US5306305A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of coating implants with bony structure
Assignee: Etex Corp
•
Filing: 1992-01-31
•
Granted: 1994-04-26
•
Expires: 2012-01-31
Abstract
Abstract Implants associated with bone are coated with natural bony tissue by incubating the implant with osteoblasts under conditions where the osteoblasts grow and lay down a bony coating. Different methods are provided for maintaining the osteoblasts in contact with the implant and allowing for the growth and maintenance of the osteoblasts with formation of the bony tissue. The resulting coated implants can provide for a better juncture with the natural tissue in the patient, so as to provide for a more comfortable and effective prosthesis or other device.
Inventors
- 👤 Dosuk Lee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 22:56
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61L; A61L27/00; A61L27/36; A61L27/38; A61F2/3094; A61F2/32; A61F2/36; A61F2/3662; A61F2/367; A61F2/3676; A61F2/3609; A61F2002/3625; A61F2002/3631; A61F2002/3678; A61F2002/368; A61F2310/00; A61F2310/00005; A61F2310/00011; A61F2310/00017; A61F2310/00023; A61F2310/00029; A61F2310/00389; A61F2310/00958
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
89 words
An in vitro method for producing an implant device comprising a porous metal or metal alloy surface of said implant device coated with bony tissue as a result of laying down of said bony tissue by osteoblasts, said method comprising: dispersing viable osteoblast cells in a gel medium comprising a nutrient medium; coating said surface with said gel medium; and incubating said gel medium coated surface in a growth medium providing nutrients for the growth of said osteoblasts for sufficient time for said bony tissue to be laid down.
Claim 2
Dependent Claim
89 words
An in vitro method for producing an implant device comprising a porous metal or metal alloy surface of said implant device coated with bony tissue as a result of laying down of said bony tissue by osteoblasts, said method comprising: dispersing viable osteoblast cells in a gel medium comprising a nutrient medium; coating said surface with said gel medium; and incubating said gel medium coated surface in a growth medium providing nutrients for the growth of said osteoblasts for sufficient time for said bony tissue to be laid down.
Claim 3
Dependent Claim
43 words
A method according to claim 1, wherein said osteoblasts are present in said gel medium in a sufficient number and concentration to coat said surface with a stable bony coating, said concentration is about 10 5 to 10 6 cells/75 cm 2 .
Claim 4
Dependent Claim
12 words
A method according to claim 1, wherein said growth medium comprises serum.
Claim 5
Dependent Claim
38 words
A method according to claim 1, wherein said incubation comprises about 21 days in a first growth medium comprising serum and then an additional at least about 7 days wherein said medium comprises β-glycerol media and ascorbic acid.
Claim 6
Dependent Claim
20 words
A method according to claim 1, wherein said gel medium is at a thickness of about 0.05 to 1 mm.
Claim 7
Dependent Claim
115 words
A in vitro method for producing an implant device comprising a porous metal or metal alloy surface of said implant device coated with bony tissue as a result of laying down of said bony tissue by osteoblasts, said method comprising: dispersing viable osteoblast containing tissue from a mammalian host in a physiological acceptable buffer solution; transferring the osteoblasts into a gel medium comprising a nutrient medium; coating said surface with said gel medium; and incubating said gel medium coated surface in a growth medium providing nutrients for the growth of said osteoblasts for sufficient time for said body tissue to be laid down, to provide a coated device to be introduced into said mammalian host.
Claim 8
Dependent Claim
115 words
A in vitro method for producing an implant device comprising a porous metal or metal alloy surface of said implant device coated with bony tissue as a result of laying down of said bony tissue by osteoblasts, said method comprising: dispersing viable osteoblast containing tissue from a mammalian host in a physiological acceptable buffer solution; transferring the osteoblasts into a gel medium comprising a nutrient medium; coating said surface with said gel medium; and incubating said gel medium coated surface in a growth medium providing nutrients for the growth of said osteoblasts for sufficient time for said body tissue to be laid down, to provide a coated device to be introduced into said mammalian host.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-04-25 | 1997-10-25 | 1998-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-04-25 | 2001-10-25 | 2002-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-04-25 | 2005-10-25 | 2006-04-26 | $7700.00 | Window Closed / Lapsed |