US5336699A
Expired / Lapsed
US
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Bone cement having chemically joined reinforcing fillers
Assignee: Orthopaedic Research Institute
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Filing: 1992-12-28
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Granted: 1994-08-09
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Expires: 2012-12-28
Abstract
Abstract Improved polymeric orthopaedic compositions are disclosed wherein sized, functional fibers are incorporated into a physiologically acceptable matrix. The compositions of the invention can be fabricated in the form of particulate powders adapted for reinforcment of bone cements, continuous media for such cements, and orthopaedic implant coatings. A complete implant attachment system is also provided, made up of a fiber reinforced implant coating, and a compatible fiber-reinforced cement. In preferred forms, the fibers have a layer of sizing thereover which is chemically joined both to the surface of the fibers and to the surrounding matrix, and the fibers are present at a level of at least about 6 volume percent. If desired, sized radiopaque particles may be incorporated into the compositions of the invention. The fibers are advantageously polymeric in nature and of intermediate stiffness, whereas the matrix fraction is preferably polymethylmethacrylate.
Inventors
- 👤 Francis W. Cooke
- 👤 Thomas R. Marrero
- 👤 Hirotsuga K. Yasuda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:15
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/88; A61B17/8802; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61F2/3094; A61F2/30965; A61L; A61L24/00; A61L24/0047; A61L24/0073; A61L24/0094; A61L24/04; A61L24/06; A61B90/00; A61B90/39; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/3008; A61F2/46; A61F2002/4631; A61F2250/00; A61F2250/0058; A61F2250/0096; A61F2250/0098; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 87
Claim 1
Independent Claim
131 words
An orthopaedic composition, comprising: an amount of a physiologically acceptable polymeric matrix material; and a quantity of fibers disbursed in said matrix for enhancing functional qualities of the composition, said fibers having a layer of a sizing material thereover which is chemically joined to the surface of the fibers, said sizing material on the fibers also being chemically joined with the matrix material, said fibers being present in said composition in an effective amount for reinforcing said matrix and having an average length of from about 1 μm to about 2 cm, said fibers having a stiffness defined as the product of the tensile elastic modulus of the fibers and the area moment of inertia of the fibers, said stiffness being from about 1.0×10 -13 to 150×10 -13 Nm 2 .
Claim 2
Dependent Claim
131 words
An orthopaedic composition, comprising: an amount of a physiologically acceptable polymeric matrix material; and a quantity of fibers disbursed in said matrix for enhancing functional qualities of the composition, said fibers having a layer of a sizing material thereover which is chemically joined to the surface of the fibers, said sizing material on the fibers also being chemically joined with the matrix material, said fibers being present in said composition in an effective amount for reinforcing said matrix and having an average length of from about 1 μm to about 2 cm, said fibers having a stiffness defined as the product of the tensile elastic modulus of the fibers and the area moment of inertia of the fibers, said stiffness being from about 1.0×10 -13 to 150×10 -13 Nm 2 .
Claim 3
Dependent Claim
20 words
An orthopaedic composition as set forth in claim 1, wherein said sizing material is directly chemically joined to said fibers.
Claim 4
Dependent Claim
21 words
An orthopaedic composition as set forth in claim 1, wherein said sizing material is a coupling agent different from said matrix.
Claim 5
Dependent Claim
26 words
An orthopaedic composition as set forth in claim 1, wherein said fibers comprise polymeric reinforcing fibers formed of a relatively high strength polymer of intermediate stiffness.
Claim 6
Dependent Claim
31 words
An orthopaedic composition as set forth in claim 1, said composition being in the form of a particulate powder adapted for placement in a continuous medium to form a bone cement.
Claim 7
Dependent Claim
25 words
An orthopaedic composition as set forth in claim 5, the particles of said powder having an average size of from about 5 to 100 μm.
Claim 8
Dependent Claim
18 words
An orthopaedic composition as set forth in claim 5, said fibers being in the form of polymeric fibers.
