US5296222A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Percutaneous drug delivery system
Assignee: University of Utah
•
Filing: 1992-03-24
•
Granted: 1994-03-22
•
Expires: 2012-03-24
Abstract
Abstract A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e.g. 1-substituted-azacycloheptan-2-one), and propylene glycol to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drug(s); occluding the area of skin during the application; and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the described treatment.
Inventors
- 👤 Robert V. Petersen
- 👤 Tsung-Min Hsu
- 👤 Han-Chen Lee
- 👤 Don Christy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:24
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K47/00; A61K47/30; A61K47/42
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
44 words
A percutaneous permeation enhancer comprising an enzyme component including a proteolytic enzyme selected to enhance the penetration of a chemical agent through skin in admixture with a potentiating amount of a non-enzymatic compound for enhancing the penetration of said chemical agent through said skin.
Claim 2
Dependent Claim
44 words
A percutaneous permeation enhancer comprising an enzyme component including a proteolytic enzyme selected to enhance the penetration of a chemical agent through skin in admixture with a potentiating amount of a non-enzymatic compound for enhancing the penetration of said chemical agent through said skin.
Claim 3
Dependent Claim
22 words
The percutaneous permeation enhancer of claim 1 further including a solubilizer for solubilizing said components of said permeation enhancer into a solvent.
Claim 4
Dependent Claim
34 words
The percutaneous permeation enhancer of claim 2 further including propylene glycol in admixture with said enzyme component and said non-enzymatic compound, said propylene glycol further enhancing the penetration of said chemical through said skin.
Claim 5
Dependent Claim
20 words
The percutaneous permeation enhancer of claim 1 wherein said enzyme is papain and wherein said papain is solubilized in water.
Claim 6
Dependent Claim
23 words
The percutaneous permeation enhancer of claim 4 wherein said papain in water has a concentration of about 0.019 mg/ml to about 0.093 mg/ml.
Claim 7
Dependent Claim
34 words
The percutaneous permeation enhancer of claim 5 wherein said non-enzymatic compound is a lactam compound having the structural formula ##STR2## where R is selected from the group consisting of alkyl, aryl and phenyl groups.
Claim 8
Dependent Claim
14 words
The percutaneous permeation enhancer of claim 6 wherein said lactam compound is a 1-substituted-azacycloheptan-2-one.
Claim 9
Dependent Claim
13 words
The percutaneous permeation enhancer of claim 7 wherein said lactam compound is 1-n-Dodecylazacycloheptan-2-one.
Claim 10
Dependent Claim
20 words
The percutaneous permeation enhancer of claim 5 wherein said non-enzymatic compound s a combination of ethyl acetate and ethyl alcohol.
Claim 11
Dependent Claim
14 words
The percutaneous permeation enhancer of claim 5 wherein said non-enzymatic compound is ethyl alcohol.
Claim 12
Dependent Claim
13 words
The percutaneous permeation enhancer of claim 5 wherein said non-enzymatic compound is dioxolane.
Claim 13
Dependent Claim
20 words
The percutaneous permeation enhancer of claim 5 wherein said non-enzymatic compound is a combination of caprylic acid and capric triglyceride.
Claim 14
Dependent Claim
15 words
The percutaneous permeation enhancer of claim 5 wherein said non-enzymatic compound is n-decyl methyl sulfoxide.
Claim 15
Dependent Claim
14 words
The percutaneous permeation enhancer of claim 5 wherein said non-enzymatic compound is a surfactant.
Claim 16
Dependent Claim
24 words
The percutaneous permeation enhancer of claim 1 wherein said proteolytic enzyme is selected from the group consisting of papain, bromelain, pepsin, trypsin and pancreatin.
Claim 17
Dependent Claim
47 words
The percutaneous permeation enhancer of claim 15 wherein said enzyme is papain, said papain being solubilized in water in a concentration of about 0.019 mg/ml to about 0.093 mg/ml, and wherein said non-enzymatic compound includes ethanol in a concentration of about thirty percent to about fifty percent.
Claim 18
Dependent Claim
47 words
The percutaneous permeation enhancer of claim 3 wherein said enzyme is papain, said papain being solubilized in water in a concentration of bout 0.019 mg/ml to about 0.093 mg/ml, and wherein said non-enzymatic compound includes ethanol in a concentration of about thirty percent to about fifty percent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-21 | 1997-09-20 | 1998-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-21 | 2001-09-20 | 2002-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-21 | 2005-09-20 | 2006-03-22 | $7700.00 | Window Closed / Lapsed |