A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-17 | 1998-04-18 | 1998-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-17 | 2002-04-18 | 2002-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-17 | 2006-04-18 | 2006-10-18 | $7700.00 | Window Closed / Lapsed |