Claim 9
Dependent Claim
23 words
An orthopaedic composition as set forth in claim 7, said fibers being selected from the group consisting of polyaramids, polyesters, polyalkenes and polyamides.
Claim 10
Dependent Claim
22 words
An orthopaedic composition as set forth in claim 7, said fibers having a diameter of from about 1 μm to 100 μm.
Claim 11
Dependent Claim
24 words
An orthopaedic composition as set forth in claim 9, wherein at least certain of said fibers have a diameter of from about 2-15 μm.
Claim 12
Dependent Claim
23 words
An orthopaedic composition as set forth in claim 7, said fibers having a length of up to about the diameter of said particle.
Claim 13
Dependent Claim
23 words
An orthopaedic composition as set forth in claim 12, wherein said stiffness is from about 10×10 -13 to 75×10 -13 Nm 2 .
Claim 14
Dependent Claim
28 words
An orthopaedic composition as set forth in claim 7, wherein said fibers have a room temperature fatigue strength of at least about 7 MPa at 10 6 cycles.
Claim 15
Dependent Claim
21 words
An orthopaedic composition as set forth in claim 13, said fatigue strength being at least 30 MPa at 10 6 cycles.
Claim 16
Dependent Claim
27 words
An orthopaedic composition as set forth in claim 7, said fibers being present in said powder at a level of from about 6 to 70 volume percent.
Claim 17
Dependent Claim
16 words
An orthopaedic composition as set forth in claim 15, said level being about 50 volume percent.
Claim 18
Dependent Claim
18 words
An orthopaedic composition as set forth in claim 5, wherein said matrix is a substituted or unsubstituted acrylate.
Claim 19
Dependent Claim
13 words
An orthopaedic composition as set forth in claim 17, said matrix being polymethylmethacrylate.
Claim 20
Dependent Claim
25 words
An orthopaedic composition as set forth in claim 18, said polymethylmethacrylate having a viscosity average molecular weight of not less than about 1×10 5 g./mole.
Claim 21
Dependent Claim
28 words
An orthopaedic composition as set forth in claim 5, wherein said sizing material is selected from the group consisting of ethyl silane, methylmethacrylate, ethylmethacrylate, ethylene, propylene and methane.
Claim 22
Dependent Claim
16 words
An orthopaedic composition as set forth in claim 20, wherein said sizing material is an acrylate.
Claim 23
Dependent Claim
15 words
An orthopaedic composition as set forth in claim 20, wherein said sizing material is methylmethacrylate.
Claim 24
Dependent Claim
20 words
An orthopaedic composition as set forth in claim 5, including a radiopaque agent, said agent having said sizing material thereover.
Claim 25
Dependent Claim
42 words
An orthopaedic composition as set forth in claim 5, wherein said sizing material has been chemically joined to the fibers by a technique selected from the group consisting of glow discharge induced reaction, ultraviolet induced reaction, free-radical induced reaction and catalytic reaction.
Claim 26
Dependent Claim
45 words
An orthopaedic composition as set forth in claim 24, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out at a frequency of up to about 100 MHz at a power level of at least about 20 W.
Claim 27
Dependent Claim
33 words
An orthopaedic composition as set forth in claim 25, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out at a frequency between about 5-15 MHz
Claim 28
Dependent Claim
57 words
An orthopaedic composition as set forth in claim 24, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out for a time period equivalent to 30 minutes exposure for each 0.05 kg of fibers having a density of about 1 g/cm 3 and an average diameter of about 10 μm.
Claim 29
Dependent Claim
30 words
An orthopaedic composition as set forth in claim 1, said composition being in the form of a continuous medium adapted for mixing with reinforced particles to form a bone cement.
Claim 30
Dependent Claim
18 words
An orthopaedic composition as set forth in claim 28, said fibers being in the form of polymeric fibers.
Claim 31
Dependent Claim
23 words
An orthopaedic composition as set forth in claim 29, said fibers being selected from the group consisting of polyaramids, polyesters, polyalkenes and polyamides.
