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US5306242A Expired / Lapsed US ⏱️ 0.0 years remaining

Recirculation through plural pump cassettes for a solution compounding apparatus

Assignee: Hospira Inc
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Filing: 1992-12-15
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Granted: 1994-04-26
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Expires: 2012-12-15
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Abstract

Abstract An apparatus and method are disclosed for compounding of parenteral admixture solutions, and recirculation with the admixture solution being formed. The apparatus includes a multiple pump cassette configured for operative association with a pump driver, whereby one or more selected source solutions are delivered through a pump cassette to an associated admixture container. After pumping of each source solution, the present method contemplates that the admixture being formed is recirculated through the pump cassettes thereby diluting any source solution in the cassettes and associated tubing. In this manner, the possible mixture of incompatible source solutions, resulting in formation of precipitate, is desirably avoided.

Inventors

  • 👤 Thomas P. Joyce
  • 👤 John S. Ziegler

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-06 03:11
CPC Classifications
A; A61; A61J; A61J3/00; A61J3/002; Y; Y10; Y10T; Y10T137/00; Y10T137/8593; Y10T137/85954; Y10T137/85978; Y10T137/86107; Y10T137/86131; Y10T137/86139

Claims Analysis

Total Claims: 16
Claim 1
Independent Claim 181 words
An apparatus for compounding an admixture solution from at least one source solution, comprising: first and second pump cassettes, each cassette having a fluid flow path including a plurality of liquid inlets and liquid outlets, the liquid flow path joining said inlets and said outlets in fluid communication, and positive displacement pump means for pumping liquid from a selected one of said inlets through a selected one of said outlets; an admixture container for receiving at least one source solution from one of said first and second pump cassettes for forming an admixture solution; and recirculation means comprising means for joining an outlet of the first cassette with an inlet of the second cassette, and the outlet of the second cassette with the admixture container, and the admixture container with the inlet of the first cassette, whereby said first and second pump cassettes are operable to alternately draw said admixture from said admixture container and into said recirculation means for flow into the inlet and pump liquid from the pump cassettes through said recirculation means for flow into said admixture container.
Claim 2
Independent Claim 181 words
An apparatus for compounding an admixture solution from at least one source solution, comprising: first and second pump cassettes, each cassette having a fluid flow path including a plurality of liquid inlets and liquid outlets, the liquid flow path joining said inlets and said outlets in fluid communication, and positive displacement pump means for pumping liquid from a selected one of said inlets through a selected one of said outlets; an admixture container for receiving at least one source solution from one of said first and second pump cassettes for forming an admixture solution; and recirculation means comprising means for joining an outlet of the first cassette with an inlet of the second cassette, and the outlet of the second cassette with the admixture container, and the admixture container with the inlet of the first cassette, whereby said first and second pump cassettes are operable to alternately draw said admixture from said admixture container and into said recirculation means for flow into the inlet and pump liquid from the pump cassettes through said recirculation means for flow into said admixture container.
Claim 3
Dependent Claim 80 words
The apparatus for compounding an admixture in accordance with claim 1, wherein said recirculation means includes first, second, and final tubing conduits, said first tubing conduit joining said liquid outlet in fluid communication with said second and third tubing conduit, said second tubing outlet conduit joining said one liquid inlet in fluid communication with said first and third tubing conduits, and said final tubing conduit joining said admixture container in fluid communication with said first and second tubing outlet conduits.
Claim 4
Dependent Claim 35 words
The apparatus for compounding an admixture in accordance with claim 2, wherein said positive displacement pump means has a predetermined maximum displacement volume which is greater than the volume of said final tubing outlet conduit.
Claim 5
Independent Claim 144 words
A method of compounding a liquid admixture using at least two pump cassettes, each pump cassette have a plurality of liquid inlets joined in fluid communication with a liquid outlet through a liquid flow path, and at least two positive displacement pump means for pumping liquid from a selected one of said inlets to said outlet, said method comprising the steps of: providing an admixture container; providing liquid tubing means for joining said liquid outlet and an upstreammost one of said liquid inlets in fluid communication with said admixture container; compounding a liquid admixture in said admixture container by operating each of said at least two pump means to pump at least one source solution from a downstream one of said liquid inlets through said liquid outlet and into said admixture container; and recirculating said liquid admixture through said at least two pump cassettes.
Claim 6
Independent Claim 144 words
A method of compounding a liquid admixture using at least two pump cassettes, each pump cassette have a plurality of liquid inlets joined in fluid communication with a liquid outlet through a liquid flow path, and at least two positive displacement pump means for pumping liquid from a selected one of said inlets to said outlet, said method comprising the steps of: providing an admixture container; providing liquid tubing means for joining said liquid outlet and an upstreammost one of said liquid inlets in fluid communication with said admixture container; compounding a liquid admixture in said admixture container by operating each of said at least two pump means to pump at least one source solution from a downstream one of said liquid inlets through said liquid outlet and into said admixture container; and recirculating said liquid admixture through said at least two pump cassettes.
