US5346702A
Expired / Lapsed
US
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Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
Assignee: PARTICULATE PROSPECTS CORP
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Filing: 1992-12-04
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Granted: 1994-09-13
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Expires: 2012-12-04
Abstract
Abstract This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and a non-ionic cloud point modifier associated therewith, which cloud point modifier is present in an amount-sufficient to increase the cloud point of the surface modifier. A preferred surface modifier is a poloxamine such as Tetronic 908, and preferred non-ionic cloud point modifiers include polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin and/or glycerol. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and a non-ionic cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.
Inventors
- 👤 George C. Na
- 👤 Natarajan Rajagopalan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 00:32
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6921; A61K47/6927; A61K47/6929; A61K47/6923; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0476; A61K49/0485; A61K49/049; A61K9/00; A61K9/14; A61K9/141; A61K9/146; B; B82; B82Y; B82Y5/00; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/734; Y10S977/742; Y10S977/745; Y10S977/773; Y10S977/84; Y10S977/842; Y10S977/847; Y10S977/902; Y10S977/904; Y10S977/915
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
83 words
A composition comprised of nanoparticles containing a diagnostic or having a nonionic surfactant as a surface modifier adsorbed on the surface thereof and a non-ionic cloud point modifier associated therewith, which cloud point modifier is present in an amount of 0.01-50 % by weight based on the total weight of the composition and sufficient to increase the cloud point of the surface modifier wherein said nanoparticles are resistant to size growth when said composition is heat sterilized at 121° C. for 15 minutes.
Claim 2
Dependent Claim
83 words
A composition comprised of nanoparticles containing a diagnostic or having a nonionic surfactant as a surface modifier adsorbed on the surface thereof and a non-ionic cloud point modifier associated therewith, which cloud point modifier is present in an amount of 0.01-50 % by weight based on the total weight of the composition and sufficient to increase the cloud point of the surface modifier wherein said nanoparticles are resistant to size growth when said composition is heat sterilized at 121° C. for 15 minutes.
Claim 3
Dependent Claim
12 words
The composition of claim 1 wherein said nanoparticles contain a diagnostic agent.
Claim 4
Dependent Claim
12 words
The composition of claim 2 wherein said diagnostic agent is ethyl 3,5-diacetoamido-2,4,6-triiodobenzoate.
Claim 5
Dependent Claim
108 words
A composition comprised of nanoparticles containing a diagnostic or therapeutic agent having a nonionic surfactant as a surface modifier adsorbed on the surface thereof and a nonionic cloud point modifier associated therewith, which cloud point modifier is selected from the group consisting of polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin, and glycerol and is present in an amount of 0.01-50% by weight based on the total weight of the composition and sufficient to increase the cloud point of the surface modifier above the sterilization temperature of the nanoparticles, wherein said nanoparticles are resistant to particle size growth when said composition is heat sterilized at 121° C. for 15 minutes.
Claim 6
Dependent Claim
108 words
A composition comprised of nanoparticles containing a diagnostic or therapeutic agent having a nonionic surfactant as a surface modifier adsorbed on the surface thereof and a nonionic cloud point modifier associated therewith, which cloud point modifier is selected from the group consisting of polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin, and glycerol and is present in an amount of 0.01-50% by weight based on the total weight of the composition and sufficient to increase the cloud point of the surface modifier above the sterilization temperature of the nanoparticles, wherein said nanoparticles are resistant to particle size growth when said composition is heat sterilized at 121° C. for 15 minutes.
Claim 7
Dependent Claim
12 words
The composition of claim 1 wherein said nonionic surfactant is a poloxamine.
Claim 8
Dependent Claim
26 words
The composition of claim 2 wherein said surface modifier is a poloxamine, said cloud point modifier is polyethylene glycol, and said diagnostic agent is ethyl 3,5-diacetoamido-2,4,6-triiodobenzoate
Claim 9
Dependent Claim
25 words
The composition of claim 1 wherein said cloud point modifier is selected from the group consisting of polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin and glycerol.
Claim 10
Dependent Claim
26 words
The composition of claim 1 in wherein said cloud point modifier increases the cloud point of said surface modifier above the sterilization temperature of the nanoparticles.
Claim 11
Dependent Claim
35 words
A method of making the composition of claim 1 comprised of contacting said nanoparticles with said cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.
Claim 12
Dependent Claim
13 words
The method of claim 9 further comprising the step of sterilizing said nanoparticle.
Claim 13
Dependent Claim
13 words
The method of claim 10 wherein said sterilizing is by steam heat autoclaving.
Claim 14
Dependent Claim
12 words
The composition of claim 1 wherein said nanoparticles contain a therapeutic agent.
Claim 15
Dependent Claim
18 words
The composition of claim 1 wherein said nanoparticles have a mean particle size of less than 400 nm.
Claim 16
Dependent Claim
25 words
The composition of claim 1 wherein said nonionic surfactant is selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene stearates, tyloxapol, poloxamers and poloxamines.
References Cited (Backward Citations)
EP0498482A2
Cited
US5145684A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-09-12 | 1998-03-14 | 1998-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-12 | 2002-03-14 | 2002-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-12 | 2006-03-14 | 2006-09-13 | $7700.00 | Window Closed / Lapsed |