Claim 32
Dependent Claim
22 words
An orthopaedic composition as set forth in claim 29, said fibers having a diameter of from about 1 μm to 100 μm.
Claim 33
Dependent Claim
24 words
An orthopaedic composition as set forth in claim 31, wherein at least certain of said fibers have a diameter of from about 2-15 μm.
Claim 34
Dependent Claim
20 words
An orthopaedic composition as set forth in claim 28, said fibers having a length of up to about 5 min.
Claim 35
Dependent Claim
23 words
An orthopaedic composition as set forth in claim 29, wherein said stiffness is from about 10×10 -3 to 75×10 -13 Nm 2 .
Claim 36
Dependent Claim
28 words
An orthopaedic composition as set forth in claim 28, wherein said fibers have a room temperature fatigue strength of at least about 7 MPa at 10 6 cycles.
Claim 37
Dependent Claim
21 words
An orthopaedic composition as set forth in claim 35, said fatigue strength being at least 30 MPa at 10 6 cycles.
Claim 38
Dependent Claim
25 words
An orthopaedic composition as set forth in claim 28, said fibers being present in said medium at a level of from about 6-20 volume percent.
Claim 39
Dependent Claim
18 words
An orthopaedic composition as set forth in claim 38, wherein said matrix is a substituted or unsubstituted acrylate.
Claim 40
Dependent Claim
13 words
An orthopaedic composition as set forth in claim 38, said matrix being polymethylmethacrylate.
Claim 41
Dependent Claim
25 words
An orthopaedic composition as set forth in claim 39, said polymethylmethacrylate having a viscosity average molecular weight of not less than about 1×10 5 g./mole.
Claim 42
Dependent Claim
28 words
An orthopaedic composition as set forth in claim 28, wherein said sizing material is selected from the group consisting of ethyl silane, methylmethacrylate, ethylmethacrylate, ethylene, propylene and methane.
Claim 43
Dependent Claim
16 words
An orthopaedic composition as set forth in claim 41, wherein said sizing material is an acrylate.
Claim 44
Dependent Claim
15 words
An orthopaedic composition as set forth in claim 41, wherein said sizing material is polymethylmethacrylate.
Claim 45
Dependent Claim
19 words
An orthopaedic composition as set forth claim 28, including a radiopaque agent, said agent having said sizing material thereover.
Claim 46
Dependent Claim
42 words
An orthopaedic composition as set forth in claim 28, wherein said sizing material has been chemically joined to the fibers by a technique selected from the group consisting of glow discharge induced reaction, ultraviolet induced reaction, free-radical induced reaction and catalytic reaction.
Claim 47
Dependent Claim
45 words
An orthopaedic composition as set forth in claim 45, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out at a frequency of up to about 100 MHz at a power level of at least about 20 W.
Claim 48
Dependent Claim
33 words
An orthopaedic composition as set forth in claim 46, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out at a frequency between about 5-15 MHz.
Claim 49
Dependent Claim
57 words
An orthopaedic composition as set forth in claim 45, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out for a time period equivalent to 30 minutes exposure for each 0.05 kg of fibers having a density of about 1 g/cm 3 and an average diameter of about 10 μm.
Claim 50
Dependent Claim
24 words
An orthopaedic composition as set forth in claim 1, said composition being in the form of a coating for application to an orthopaedic appliance.
Claim 51
Dependent Claim
18 words
An orthopaedic composition as set forth in claim 49, said fibers being in the form of polymeric fibers.
Claim 52
Dependent Claim
23 words
An orthopaedic composition as set forth in claim 50, said fibers being selected from the group consisting of polyaramids, polyesters, polyalkenes and polyamides.
Claim 53
Dependent Claim
20 words
An orthopaedic composition as set forth in claim 50, said fibers having a diameter of from about 1μm to 100μm.
Claim 54
Dependent Claim
24 words
An orthopaedic composition as set forth in claim 52, wherein at least certain of said fibers have a diameter of from about 2-15 μm.