Claim 7
Dependent Claim 52 words
The compounding method in accordance with claim 4, wherein said recirculating step comprises: alternately drawing said admixture from said container through said tubing means for flow into said upstream most liquid inlet; and pumping liquid from said at least two pump cassettes through said tubing means for flow into said admixture container.
Claim 8
Dependent Claim 81 words
The compounding method in accordance with claim 5, wherein said liquid tubing means comprises a Y-set tubing assembly including first, second, and third tubing conduits, said first tubing conduit joining said liquid outlet in fluid communication with said second and third tubing conduits, said second tubing conduit joining said upstreammost liquid inlet in fluid communication with said first and third tubing conduit, and said third tubing conduit joining said admixture container in fluid communication with said first and second tubing conduits.
Claim 9
Dependent Claim 43 words
The compounding method in accordance with claim 6, wherein each of said at least two positive displacement pump means has a predetermined maximum displacement volume, said maximum displacement volume being greater than the volume of said third conduit of said Y-set tubing assembly.
Claim 10
Dependent Claim 68 words
The compounding method in accordance with claim 4, wherein said compounding step includes operating each of said at least two pump means to selectively pump each of a plurality of source solutions from respective downstream ones of said liquid inlets, and said recirculating step includes recirculating the liquid admixture being formed through each of said at least two pump cassette after pumping of each of said source solutions.
Claim 11
Dependent Claim 60 words
The compounding method in accordance with claim 4, including flushing said pump cassette with a flush fluid introduced into a fluid inlet disposed in fluid communication with said liquid flow path downstream of said liquid outlet, and reversibly operating said positive displacement pump means so that said flush fluid flows through said flow path and out of said upstreammost inlet.
Claim 12
Dependent Claim 235 words
A fluid pumping apparatus and transfer tubing set for transferring fluids from multiple supply containers to a single receiving container, the pumping apparatus and transfer tubing set comprising: two pumping components, each pumping component having a fluid flow path through the component; a plurality of fluid ports in each fluid flow path of the two pumping components including a fluid outlet port at one end of the flow path, a flush fluid inlet port at the other end of the flow path, and at least one supply fluid inlet port and a fluid recirculation port positioned between said fluid outlet port and said flush fluid inlet port; a plurality of fluid inlet conduits, each inlet conduit connecting one of said multiple supply containers to one of said at least one supply fluid inlet port in each of said two pumping components; two fluid outlet conduits, each outlet conduit connected to a fluid outlet port in each of said two pumping components; means for fluidly coupling the two fluid outlet conduits immediately upstream of the receiving container; a fluid recirculation conduit connecting said fluid recirculation port of one of said two pumping components with the fluid recirculation port of the other of said two pumping components so as to allow fluid flow through the fluid recirculation conduit in selectively alternate directions; and a final fluid outlet conduit fluidly connecting the coupling means with the receiving container.
Claim 13
Dependent Claim 235 words
A fluid pumping apparatus and transfer tubing set for transferring fluids from multiple supply containers to a single receiving container, the pumping apparatus and transfer tubing set comprising: two pumping components, each pumping component having a fluid flow path through the component; a plurality of fluid ports in each fluid flow path of the two pumping components including a fluid outlet port at one end of the flow path, a flush fluid inlet port at the other end of the flow path, and at least one supply fluid inlet port and a fluid recirculation port positioned between said fluid outlet port and said flush fluid inlet port; a plurality of fluid inlet conduits, each inlet conduit connecting one of said multiple supply containers to one of said at least one supply fluid inlet port in each of said two pumping components; two fluid outlet conduits, each outlet conduit connected to a fluid outlet port in each of said two pumping components; means for fluidly coupling the two fluid outlet conduits immediately upstream of the receiving container; a fluid recirculation conduit connecting said fluid recirculation port of one of said two pumping components with the fluid recirculation port of the other of said two pumping components so as to allow fluid flow through the fluid recirculation conduit in selectively alternate directions; and a final fluid outlet conduit fluidly connecting the coupling means with the receiving container.
Claim 14
Dependent Claim 31 words
The fluid pumping apparatus and transfer tubing set of claim 10 wherein said two pumping components are two pumping diaphragm cassettes each having a pumping chamber in the fluid flow path.
Claim 15
Dependent Claim 30 words
The fluid pumping apparatus and transfer tubing set of claim 11 wherein the final fluid outlet conduit has a fluid volume less than the fluid volume of each pumping chamber.
Claim 16
Dependent Claim 45 words
The fluid pumping apparatus and transfer tubing set of claim 12 wherein the two pumping diaphragm cassettes are fluidly connected by the coupling means so as to allow fluid recirculation from the receiving container sequentially though the fluid flow path of each pumping diaphragm cassette.

References Cited (Backward Citations)

US2396043A Cited
US2545445A Cited
US2557334A Cited
US3190321A Cited
US4512764A Cited
US4625494A Cited
US5082014A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1997-04-25 1997-10-25 1998-04-26 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2001-04-25 2001-10-25 2002-04-26 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2005-04-25 2005-10-25 2006-04-26 $7700.00 Window Closed / Lapsed

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