US5324739A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compound exhibiting antiproliferative activity against cells
Assignee: Oregon State University
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Filing: 1993-10-07
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Granted: 1994-06-28
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Expires: 2013-10-07
Abstract
Abstract Isomers of a cytotoxic compound isolated and purified from a marine cyanobacterium Lyngbya majuscula are disclosed. The isomers termed Curacin A and Curacin B exhibits substantial biological activity against proliferating cells. The Curacin A and Curacin B isomers appear to be antimitotics. Methods for using the isomers are also disclosed.
Inventors
- 👤 William H. Gerwick
- 👤 Philip J. Proteau
- 👤 Dale G. Nagle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 10:44
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/08; C07D277/10
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
6 words
A compound of the formula: ##STR3##
Claim 2
Dependent Claim
6 words
A compound of the formula: ##STR3##
Claim 3
Dependent Claim
5 words
Curacin A and stereoisomers thereof.
Claim 4
Dependent Claim
5 words
Curacin A and stereoisomers thereof.
Claim 5
Dependent Claim
43 words
A composition of matter comprising a pharmaceutically inert carrier and a compound selected from a group consisting of Curacin A and stereoisomers thereof, the compound being present in the composition in an amount sufficient to act as an antiproliferative agent to living cells.
Claim 6
Dependent Claim
43 words
A composition of matter comprising a pharmaceutically inert carrier and a compound selected from a group consisting of Curacin A and stereoisomers thereof, the compound being present in the composition in an amount sufficient to act as an antiproliferative agent to living cells.
Claim 7
Independent Claim
44 words
A method of treating an animal subject to inhibit the proliferation of living cells in the subject, the method comprising administering to the subject an effective amount of a formulation comprising a compound selected from a group consisting of Curacin A and stereoisomers thereof.
Claim 8
Independent Claim
44 words
A method of treating an animal subject to inhibit the proliferation of living cells in the subject, the method comprising administering to the subject an effective amount of a formulation comprising a compound selected from a group consisting of Curacin A and stereoisomers thereof.
Claim 9
Independent Claim
53 words
A method for inhibiting proliferation of living cells comprising contacting the cells with an amount of a formulation comprising a compound selected from a group consisting of Curacin A and stereoisomers thereof, the amount being sufficient to inhibit proliferation of the cells compared to otherwise identical control cells not contacted with the formulation.
Claim 10
Independent Claim
53 words
A method for inhibiting proliferation of living cells comprising contacting the cells with an amount of a formulation comprising a compound selected from a group consisting of Curacin A and stereoisomers thereof, the amount being sufficient to inhibit proliferation of the cells compared to otherwise identical control cells not contacted with the formulation.
Claim 11
Independent Claim
51 words
A method for reducing a population of arthropods, comprising contacting the population with a formulation comprising an amount of a compound selected from a group consisting of Curacin A and stereoisomers thereof, the amount being sufficient to reduce the population compared to an otherwise control population not contacted with the formulation.
Claim 12
Independent Claim
51 words
A method for reducing a population of arthropods, comprising contacting the population with a formulation comprising an amount of a compound selected from a group consisting of Curacin A and stereoisomers thereof, the amount being sufficient to reduce the population compared to an otherwise control population not contacted with the formulation.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-06-27 | 1997-12-27 | 1998-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-27 | 2001-12-27 | 2002-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-27 | 2005-12-27 | 2006-06-28 | $7700.00 | Window Closed / Lapsed |