US5349294A
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US
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Two and three-dimensionally selective RF pulses for magnetic resonance imaging
Assignee: Philips Nuclear Medicine Inc
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Filing: 1993-05-12
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Granted: 1994-09-20
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Expires: 2013-05-12
Abstract
Abstract A sequence controller (30) controls gradient pulse amplifiers (20) and a digital transmitter (24) to apply a conventional magnetic resonance imaging or spectroscopy sequence. One or more of the resonance excitation pulses includes a series of very small tip angle RF pulses (52, 70) applied in rapid succession substantially within the time interval of a normal RF excitation pulse (e.g. 10 msec.). A series of gradient pulses (58x, 58y, 72y, 72z) with linearly diminishing amplitudes and a repetition cycle that is an integer multiple of the duration of the very small tip angle RF pulses are applied such that an excitation trajectory in k-space follows a piecewise linear square spiral (FIG. 3 ) when gradients are applied along two axes or an octahedral spiral (FIG. 6 ) when a series of gradient pulses are applied along three axes. The subregion of resonance excitation is selectively shifted along one of the axes by applying a series of frequency offset pulses (66, 76) along one or more of the axes. In this manner, the position of the subregion of resonance excitation is shifted without changing the phase component of the RF pulses.
Inventors
- 👤 Larry Kasuboski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:43
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/446
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
89 words
A method of exciting magnetic resonance in a limited subregion of an examination region, the method comprising: creating a static magnetic field through an examination region; concurrently transmitting a series of temporally contiguous radio frequency pulses and excitation select gradient pulses into the examination region, the series of contiguous radio frequency pulses taken together control a magnetic resonance excitation tip angle, the excitation select gradient pulse and the radio frequency pulses interact to cause magnetic resonance to be excited along a k-space trajectory that follows a piecewise linear spiral.
Claim 2
Independent Claim
89 words
A method of exciting magnetic resonance in a limited subregion of an examination region, the method comprising: creating a static magnetic field through an examination region; concurrently transmitting a series of temporally contiguous radio frequency pulses and excitation select gradient pulses into the examination region, the series of contiguous radio frequency pulses taken together control a magnetic resonance excitation tip angle, the excitation select gradient pulse and the radio frequency pulses interact to cause magnetic resonance to be excited along a k-space trajectory that follows a piecewise linear spiral.
Claim 3
Dependent Claim
45 words
The method as set forth in claim 1 further including applying a series of frequency offset profiles generally concurrent with the excitation select gradient pulses along a first axis, amplitudes of the frequency offset pulses controlling shifting of the excitation subregion along the firs axis.
Claim 4
Dependent Claim
19 words
The method as set forth in claim 2 wherein the series of frequency offset profiles diminish in amplitude linearly.
Claim 5
Dependent Claim
31 words
The method as set forth in claim 3 wherein the excitation select gradient pulses are applied along three mutually orthogonal axes such that the trajectory follows a three-dimensional piecewise linear spiral.
Claim 6
Dependent Claim
17 words
The method as set forth in claim 4 wherein the k-space trajectory follows along an octahedral spiral.
Claim 7
Dependent Claim
83 words
The method as set forth in claim 1 wherein each radio frequency pulse of the series of radio frequency pulses has the same duration and wherein the excitation select gradient pulses include: x-gradient pulses which oscillate in polarity with a periodicity such that each cycle of the x-gradient pulses is an integer multiple of radio frequency pulses; and y-gradient pulses which oscillate in polarity with a periodicity such that each cycle of the y-gradient pulses is an integer multiple of radio frequency pulses.
Claim 8
Dependent Claim
18 words
The method as set forth in claim 6 wherein the x and y-gradient pulses diminish linearly in amplitude.
Claim 9
Dependent Claim
81 words
The method as set forth in claim 7 further including displacing the limited subregion along one of the first and second axes by applying a positive frequency offset profile of a positive polarity concurrently with each positive gradient pulse along the selected axis and applying a negative frequency offset profile concurrently with each excitation select gradient pulse along the selected axis, the positive and negative frequency offset profiles each having substantially the same duration as one of the radio frequency pulses.