Claim 55
Dependent Claim
23 words
An orthopaedic composition as set forth in claim 49, wherein said stiffness is from about 10×10 -13 to 75×10 -13 Nm 2 .
Claim 56
Dependent Claim
28 words
An orthopaedic composition as set forth in claim 49, wherein said fibers have a room temperature fatigue strength of at least about 7 MPa at 10 6 cycles.
Claim 57
Dependent Claim
21 words
An orthopaedic composition as set forth in claim 55, said fatigue strength being at least 30 MPa at 10 6 cycles.
Claim 58
Dependent Claim
24 words
An orthopaedic composition as set forth in claim 49, said fibers being present at a level of from about 6 to 70 volume percent.
Claim 59
Dependent Claim
16 words
An orthopaedic composition as set forth in claim 57, said level being about 50 volume percent.
Claim 60
Dependent Claim
18 words
An orthopaedic composition as set forth in claim 49, wherein said matrix is a substituted or unsubstituted acrylate.
Claim 61
Dependent Claim
13 words
An orthopaedic composition as set forth in claim 59, said matrix being polymethylmethacrylate.
Claim 62
Dependent Claim
25 words
An orthopaedic composition as set forth in claim 60, said polymethylmethacrylate having a viscosity average molecular weight of not less than about 1×10 5 g./mole.
Claim 63
Dependent Claim
28 words
An orthopaedic composition as set forth in claim 49, wherein said sizing material is selected from the group consisting of ethyl silane, methylmethacrylate, ethylmethacrylate, ethylene, propylene and methane.
Claim 64
Dependent Claim
16 words
An orthopaedic composition as set forth in claim 62, wherein said sizing material is an acrylate.
Claim 65
Dependent Claim
15 words
An orthopaedic composition as set forth in claim 63, wherein said sizing material is polymethylmethacrylate.
Claim 66
Dependent Claim
20 words
An orthopaedic composition as set forth in claim 49, including a radiopaque agent, said agent having said sizing material thereover.
Claim 67
Dependent Claim
42 words
An orthopaedic composition as set forth in claim 49, wherein said sizing material has been chemically joined to the fibers by a technique selected from the group consisting of glow discharge induced reaction, ultraviolet induced reaction, free-radical induced reaction and catalytic reaction.
Claim 68
Dependent Claim
45 words
An orthopaedic composition as set forth in claim 66, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out at a frequency of up to about 100 MHz at a power level of at least about 20 W.
Claim 69
Dependent Claim
33 words
An orthopaedic composition as set forth in claim 67, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out at a frequency between about 5-15 MHz.
Claim 70
Dependent Claim
57 words
An orthopaedic composition as set forth in claim 67, wherein glow discharge reaction of the sizing material while in contact with said fibers is carried out for a time period equivalent to 30 minutes exposure for each 0.05 kg of fibers having a density of about 1 g/cm 3 and an average diameter of about 10 μm.
Claim 71
Dependent Claim
60 words
A bone cement comprising: a continuous medium comprising a physiologically acceptable polymeric material; and a particulate powder dispersed in said continuous medium, the particles making up said powder including a physiologically acceptable polymeric matrix and reinforcing fibers extending through and at least partially out of the particles, said polymeric material of the continuous medium being chemically joined with said fibers.
Claim 72
Dependent Claim
60 words
A bone cement comprising: a continuous medium comprising a physiologically acceptable polymeric material; and a particulate powder dispersed in said continuous medium, the particles making up said powder including a physiologically acceptable polymeric matrix and reinforcing fibers extending through and at least partially out of the particles, said polymeric material of the continuous medium being chemically joined with said fibers.
Claim 73
Dependent Claim
18 words
The bone cement of claim 70, said powder comprising from about 55-80% by weight of the bone cement.
Claim 74
Dependent Claim
15 words
The bone cement of claim 70, said continuous medium comprising a substituted or unsubstituted acrylate.
Claim 75
Dependent Claim
11 words
The bone cement of claim 72, said continuous medium comprising polymethylmethacrylate.
