Patent EP0680072A2 successfully refreshed from Google Patents.
US5286474A
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Use of carotenoporphyrins as tumor localizing agents for diagnosis
Assignee: Arizona State University
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Filing: 1992-10-22
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Granted: 1994-02-15
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Expires: 2012-10-22
Abstract
Abstract A process of tumor identification comprising administering a carotenoporphyrin to a tumor-bearing mammalian host and irradiating the mammalian host with light whereupon the carotenoporphyrin, which has been preferentially taken up by the tumor tissue, fluoresces and permits precise identification of the location, size and shape of the tumor tissue. An improved process of synthesizing carotenoporphyrins 1-5 is also provided.
Inventors
- 👤 John D. Gust, Jr.
- 👤 Ana L. Moore
- 👤 Thomas A. Moore
- 👤 Giulio Jori
- 👤 Elena Reddi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:44
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/001; A61K49/0013; A61K49/0017; A61K49/0019; A61K49/0021; A61K49/0036; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K49/005; A61K49/0052; C; C07; C07D; C07D487/00; C07D487/22; Y; Y10; Y10S; Y10S436/00; Y10S436/80
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
67 words
A method of locating a diagnostic agent in and visualizing non-hepatic and non-splenic tumor tissue in a mammalian host comprising: administering to a mammalian host an effective amount of a carotenoporphyrin represented by the formula: ##STR3## permitting said carotenoporphyrin to localize in the tumor tissue; and thereafter exposing said mammalian host to light whereby said carotenoporphyrin fluoresces permitting precise visualization of the tumor location, size and shape.
Claim 2
Independent Claim
67 words
A method of locating a diagnostic agent in and visualizing non-hepatic and non-splenic tumor tissue in a mammalian host comprising: administering to a mammalian host an effective amount of a carotenoporphyrin represented by the formula: ##STR3## permitting said carotenoporphyrin to localize in the tumor tissue; and thereafter exposing said mammalian host to light whereby said carotenoporphyrin fluoresces permitting precise visualization of the tumor location, size and shape.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein said carotenoporphyrin is administered intravenously prior to initiation of a diagnostic or surgical procedure.
Claim 4
Dependent Claim
15 words
The method of claim 2 wherein said carotenoporphyrin is administered intravenously as a solubilized emulsion.
Claim 5
Dependent Claim
15 words
The method of claim 2 wherein said carotenoporphyrin is incorporated into liposomes prior to administration.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein said carotenoporphyrin is carotenoporphyrin 1.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein said carotenoporphyrin is carotenoporphyrin 2.
Claim 8
Dependent Claim
11 words
The method of claim 1 wherein said carotenoporphyrin is carotenoporphyrin 3.
Claim 9
Dependent Claim
11 words
The method of claim 1 wherein said carotenoporphyrin is carotenoporphyrin 4.
Claim 10
Dependent Claim
11 words
The method of claim 1 wherein said carotenoporphyrin is carotenoporphyrin 5.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-02-14 | 1997-08-16 | 1998-02-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-02-14 | 2001-08-16 | 2002-02-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-02-14 | 2005-08-16 | 2006-02-15 | $7700.00 | Window Closed / Lapsed |