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US5350375A Expired / Lapsed US ⏱️ 0.0 years remaining

Methods for laser induced fluorescence intensity feedback control during laser angioplasty

Assignee: Yale University
•
Filing: 1993-03-15
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Granted: 1994-09-27
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Expires: 2013-03-15
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Abstract

Abstract Methods are provided for laser induced fluorescence intensity feedback and control during laser angioplasty. In a first aspect of the invention, a catheter including an eccentric guidewire lumen and at least one optical fiber is positioned relative to an obstruction in a blood vessel by rotating the catheter and monitoring the fluorescence intensity. When the fluorescence intensity has a maximum value, the optical fiber is aligned with the obstruction. In another aspect of the invention, fluorescence intensity feedback is used to determine when a laser ablation device has crossed an occlusion. An abrupt drop in fluorescence intensity indicates that the ablation device has crossed the occlusion. In a further aspect of the invention, fluorescence intensity feedback is used to determine the effectiveness of fluid flushing in a blood vessel. In yet another aspect of the invention, fluorescence spectroscopy and fluorescence intensity monitoring are performed sequentially for different subsets of optical fibers in a laser catheter to provide precise control over fiber positioning, tissue diagnosis and ablation. Preferably, the fluorescence intensity feedback is used in conjunction with fluorescence spectroscopy.

Inventors

  • 👤 Lawrence I. Deckelbaum
  • 👤 John J. Scott

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 19:18
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B18/24; A61B18/245; A61B17/00; A61B2017/00017; A61B2017/00022; A61B2017/00057; A61B2017/00061

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 132 words
A method for controlling the effectiveness of fluid flushing in a blood vessel, comprising the steps of: advancing a catheter through a blood vessel to a region of interest, said catheter including an optical fiber extending therethrough; introducing a flushing fluid into the region of interest in the blood vessel; stimulating fluorescence from material in the region of interest adjacent to the distal end of said optical fiber by transmitting through said optical fiber laser radiation having a wavelength and intensity to stimulate such fluorescence; monitoring the intensity of the fluorescence from material in the region of interest; and increasing the amount of flushing fluid in the region of interest if the intensity of said fluorescence is representative of less than a desired amount of flushing fluid in the region of interest.
Claim 2
Independent Claim 132 words
A method for controlling the effectiveness of fluid flushing in a blood vessel, comprising the steps of: advancing a catheter through a blood vessel to a region of interest, said catheter including an optical fiber extending therethrough; introducing a flushing fluid into the region of interest in the blood vessel; stimulating fluorescence from material in the region of interest adjacent to the distal end of said optical fiber by transmitting through said optical fiber laser radiation having a wavelength and intensity to stimulate such fluorescence; monitoring the intensity of the fluorescence from material in the region of interest; and increasing the amount of flushing fluid in the region of interest if the intensity of said fluorescence is representative of less than a desired amount of flushing fluid in the region of interest.
Claim 3
Dependent Claim 40 words
A method as defined in claim 1 wherein the step of increasing the amount of flushing fluid is performed until the fluorescence intensity exceeds a predetermined value representative of the desired amount of flushing fluid in the region of interest.
Claim 4
Dependent Claim 27 words
A method as defined in claim 2 wherein the step of monitoring the fluorescence intensity includes monitoring the sum of fluorescence intensities at two or more wavelengths.
Claim 5
Dependent Claim 30 words
A method as defined in claim 3 wherein the step of monitoring the sum of fluorescence intensities includes monitoring the sum of fluorescence intensities at 380 nanometers and 440 nanometers.
Claim 6
Dependent Claim 24 words
A method as defined in claim 2 wherein the step of monitoring the fluorescence intensity includes monitoring the fluorescence intensity near a single wavelength.
Claim 7
Dependent Claim 24 words
A method as defined in claim 5 wherein the step of monitoring the fluorescence intensity near a single wavelength is performed near 380 nanometers.
Claim 8
Dependent Claim 29 words
A method as defined in claim 1 wherein the step of increasing the amount of flushing fluid includes increasing a rate of fluid flow to the region of interest.
Claim 9
Dependent Claim 26 words
A method as defined in claim 1 wherein the step of increasing the amount of flushing fluid includes introducing additional fluid into the region of interest.
Claim 10
Dependent Claim 20 words
A method as defined in claim 1 wherein said flushing fluid is substantially transparent to the fluorescence wavelengths of interest.
Claim 11
Dependent Claim 13 words
A method as defined in claim 1 wherein said flushing fluid comprises saline.
Claim 12
Dependent Claim 26 words
A method as defined in claim 1 wherein the step of stimulating fluorescence includes transmitting laser radiation in a wavelength range of 280 to 400 nanometers.

References Cited (Backward Citations)

US4718417A Cited
US5106387A Cited
US4785806A Cited
US5115137A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1997-09-26 1998-03-28 1998-09-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2001-09-26 2002-03-28 2002-09-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2005-09-26 2006-03-28 2006-09-27 $7700.00 Window Closed / Lapsed

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