Claim 10
Dependent Claim
23 words
The method as set forth in claim 8 wherein the series of excitation select gradient pulses further includes a series of z-gradient pulses.
Claim 11
Dependent Claim
46 words
The method as set forth in claim 7 wherein the excitation select gradient pulses include a series of z-gradient pulses, the z-gradient pulses cyclically alternating polarity with a periodicity which is an integer ratio of the radio frequency pulses, the z-gradient pulses diminishing linearly in amplitude.
Claim 12
Independent Claim
240 words
A method of exciting magnetic resonance in a limited subregion of an examination region, the method comprising: creating a static magnetic field through an examination region; concurrently transmitting a series of radio frequency pulses and excitation location selection gradient pulses into the examination region, the radio frequency pulses each having a common duration and being immediately temporally contiguous such that the combination of the radio frequency pulses taken together control a magnetic resonance tip angle, the series of excitation location selection pulses including a series of x-gradient pulses including positive and negative x-gradient pulses having a fixed cyclic periodicity, which x-gradient periodicity is an integer multiple of the radio frequency pulses, the x-gradient pulses having amplitudes which diminish linearly over a temporal duration of the radio frequency pulse series, a series of y-gradient pulses including positive and negative y-gradient pulses having a fixed cyclic periodicity, which y-gradient periodicity is an integer multiple of the radio frequency pulses, the y-gradient pulses having amplitudes which diminish linearly over the temporal duration of the radio frequency pulse series, a series of z-gradient pulses including positive and negative z-gradient pulses having a fixed cyclic periodicity, which z-gradient periodicity is an integer multiple of the periodicity of the radio frequency pulses, the z-gradient pulses having amplitudes which diminish linearly over the temporal duration of the radio frequency pulse series, whereby magnetic resonance is excited along a k-space trajectory which spirals symmetrically inward in three dimensions.
Claim 13
Independent Claim
240 words
A method of exciting magnetic resonance in a limited subregion of an examination region, the method comprising: creating a static magnetic field through an examination region; concurrently transmitting a series of radio frequency pulses and excitation location selection gradient pulses into the examination region, the radio frequency pulses each having a common duration and being immediately temporally contiguous such that the combination of the radio frequency pulses taken together control a magnetic resonance tip angle, the series of excitation location selection pulses including a series of x-gradient pulses including positive and negative x-gradient pulses having a fixed cyclic periodicity, which x-gradient periodicity is an integer multiple of the radio frequency pulses, the x-gradient pulses having amplitudes which diminish linearly over a temporal duration of the radio frequency pulse series, a series of y-gradient pulses including positive and negative y-gradient pulses having a fixed cyclic periodicity, which y-gradient periodicity is an integer multiple of the radio frequency pulses, the y-gradient pulses having amplitudes which diminish linearly over the temporal duration of the radio frequency pulse series, a series of z-gradient pulses including positive and negative z-gradient pulses having a fixed cyclic periodicity, which z-gradient periodicity is an integer multiple of the periodicity of the radio frequency pulses, the z-gradient pulses having amplitudes which diminish linearly over the temporal duration of the radio frequency pulse series, whereby magnetic resonance is excited along a k-space trajectory which spirals symmetrically inward in three dimensions.
Claim 14
Dependent Claim
44 words
The method as set forth in claim 11 further including applying a series of frequency offset profiles concurrently with gradient pulses of a selected one of the x, y, and z-gradient pulse series to displace the limited region of excitation along the selected axis.
Claim 15
Dependent Claim
32 words
The method as set forth in claim 12 further including adjusting the amplitude of the frequency offset profile to control a distance along the selected axis which the limited subregion is displaced.
Claim 16
Dependent Claim
28 words
The method as set forth in claim 12 wherein the series of frequency offset profiles diminish linearly in amplitude over the duration of the radio frequency pulse series.
