US5298487A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Effective ophthalmic irrigation solution
Assignee: Johns Hopkins University
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Filing: 1992-02-10
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Granted: 1994-03-29
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Expires: 2012-02-10
Abstract
Abstract A composition comprising an aqueous phosphate-buffered balanced salt solution including glucose, an antioxidant, and ketone bodies and/or precursors thereof is disclosed. The disclosed composition is particularly useful as an ophthalmic irrigation solution which may be used in ocular surgery, although other uses, for example, ophthalmic topical application and surgeries in general, are also contemplated.
Inventors
- 👤 Chung-Ho Chen
- 👤 Sumi C. Chen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 17:32
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
48 words
A formulation for the preparation of tissues for organ transplant comprising an ophthalmic irrigation solution comprising an aqueous phosphate-buffered balanced salt solution including glucose, an antioxidant, and at least one of ketone bodies and precursors thereof; and a synergistically effective mixture of VEGF, uridine, thymidine and serum-derived factor.
Claim 2
Dependent Claim
48 words
A formulation for the preparation of tissues for organ transplant comprising an ophthalmic irrigation solution comprising an aqueous phosphate-buffered balanced salt solution including glucose, an antioxidant, and at least one of ketone bodies and precursors thereof; and a synergistically effective mixture of VEGF, uridine, thymidine and serum-derived factor.
Claim 3
Dependent Claim
12 words
The formulation of claim 1, wherein the transplanted organ is a cornea.
Claim 4
Dependent Claim
27 words
An irrigation solution for topical application comprising the cornea storage medium according to claim 1 and a synergistically effective mixture of VEGF, uridine, thymidine and serum-derived factor.
Claim 5
Dependent Claim
26 words
An organ culture medium for application comprising the cornea medium according to claim 1 and a synergistically effective mixture of VEGF, uridine, thymidine and serum-derived factor.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-28 | 1997-09-27 | 1998-03-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-28 | 2001-09-27 | 2002-03-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-28 | 2005-09-27 | 2006-03-29 | $7700.00 | Window Closed / Lapsed |