US5280548A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Emission based fiber optic sensors for pH and carbon dioxide analysis
Assignee: Becton Dickinson Critical Care Systems Pte Ltd
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Filing: 1993-03-11
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Granted: 1994-01-18
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Expires: 2013-03-11
Abstract
Abstract The present invention is directed to a fiber optic sensor for analyzing pH which comprises (a) a fluorescence-based fiber optic sensor; and (b) a fluorescent dye-polymeric matrix in contact with the sensor, wherein the fluorescent dye is seminaphthorhodaflor-1-isothiocyanate, the polymer is a hydrogel selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, dextrans, and polysaccharides, and the dye is chemically bonded to the polymer. The present invention is also directed to a fiber optic sensor for analyzing carbon dioxide which comprises (a) a fluorescence-based fiber optic sensor; and (b) a fluorescent dye-polymeric-silicone elastomeric matrix in contact with the sensor, wherein the matrix comprises a fluorescent dye-polymeric premixture in a silicone elastomer, and the fluorescent dye is selected from the group consisting of seminaphthorhodaflor-1-carboxylate (SNARF-1C), seminaphthorhodaflor-1-isothiocyanate (SNARF-1C-ITC), seminaphthorhodaflor-1-dextran conjugate (SNARF-1C-Dex), 10-diethylamino seminaphthorhodaflor-1-carboxylate (SNARF-2C), and seminaphthorhodaflor-1-carboxylate 10-acetate (SNAFL-1C diacetate), the polymer is a hydrogel selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, dextrans, and polysaccharides, and the silicone elastomer is a polydimethyl siloxane selected from the group consisting of hydroxy, epoxy, and vinyl terminated polydimethyl siloxanes.
Inventors
- 👤 Beauford W. Atwater
- 👤 Olga Laksin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:33
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; G01N21/62; G01N21/63; G01N21/64; G01N21/6408; G01N21/6428; G01N2021/6434; G01N2021/7706; G01N2021/772; G01N2021/773; G01N2021/7769; G01N2021/7786; G01N21/78; G01N21/80; G01N31/00; G01N31/22; G01N31/221
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
58 words
A fiber optic sensor for analyzing pH which comprises: (a) a fluorescence-based fiber optic sensor; and (b) a fluorescent dye-polymeric matrix in contact with the sensor, wherein the fluorescent dye is seminaphthorhodaflor-1-isothiocyanate, the polymer is a hydrogel selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, dextrans, and polysaccharides, and the dye is chemically bonded to the polymer.
Claim 2
Dependent Claim
58 words
A fiber optic sensor for analyzing pH which comprises: (a) a fluorescence-based fiber optic sensor; and (b) a fluorescent dye-polymeric matrix in contact with the sensor, wherein the fluorescent dye is seminaphthorhodaflor-1-isothiocyanate, the polymer is a hydrogel selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, dextrans, and polysaccharides, and the dye is chemically bonded to the polymer.
Claim 3
Dependent Claim
23 words
The fiber optic sensor according to claim 1, wherein the polymer is selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, and dextrans.
Claim 4
Dependent Claim
21 words
The fiber optic sensor according to claim 2, wherein the polymer is selected from the group consisting of polyhydroxyethylmethacrylate and polyvinylpyrrolidone.
Claim 5
Dependent Claim
30 words
The fiber optic sensor according to claim 1, wherein the fluorescent dye is present in the fluorescent dye-polymeric matrix in an amount from about 0.01% to about 1%, by weight.
Claim 6
Dependent Claim
30 words
The fiber optic sensor according to claim 4, wherein the fluorescent dye is present in the fluorescent dye-polymeric matrix in an amount from about 0.01% to about 0.5%, by weight.
Claim 7
Dependent Claim
26 words
The fiber optic sensor according to claim 1, wherein the fluorescent dye-polymeric matrix has a pK a in the range from about 6.5 to about 10.