Claim 76
Dependent Claim
20 words
The bone cement of claim 70, said continuous medium including therein fibers distinct from the fibers present in said particles.
Claim 77
Dependent Claim
17 words
The bone cement of claim 70, said continuous medium including therein an amount of sized radiopaque agent.
Claim 78
Dependent Claim
20 words
The bone cement of claim 70, said fibers being selected from the group consisting of polyaramids, polyesters, polyalkenes and polyamides.
Claim 79
Dependent Claim
35 words
The bone cement of claim 77, said fibers having a layer of sizing material thereover chemically joined to the surface thereof, said sizing material on the fibers also being chemically joined with said matrix material.
Claim 80
Dependent Claim
20 words
The bone cement of claim 77, said continuous medium also being chemically joined to the sizing material on said fibers.
Claim 81
Independent Claim
61 words
A method of preparing an orthopaedic composition comprising the steps of: chemically bonding a layer of a sizing material onto the outer surfaces of a quantity of fibers; and polymerizing a monomeric material in the presence of said sized fibers for chemically joining the sized fibers to the resultant polymerized material in order to enhance the properties of the orthopaedic composition.
Claim 82
Independent Claim
61 words
A method of preparing an orthopaedic composition comprising the steps of: chemically bonding a layer of a sizing material onto the outer surfaces of a quantity of fibers; and polymerizing a monomeric material in the presence of said sized fibers for chemically joining the sized fibers to the resultant polymerized material in order to enhance the properties of the orthopaedic composition.
Claim 83
Dependent Claim
48 words
A method of preparing an orthopaedic composition as set forth in claim 79, wherein said step of chemically bonding a sizing material to the fibers comprises using a technique selected from the group consisting of glow discharge induced reaction, ultraviolet induced reaction, free-radical induced reaction, and catalytic reaction.
Claim 84
Dependent Claim
74 words
A method of preparing an orthopaedic composition as set forth in claim 80, wherein glow discharge polymerization is employed to couple a sizing layer onto the surface of the fibers, said glow discharge polymerization being effected by exposing the surfaces of the fibers and the sizing material to an electromagnetic field at a frequency of 1 to 100 MHz at a power of at least 20 W per square centimeter of fiber surface area.
Claim 85
Dependent Claim
39 words
A method of preparing an orthopaedic composition as set forth in claim 81, wherein said composition is in the form of a bulk solid, and further including the steps of comminuting said bulk solid to form a particulate powder.
Claim 86
Dependent Claim
146 words
An orthopaedic composition, consisting essentially of: an amount of a physiologically acceptable polymeric matrix material, said material selected from the group consisting of substituted acrylates and unsubstituted acrylates; and a quantity of fibers disbursed in said matrix for enhancing functional qualities of the composition, said fibers having a layer of a sizing material thereover which is chemically joined to the surface of the fibers, said sizing material of the fibers also being chemically joined with the matrix material, said fibers being present in said composition in an effective amount for reinforcing said matrix and having an average length of from about 1 μm to about 2 cm, said fibers having a stiffness defined as the product of the tensile elastic modulus of the fibers and the area moment of inertia of the fibers, said stiffness being from about 1.0×10 -13 to 150×10 -13 Nm 2 .
Claim 87
Dependent Claim
146 words
An orthopaedic composition, consisting essentially of: an amount of a physiologically acceptable polymeric matrix material, said material selected from the group consisting of substituted acrylates and unsubstituted acrylates; and a quantity of fibers disbursed in said matrix for enhancing functional qualities of the composition, said fibers having a layer of a sizing material thereover which is chemically joined to the surface of the fibers, said sizing material of the fibers also being chemically joined with the matrix material, said fibers being present in said composition in an effective amount for reinforcing said matrix and having an average length of from about 1 μm to about 2 cm, said fibers having a stiffness defined as the product of the tensile elastic modulus of the fibers and the area moment of inertia of the fibers, said stiffness being from about 1.0×10 -13 to 150×10 -13 Nm 2 .
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