US5324324A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coated implantable stimulation electrode and lead
Assignee: Siemens AG
•
Filing: 1992-10-13
•
Granted: 1994-06-28
•
Expires: 2012-10-13
Abstract
Abstract An implantable stimulation lead having an anti-inflammatory coating on the exposed surface area of the distal tip electrode. The coating is a semi-viscous or gelatinous material having the ability to absorb physiological fluids to provide electrical conductivity through the coating. The coating preferably has a matrix having an innate hypo-inflammatory property which can be combined with drugs and therapeutic agents to deliver the drugs and agents by co-dissolution or diffusion, or alternatively the matrix material can be used as a coating to keep the electrode surface electrochemically clean prior to and during implant.
Inventors
- 👤 David J. Vachon
- 👤 John R. Helland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:00
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05; A61N1/056
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
117 words
An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising: an electrical conductor having a proximal end and a distal end; an insulation sheath covering said conductor; an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a composition including a therapeutic agent and a biocompatible, matrix material comprising crosslinked proteins, wherein said proteins are selected from the group consisting of albumin, collagen and gelatin.
Claim 2
Dependent Claim
117 words
An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising: an electrical conductor having a proximal end and a distal end; an insulation sheath covering said conductor; an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a composition including a therapeutic agent and a biocompatible, matrix material comprising crosslinked proteins, wherein said proteins are selected from the group consisting of albumin, collagen and gelatin.
Claim 3
Dependent Claim
18 words
The implantable stimulation lead of claim 1, wherein said crosslinked proteins comprise proteins crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) -carbodiimide hydrochloride.
Claim 4
Dependent Claim
113 words
An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising: an electrical conductor having a proximal end and a distal end; an insulation sheath covering said conductor; an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a composition including a therapeutic agent and a biocompatible, matrix material comprising a soluble starch selected from the group consisting of amylodextrin and amylogen.
Claim 5
Dependent Claim
113 words
An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising: an electrical conductor having a proximal end and a distal end; an insulation sheath covering said conductor; an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a composition including a therapeutic agent and a biocompatible, matrix material comprising a soluble starch selected from the group consisting of amylodextrin and amylogen.
Claim 6
Dependent Claim
122 words
An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising: an electrical conductor having a proximal end and a distal end; an insulation sheath covering said conductor; an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a biocompatible, matrix material comprising hydrophilic polymer derivatives selected from the group consisting of polyethylene glycols, polyvinylpyrrolidones, polyacrylamide, and polyvinylalcohol, wherein said hydrophilic polymer derivatives are modified to incorporate a photo-activated crosslinking moiety.
Claim 7
Dependent Claim
122 words
An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising: an electrical conductor having a proximal end and a distal end; an insulation sheath covering said conductor; an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a biocompatible, matrix material comprising hydrophilic polymer derivatives selected from the group consisting of polyethylene glycols, polyvinylpyrrolidones, polyacrylamide, and polyvinylalcohol, wherein said hydrophilic polymer derivatives are modified to incorporate a photo-activated crosslinking moiety.
Claim 8
Dependent Claim
122 words
An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising: an electrical conductor having a proximal end and a distal end; an insulation sheath covering said conductor; an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a biocompatible, matrix material comprising hydrophilic polymer derivatives selected from the group consisting of polyethylene glycols, polyvinylpyrrolidones, polyacrylamide, and polyvinylalcohol, wherein said hydrophilic polymer derivatives are modified to incorporate a thermally-activated crosslinking moiety.
Claim 9
Dependent Claim
122 words
An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising: an electrical conductor having a proximal end and a distal end; an insulation sheath covering said conductor; an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a biocompatible, matrix material comprising hydrophilic polymer derivatives selected from the group consisting of polyethylene glycols, polyvinylpyrrolidones, polyacrylamide, and polyvinylalcohol, wherein said hydrophilic polymer derivatives are modified to incorporate a thermally-activated crosslinking moiety.
References Cited (Backward Citations)
US4033357A
Cited
US4281668A
Cited
US4711251A
Cited
US4711251B1
Cited
US4506680A
Cited
US4606118A
Cited
US4844099A
Cited
US4827940A
Cited
US5103837A
Cited
US4953564A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-06-27 | 1997-12-27 | 1998-06-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-27 | 2001-12-27 | 2002-06-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-27 | 2005-12-27 | 2006-06-28 | $7700.00 | Window Closed / Lapsed |