Claim 17
Independent Claim
175 words
A method of exciting magnetic resonance in a limited subregion of an examination region, the method comprising: creating a static magnetic field through an examination region; concurrently transmitting a series of temporally contiguous radio frequency pulses having a radio frequency pulse series periodicity and applying a series of excitation subregion selection gradient pulses into the examination region along at least first and second axes, the series of excitation subregion selection gradient pulses having a periodicity which is an integer multiple of the radio frequency pulse series periodicity, the series of contiguous radio frequency pulses and the series of excitation subregion selection gradient pulses interacting to cause magnetic resonance to be excited along a k-space trajectory that follows a piecewise linear spiral; displacing the selected subregion within which magnetic resonance is excited along a selected one of the axes by applying a frequency offset profile concurrently with each excitation subregion selection gradient pulse along the selected axis, each frequency offset profile being concurrently with and having the same duration as one the radio frequency pulse pulses.
Claim 18
Independent Claim
175 words
A method of exciting magnetic resonance in a limited subregion of an examination region, the method comprising: creating a static magnetic field through an examination region; concurrently transmitting a series of temporally contiguous radio frequency pulses having a radio frequency pulse series periodicity and applying a series of excitation subregion selection gradient pulses into the examination region along at least first and second axes, the series of excitation subregion selection gradient pulses having a periodicity which is an integer multiple of the radio frequency pulse series periodicity, the series of contiguous radio frequency pulses and the series of excitation subregion selection gradient pulses interacting to cause magnetic resonance to be excited along a k-space trajectory that follows a piecewise linear spiral; displacing the selected subregion within which magnetic resonance is excited along a selected one of the axes by applying a frequency offset profile concurrently with each excitation subregion selection gradient pulse along the selected axis, each frequency offset profile being concurrently with and having the same duration as one the radio frequency pulse pulses.
Claim 19
Dependent Claim
27 words
The method as set forth in claim 15 further including adjusting the amplitude of the frequency offset profile to adjust a displacement distance along the selected axis
Claim 20
Dependent Claim
36 words
The method as set forth in claim 16 wherein the amplitudes of the excitation subregion selection gradient pulses and the frequency offset profile diminish linearly over the duration of the series of radio frequency pulse series.
Claim 21
Dependent Claim
97 words
The method as set forth in claim 16 wherein the step of applying the series of excitation location selection gradient pulses further includes cyclically applying gradient pulses along a third axis with a cyclic periodicity which is the same integer multiple of the radio frequency pulse series periodicity as the cyclic periodicity of the gradient pulses along the first and second axes, the radio frequency pulses and the excitation subregion selection gradient pulses along the three axes being selected such that the magnetic resonance is excited along a k-space trajectory which follows a three-dimensional piecewise linear spiral.
Claim 22
Independent Claim
100 words
An apparatus for exciting magnetic resonance in a limited subregion of an examination region, the apparatus comprising: a means for creating a static magnetic field through an examination region; a means for concurrently transmitting a series of temporally contiguous radio frequency pulses and for applying a series of excitation location selection gradient pulses along at least first and second orthogonal axes into the examination region such that the series of radio frequency pulses and the series of excitation location selection gradient pulses interact to cause magnetic resonance to be excited along a k-space trajectory that follows a piecewise linear spiral.
Claim 23
Independent Claim
100 words
An apparatus for exciting magnetic resonance in a limited subregion of an examination region, the apparatus comprising: a means for creating a static magnetic field through an examination region; a means for concurrently transmitting a series of temporally contiguous radio frequency pulses and for applying a series of excitation location selection gradient pulses along at least first and second orthogonal axes into the examination region such that the series of radio frequency pulses and the series of excitation location selection gradient pulses interact to cause magnetic resonance to be excited along a k-space trajectory that follows a piecewise linear spiral.
