US5282982A
Expired / Lapsed
US
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Blood washing method
Assignee: Bard AutoTransfusion Acquisition Corp
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Filing: 1991-07-12
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Granted: 1994-02-01
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Expires: 2011-07-12
Abstract
Abstract A blood washing device is employed for recovering shed blood or other sources of blood and preparing packed red cells therefrom. The device employs a gravity sedimentation procedure but achieves a shortened washing period by using an aggregating reagent for aggregating or agglomerating the red cells so as to increase their sedimentation velocity during the gravity sedimentation. The wash period is further shortened by employing a vessel with a flat shallow configuration for shortening the sedimentation path length of the aggregated red cells. A non-turbulant removal of the resultant broad shallow layer of sedimented red cells is achieved by carefully tilting the vessel after the sedimentation step so as to induce the sedimented red cells to slide or shift into a funnel configuration within the vessel. After the red cells have shifted into a funnel configuration, they are allowed to stand in that configuration so as undergo further concentration. As the red cells become packed, an elutriation of the intercellular fluids occurs. The resultant packed red cells are then carefully drained from the bottom of the funnel configuration for reinfusion into the patient. The period of the wash cycle is sufficiently short that a patient's shed blood can often be recovered during an operation and then washed and reinfused into the same patient during the same operation or shortly thereafter. Autologous transfusions are useful in cases where there is a shortage of blood or where the safety of donor blood is in question.
Inventors
- 👤 John R. Wells
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:08
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/02; A61M1/36; A61M1/3607; A61M1/3609; A61M1/3612; A61M1/3621; A61M1/3692; A61M1/3693; A61M1/3695; A61M1/71; A61M1/78; A61M1/782; A61M1/784; B; B01; B01D; B01D21/00; B01D21/0015; A61M1/025
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
215 words
A method for recovering a blood mixture and preparing packed red cells therefrom, the method comprising the following steps: Step A: transferring the blood mixture into a reservoir; Step B: loading a reagent into the reservoir for aggregating red cells; then Step C: blending the blood mixture with the reagent for aggregating red cells within the reservoir; then Step D: separating the aggregated red cells from the blended blood mixture by gravity sedimentation in an accelerated fashion by orienting the reservoir into a flat shallow configuration and allowing the aggregated red cells to sediment from the blended blood mixture into a flat shallow layer of sedimented red cells; then Step E: slowly shifting the flat shallow layer of sedimented red cells to a funnel configuration without mixing by slowly reorienting the reservoir from the flat shallow configuration to the funnel configuration; then Step F: packing the shifted sedimented red cells within the funnel configuration by retaining the reservoir in the funnel configuration for allowing the sedimented red cells to become packed therein; then Step G: removing the packed red cells from the blended blood mixture while continuing to retain the reservoir in the funnel configuration by pumping the packed red cells from an exit port at the bottom of the funnel configuration of the reservoir.
Claim 2
Independent Claim
215 words
A method for recovering a blood mixture and preparing packed red cells therefrom, the method comprising the following steps: Step A: transferring the blood mixture into a reservoir; Step B: loading a reagent into the reservoir for aggregating red cells; then Step C: blending the blood mixture with the reagent for aggregating red cells within the reservoir; then Step D: separating the aggregated red cells from the blended blood mixture by gravity sedimentation in an accelerated fashion by orienting the reservoir into a flat shallow configuration and allowing the aggregated red cells to sediment from the blended blood mixture into a flat shallow layer of sedimented red cells; then Step E: slowly shifting the flat shallow layer of sedimented red cells to a funnel configuration without mixing by slowly reorienting the reservoir from the flat shallow configuration to the funnel configuration; then Step F: packing the shifted sedimented red cells within the funnel configuration by retaining the reservoir in the funnel configuration for allowing the sedimented red cells to become packed therein; then Step G: removing the packed red cells from the blended blood mixture while continuing to retain the reservoir in the funnel configuration by pumping the packed red cells from an exit port at the bottom of the funnel configuration of the reservoir.
Claim 3
Dependent Claim
55 words
A method for recovering a blood mixture and preparing packed red cells therefrom, as described in claim 1, wherein: in said Step A, the reservoir being oriented within a collecting configuration for visualing the fullness of the reservoir by means of one or more demarcations thereon as the blood mixture is collected into the reservoir.
Claim 4
Independent Claim
245 words
A method for recovering a blood mixture and preparing packed red cells therefrom, the method comprising the following steps: Step A: aspirating the blood mixture into a reservoir attached to a blood washing device; Step B: adding a reagent for aggregating red cells into the reservoir; then Step C: blending the blood mixture with the reagent for aggregating red cells by rocking the reservoir on the blood washing device; then Step D: accelerating the separation of the aggregated red cells from the blood mixture by gravity sedimentation employing the blood washing device to reorient the reservoir in a sedimentation position and retaining the reservoir thereat until the red cells have had an opportunity to sediment from the blood mixture into a flat shallow layer of sedimented red cells; then Step E: slowly easing the reservoir from the sedimentation position to a funnel position by means of the blood washing device for slowly shifting the flat shallow layer of sedimented red cells into a funnel configuration without mixing the sedimented red cells with the blood mixture; then Step F: holding the reservoir within the funnel position for allowing the red cells to become packed therein; then Step G: removing the packed red cells from the reservoir while the blood washing device retains the reservoir in the funnel position; and then Step H: stopping the further removal of material from the reservoir after a sensor senses that the reservoir has been substantially exhausted of packed red cells.
Claim 5
Independent Claim
245 words
A method for recovering a blood mixture and preparing packed red cells therefrom, the method comprising the following steps: Step A: aspirating the blood mixture into a reservoir attached to a blood washing device; Step B: adding a reagent for aggregating red cells into the reservoir; then Step C: blending the blood mixture with the reagent for aggregating red cells by rocking the reservoir on the blood washing device; then Step D: accelerating the separation of the aggregated red cells from the blood mixture by gravity sedimentation employing the blood washing device to reorient the reservoir in a sedimentation position and retaining the reservoir thereat until the red cells have had an opportunity to sediment from the blood mixture into a flat shallow layer of sedimented red cells; then Step E: slowly easing the reservoir from the sedimentation position to a funnel position by means of the blood washing device for slowly shifting the flat shallow layer of sedimented red cells into a funnel configuration without mixing the sedimented red cells with the blood mixture; then Step F: holding the reservoir within the funnel position for allowing the red cells to become packed therein; then Step G: removing the packed red cells from the reservoir while the blood washing device retains the reservoir in the funnel position; and then Step H: stopping the further removal of material from the reservoir after a sensor senses that the reservoir has been substantially exhausted of packed red cells.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-31 | 1997-08-02 | 1998-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-31 | 2001-08-02 | 2002-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-31 | 2005-08-02 | 2006-02-01 | $7700.00 | Window Closed / Lapsed |