Compositions of iodoaniline derivatives for visualization of the gastrointestinal tract

Claim 1

An orally or rectally administerable x-ray contrast composition in a dispersion form for visualization of the gastrointestinal tract comprising a contrast agent having the formula, or a pharmaceutically acceptable salt thereof: ##STR6## wherein Z=H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R 1 and R 2 are independently H, C 1 -C 25 alkyl, cycloalkyl, acetyl or halo-lower-alkyl, wherein said C 1 -C 25 alkyl, cycloalkyl, and halo-lower-alkyl are optionally substituted with, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy and said acetyl is optionally substituted with fluoro-lower-alkyl, aryl, lower alkoxy, hydroxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy; n is 1-4; y is 1-4; and x is 1 or 2; and a physiologically acceptable carrier comprising a surfactant selected from the group consisting of cationic, anionic, nonionic, and zwitterionic surfactants.

Claim 15

A method of carrying out x-ray examination of the gastrointestinal tract of a patient in need of such examination which comprises orally or rectally administering to the patient an x-ray contrast composition in a dispersion form comprising: an x-ray contrast agent, or a pharmaceutically acceptable salt thereof, having the formula: ##STR7## wherein Z=H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R 1 and R 2 are independently H, C 1 -C 25 alkyl, cycloalkyl, acetyl or halo-lower-alkyl, wherein said C 1 -C 25 5 alkyl, cycloalkyl, and halo-lower-alkyl are optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy and said acetyl is optionally substituted with fluoro-lower-alkyl, aryl, lower alkoxy, hydroxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy n is 1-4; y is 1-4; and x is 1 or 2; and a physiologically acceptable carrier comprising a surfactant selected from the group consisting of cationic, anionic, nomonic, and zwitterionic surfactants.

Claim 16

A method of carrying out x-ray examination of the gastrointestinal tract of a patient in need of such examination which comprises orally or rectally administering to the patient an x-ray contrast composition in a dispersion form comprising: an x-ray contrast agent, or a pharmaceutically acceptable salt thereof, having the formula: ##STR7## wherein Z=H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R 1 and R 2 are independently H, C 1 -C 25 alkyl, cycloalkyl, acetyl or halo-lower-alkyl, wherein said C 1 -C 25 5 alkyl, cycloalkyl, and halo-lower-alkyl are optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy and said acetyl is optionally substituted with fluoro-lower-alkyl, aryl, lower alkoxy, hydroxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy n is 1-4; y is 1-4; and x is 1 or 2; and a physiologically acceptable carrier comprising a surfactant selected from the group consisting of cationic, anionic, nomonic, and zwitterionic surfactants.