US5300116A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Keratoprosthesis
Assignee: Lions Eye Institute
•
Filing: 1992-08-14
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Granted: 1994-04-05
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Expires: 2012-08-14
Abstract
Abstract A composite device which may be implanted in the cornea of the human eye to replace damaged or diseased portions, and a method of manufacturing the said device, are disclosed. The device consists of a transparent central portion intimately attached to an opaque spongy rim. Both portions are made of hydrogel materials produced in different conditions of polymerization during a two-stage process performed in a specific moulding unit. The spongy rim promotes and maintains cellular invasion from the host corneal tissue, thus providing a tight union between implant and recipient cornea which prevents the postoperative extrusion of the implant.
Inventors
- 👤 Traian V. Chirila
- 👤 Ian J. Constable
- 👤 Geoffrey J. Crawford
- 👤 Albert V. Russo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:34
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/142; Y; Y10; Y10S; Y10S425/00; Y10S425/808
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
49 words
A keratoprosthesis comprising: a central transparent portion which is a hydrogel composed essentially of a biocompatible hydrophilic polymer; and a peripheral portion composed of a porous material which is a hydrogel sponge composed essentially of a biocompatible hydrophilic polymer, said central portion and said peripheral portion being intimately attached.
Claim 2
Dependent Claim
49 words
A keratoprosthesis comprising: a central transparent portion which is a hydrogel composed essentially of a biocompatible hydrophilic polymer; and a peripheral portion composed of a porous material which is a hydrogel sponge composed essentially of a biocompatible hydrophilic polymer, said central portion and said peripheral portion being intimately attached.
Claim 3
Dependent Claim
21 words
A keratoprosthesis as claimed in claim 1, wherein said hydrogel of said central portion is a polymer of 2-hydroxyethyl methacrylate monomer.
Claim 4
Dependent Claim
19 words
A keratoprosthesis as claimed in claim 1, wherein said hydrogel sponge is a polymer of a 2-hydroxyethyl methacrylate monomer.
Claim 5
Dependent Claim
13 words
A keratoprosthesis as claimed in claim 1 having a substantially flat posterior surface.
Claim 6
Dependent Claim
13 words
A keratoprosthesis as claimed in claim 1, having a substantially concave posterior surface.
Claim 7
Dependent Claim
23 words
The keratoprosthesis of claim 1, wherein said hydrogel of said central portion is a polymer of 2-hydroxyethyl methacrylate monomer and a hydrophobic monomer.
Claim 8
Dependent Claim
23 words
The keratoprosthesis of claim 6, wherein said hydrophobic monomer is selected from the group consisting of hydrophobic aliphatic methacrylates and hydrophobic aliphatic acrylates.
Claim 9
Dependent Claim
24 words
The keratoprosthesis of claim 7, wherein said hydrophobic aliphatic methacrylates are selected from the group consisting of methyl methacrylate, cyclohexyl methacrylate or 2-alkoxyethyl methacrylate.
Claim 10
Dependent Claim
13 words
The keratoprosthesis of claim 7, wherein said hydrophobic aliphatic acrylates comprise 2-ethoxyethyl acrylate.
Claim 11
Dependent Claim
32 words
The keratoprosthesis of claim 7, wherein the amount of hydrophobic monomer is about 0% to about 20% by weight of the total weight of said 2-hydroxyethyl methacrylate monomer and said hydrophobic monomer.
Claim 12
Dependent Claim
32 words
The keratoprosthesis of claim 7, wherein the amount of hydrophobic monomer is about 0% to about 20% by weight of the total weight of said 2-hydroxyethyl methacrylate monomer and said hydrophobic monomer.
Claim 13
Dependent Claim
20 words
The keratoprosthesis of claim 1, wherein said hydrogel sponge is a polymer of a 2-hydroxyethyl methacrylate and a hydrophilic monomer.
Claim 14
Dependent Claim
33 words
The keratoprosthesis of claim 12, wherein the amount of said hydrophilic monomer is about 0% to about 50% by weight of the total weight of said 2-hydroxyethyl methacrylate monomer and said hydrophilic monomer.
Claim 15
Dependent Claim
25 words
The keratoprosthesis of claim 12, wherein said hydrophilic monomer is selected from the group consisting of hydroxylated methacrylates, hydroxylated acrylates, acrylamide derivatives and N-vinyl pyrrolidone.
Claim 16
Dependent Claim
21 words
The keratoprosthesis of claim 14, wherein said hydroxylated methacrylates are selected from the group consisting of hydroxypropyl methacrylate and glycerol methacrylate.
Claim 17
Dependent Claim
23 words
The keratoprosthesis of claim 14, wherein said hydroxylated acrylates are selected from the group consisting of 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate and glycerol acrylate.
Claim 18
Dependent Claim
20 words
The keratoprosthesis of claim 1, wherein said hydrogel sponge is a polymer of a 2-hydroxyethyl methacrylate and a hydrophobic monomer.
Claim 19
Dependent Claim
33 words
The keratoprosthesis of claim 17, wherein the amount of said hydrophobic monomer is about 0 to about 5% by weight of the total weight of said 2-hydroxyethyl methacrylate monomer and said hydrophobic monomer.
Claim 20
Dependent Claim
27 words
The keratoprosthesis of claim 17, wherein said hydrophobic monomer is selected from the group consisting of hydrophobic aliphatic methacrylates, hydrophobic aliphatic acrylates, vinyl acetate and vinyl propionate.
Claim 21
Dependent Claim
22 words
The keratoprosthesis of claim 19, wherein said hydrophobic aliphatic methacrylates are selected from the group consisting of methyl methacrylate and 2-alkoxyethyl methacrylate.
Claim 22
Dependent Claim
13 words
The keratoprosthesis of claim 19, wherein said hydrophobic aliphatic acrylates comprise 2-ethoxyethyl acrylate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-04-04 | 1997-10-04 | 1998-04-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-04-04 | 2001-10-04 | 2002-04-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-04-04 | 2005-10-04 | 2006-04-05 | $7700.00 | Window Closed / Lapsed |