Claim 8
Dependent Claim
104 words
A fiber optic sensor for analyzing carbon dioxide which comprises: (a) a fluorescence-based fiber optic sensor; and (b) a fluorescent dye-polymeric-silicone elastomeric matrix in contact with the sensor, wherein the matrix comprises a fluorescent dye-polymeric premixture in a silicone elastomer, and the fluorescent dye is selected from the group consisting of seminaphthorhodaflor-1-carboxylate (SNARF-1C)), seminaphthorhodaflor-1-isothiocyanate (SNARF-1C-ITC), seminaphthorhodaflor-1-dextran conjugate (SNARF-1C-Dex), 10-diethylamino seminaphthorhodaflor-1-carboxylate (SNARF-2C), and seminaphthorhodaflor-1-carboxylate 10-acetate (SNAFL-1C diacetate), the polymer is a hydrogel selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, dextrans, and polysaccharides, and the silicone elastomer is a polydimethyl siloxane selected from the group consisting of hydroxy, epoxy, and vinyl terminated polydimethyl siloxanes.
Claim 9
Dependent Claim
104 words
A fiber optic sensor for analyzing carbon dioxide which comprises: (a) a fluorescence-based fiber optic sensor; and (b) a fluorescent dye-polymeric-silicone elastomeric matrix in contact with the sensor, wherein the matrix comprises a fluorescent dye-polymeric premixture in a silicone elastomer, and the fluorescent dye is selected from the group consisting of seminaphthorhodaflor-1-carboxylate (SNARF-1C)), seminaphthorhodaflor-1-isothiocyanate (SNARF-1C-ITC), seminaphthorhodaflor-1-dextran conjugate (SNARF-1C-Dex), 10-diethylamino seminaphthorhodaflor-1-carboxylate (SNARF-2C), and seminaphthorhodaflor-1-carboxylate 10-acetate (SNAFL-1C diacetate), the polymer is a hydrogel selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, dextrans, and polysaccharides, and the silicone elastomer is a polydimethyl siloxane selected from the group consisting of hydroxy, epoxy, and vinyl terminated polydimethyl siloxanes.
Claim 10
Dependent Claim
24 words
The fiber optic sensor according to claim 7, wherein the fluorescent dye is selected from the group consisting of seminaphthorhodaflor-1-carboxylate, seminaphthorhodaflor-1-isothiocyanate, and seminaphthorhodaflor-1-dextran conjugate.
Claim 11
Dependent Claim
14 words
The fiber optic sensor according to claim 8, wherein the fluorescent dye is seminaphthorhodaflor-1-carboxylate.
Claim 12
Dependent Claim
23 words
The fiber optic sensor according to claim 7, wherein the polymer is selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, cellulose, and dextrans.
Claim 13
Dependent Claim
21 words
The fiber optic sensor according to claim 10, wherein the polymer is selected from the group consisting of polyhydroxyethylmethacrylate and polyvinylpyrrolidone.
Claim 14
Dependent Claim
25 words
The fiber optic sensor according to claim 7, wherein the silicone elastomer is selected from the group consisting of epoxy and vinyl terminated polydimethyl siloxanes.
Claim 15
Dependent Claim
18 words
The fiber optic sensor according to claim 12, wherein the silicone elastomer is a vinyl terminated polydimethyl siloxane.
Claim 16
Dependent Claim
30 words
The fiber optic sensor according to claim 7, wherein the fluorescent dye is present in the fluorescent dye-polymeric premix in an amount from about 0.1% to about 10%, by weight.
Claim 17
Dependent Claim
30 words
The fiber optic sensor according to claim 14, wherein the fluorescent dye is present in the fluorescent dye-polymeric premix in an amount from about 0.5% to about 5%, by weight.
Claim 18
Dependent Claim
32 words
The fiber optic sensor according to claim 7, wherein the fluorescent dye-polymeric premix is present in the fluorescent dye-polymeric-silicone elastomeric matrix in an amount from about 1% to about 30%, by weight.
Claim 19
Dependent Claim
32 words
The fiber optic sensor according to claim 16, wherein the fluorescent dye-polymeric premix is present in the fluorescent dye-polymeric-silicone elastomeric matrix in an amount from about 5% to about 25%, by weight.
Claim 20
Dependent Claim
26 words
The fiber optic sensor according to claim 7, wherein the fluorescent dye-polymeric premixture has a pK a in the range from about 7 to about 9.
Claim 21
Dependent Claim
32 words
The fiber optic sensor according to claim 7, wherein the fluorescent dye-polymeric premixture is present in the silicone elastomer as a fine dispersion in the range of about 1 to 10 microns.
References Cited (Backward Citations)
US5127730A
Cited
US5196709A
Cited
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