Claim 24
Independent Claim
205 words
An apparatus for exciting magnetic resonance in a limited subregion of an examination region, the apparatus comprising: a means for creating a static magnetic field through an examination region; means for transmitting a series of radio frequency pulses into the examination region, the radio frequency pulses each having a common duration and being immediately temporally contiguous such that the combination of the radio frequency pulses taken together control a magnetic resonance tip angle; a means for applying excitation subregion selection gradient pulses across the examination region, the series of excitation subregion selection pulses including a series of x-gradient pulses including positive and negative x-gradient pulses, a series of y-gradient pulses including positive and negative y-gradient pulses and a series of z-gradient pulses including positive and negative z-gradient pulses; a control means for controlling the means for transmitting radio frequency pulses and the gradient applying means such that the x, y, and z-gradient pulse series have a periodicity which is an integer multiple of the radio frequency pulse duration, the x, y, and z-gradient pulses having amplitudes which diminish linearly over the temporal duration of the radio frequency pulse series, whereby magnetic resonance is excited along a k-space trajectory which spirals symmetrically inward in three dimensions.
Claim 25
Independent Claim
205 words
An apparatus for exciting magnetic resonance in a limited subregion of an examination region, the apparatus comprising: a means for creating a static magnetic field through an examination region; means for transmitting a series of radio frequency pulses into the examination region, the radio frequency pulses each having a common duration and being immediately temporally contiguous such that the combination of the radio frequency pulses taken together control a magnetic resonance tip angle; a means for applying excitation subregion selection gradient pulses across the examination region, the series of excitation subregion selection pulses including a series of x-gradient pulses including positive and negative x-gradient pulses, a series of y-gradient pulses including positive and negative y-gradient pulses and a series of z-gradient pulses including positive and negative z-gradient pulses; a control means for controlling the means for transmitting radio frequency pulses and the gradient applying means such that the x, y, and z-gradient pulse series have a periodicity which is an integer multiple of the radio frequency pulse duration, the x, y, and z-gradient pulses having amplitudes which diminish linearly over the temporal duration of the radio frequency pulse series, whereby magnetic resonance is excited along a k-space trajectory which spirals symmetrically inward in three dimensions.
Claim 26
Independent Claim
194 words
An apparatus for exciting magnetic resonance in a limited subregion of an examination region, the apparatus comprising: a means for creating a static magnetic field through an examination region; a means for transmitting a series of temporally contiguous radio frequency pulses each of a common duration into the examination region; a means for applying a series of limited subregion selection gradient pulses across the examination region along at least two axes; a control means for controlling the radio frequency transmitting means and the gradient applying means such that the series of limited subregion selection gradient pulses have a periodicity which is an integer multiple of the common duration of the radio frequency pulses, the series of contiguous radio frequency pulses and the series of limited subregion selection gradient pulses interacting to cause magnetic resonance to be excited along a k-space trajectory that follows a piecewise linear spiral; a means for displacing the limited subregion along a selected one of the axes, the displacing means controlling the gradient applying means and the radio frequency pulse transmitting means to apply an offset gradient pulse concurrently with each limited subregion selection gradient pulse along the selected axis.
Claim 27
Independent Claim
194 words
An apparatus for exciting magnetic resonance in a limited subregion of an examination region, the apparatus comprising: a means for creating a static magnetic field through an examination region; a means for transmitting a series of temporally contiguous radio frequency pulses each of a common duration into the examination region; a means for applying a series of limited subregion selection gradient pulses across the examination region along at least two axes; a control means for controlling the radio frequency transmitting means and the gradient applying means such that the series of limited subregion selection gradient pulses have a periodicity which is an integer multiple of the common duration of the radio frequency pulses, the series of contiguous radio frequency pulses and the series of limited subregion selection gradient pulses interacting to cause magnetic resonance to be excited along a k-space trajectory that follows a piecewise linear spiral; a means for displacing the limited subregion along a selected one of the axes, the displacing means controlling the gradient applying means and the radio frequency pulse transmitting means to apply an offset gradient pulse concurrently with each limited subregion selection gradient pulse along the selected axis.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-09-19 | 1998-03-21 | 1998-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-19 | 2002-03-21 | 2002-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-19 | 2006-03-21 | 2006-09-20 | $7700.00 | Window Closed / Lapsed |