US5312620A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymeric immunological adjuvants
Assignee: Individual
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Filing: 1991-10-30
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Granted: 1994-05-17
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Expires: 2011-10-30
Abstract
Abstract Adjuvants for enhancing the immune response to an antigen are provided comprising the adjuvant incorporated into a lipid layer where the adjuvant is covalently or non-covalently involved in a polymeric system. Conveniently, the adjuvant may be conjugated to a polymerizable group and co-polymerized with a water-soluble and/or amphiphilic polymerizable monomer or combined with a polymerized amphiphile. The adjuvant and antigen may then be administered to a mammalian host to obtain enhanced immune response.
Inventors
- 👤 Hans O. Ribi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; A61K9/1273; A61K39/00; A61K39/39; A61K2039/555; A61K2039/55511; A61K2039/55555; A61K2039/55572
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
99 words
A polymeric immunological adjuvant composition comprising: a copolymer comprising at least one adjuvant joined to a water soluble addition polymerizable acrylyl or methacrylyl monomer through a linking group and a lamellar forming lipid comprising a chain of from 8 to not more than 36 carbon atoms and joined to a water soluble addition polymerizable acrylyl or methacrylyl monomer; said lipid adjuvant selected from the group consisting of monophosphoryl lipid A, lipopolysaccharide, BCG cell wall skeleton, diphosphoryl lipid A, muramyl di- or tripeptide, muramyl dipeptide-phosphatidyl-ethanolamine, muramyltripeptide phosphatidylethanolamine, trehalose monomycolate, trehalose dimycolate, lipid X, isoprinosine, and lithosperman (A, B or C).
Claim 2
Dependent Claim
99 words
A polymeric immunological adjuvant composition comprising: a copolymer comprising at least one adjuvant joined to a water soluble addition polymerizable acrylyl or methacrylyl monomer through a linking group and a lamellar forming lipid comprising a chain of from 8 to not more than 36 carbon atoms and joined to a water soluble addition polymerizable acrylyl or methacrylyl monomer; said lipid adjuvant selected from the group consisting of monophosphoryl lipid A, lipopolysaccharide, BCG cell wall skeleton, diphosphoryl lipid A, muramyl di- or tripeptide, muramyl dipeptide-phosphatidyl-ethanolamine, muramyltripeptide phosphatidylethanolamine, trehalose monomycolate, trehalose dimycolate, lipid X, isoprinosine, and lithosperman (A, B or C).
Claim 3
Dependent Claim
21 words
A polymeric immunological adjuvant composition according to claim 1 comprising a water soluble addition polymerizable monomer free of a lipid group.
Claim 4
Dependent Claim
23 words
A combination composition comprising a polymeric immunological adjuvant composition according to claim 1 in combination with monomeric or polymeric lamellar forming lipid molecules.
Claim 5
Dependent Claim
33 words
A combination adjuvant composition comprising: monomeric lamellar forming adjuvant, wherein said adjuvant is lamellar forming or is joined to a lamellar forming lipid, and a polymeric immunological adjuvant composition according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-05-16 | 1997-11-15 | 1998-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-05-16 | 2001-11-15 | 2002-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-05-16 | 2005-11-15 | 2006-05-17 | $7700.00 | Window Closed / Lapsed |