US5277910A
Expired / Lapsed
US
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Process for the preparation of a pharmaceutical composition selectively lowering the blood-lipid level
Assignee: Individual
•
Filing: 1992-12-11
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Granted: 1994-01-11
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Expires: 2012-12-11
Abstract
Abstract The invention relates to a process for the preparation of a selective blood-lipid-level-lowering pharmaceutical composition by extraction of the seed, root, stalk and/or leaves of alfalfa. According to the process of the invention, the extraction is carried out with water or an aqueous solution of a temperature of at least 40 degrees C. and a pH of at most 8, whereafter the extract obtained is transformed alone or together with hardly or not digestible polysaccharides and optionally with carriers commonly used in the pharmaceutical industry to a pharmaceutical composition. The composition according to the invention contains neither canavanine (being a toxic amino acid) nor coumestrol (possessing hormone effect).
Inventors
- 👤 Mate Hidvegi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:58
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K36/00; A61K36/18; A61K36/185; A61K36/48; A61P; A61P3/00; A61P3/06; A61P3/12; A61P3/14
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
60 words
A process for the preparation of a selective blood-lipid-level-lowering pharmaceutical composition, which comprises extracting the seed, root, stalk or leaves of alfalfa with water or an aqueous solution at a temperature of at least 40° C. and a pH of at most 8, the resulting extract containing at most 1 ppm of canavanin and at most 9 ppm of coumestrol.
Claim 2
Dependent Claim
60 words
A process for the preparation of a selective blood-lipid-level-lowering pharmaceutical composition, which comprises extracting the seed, root, stalk or leaves of alfalfa with water or an aqueous solution at a temperature of at least 40° C. and a pH of at most 8, the resulting extract containing at most 1 ppm of canavanin and at most 9 ppm of coumestrol.
Claim 3
Dependent Claim
28 words
A process as defined in claim 1, which comprises carrying out the extraction with an aqueous solution at a temperature of 50°-120° C. and a pH of 5.5-6.5.
Claim 4
Dependent Claim
28 words
A process as defined in claim 2, which comprises carrying out the extraction with an aqueous solution at a temperature of 60°-70° C. and a pH of 5.8-6.2.
Claim 5
Dependent Claim
21 words
A process as defined in claim 1, wherein the aqueous solution comprises hydrochloric, acetic, citric, malic, tartaric, succinic or ascorbic acid.
Claim 6
Dependent Claim
37 words
A process as defined in claim 1, wherein the aqueous solution comprises the salt of hydrochloric, acetic, citric, malic, tartaric, succinic, ascorbic or sulfuric acid formed with iron, magnesium, calcium, manganese, selenium, zinc, cobalt or copper ions.
Claim 7
Dependent Claim
31 words
A process as defined in claim 1 wherein the aqueous solution comprises the salt of iron, magnesium, calcium, manganese, selenium, zinc, cobalt or copper ion formed with aspartic or glutamic acid.
Claim 8
Dependent Claim
16 words
A process as defined in claim 1 wherein the aqueous solution comprises an acidic buffer solution.
Claim 9
Dependent Claim
38 words
A process as defined in claim 1 wherein the aqueous solution comprises acetic acid and sodium acetate, potassium dihydrogen phosphate and disodium hydrogen phosphate, disodium hydrogen phosphate and citric acid or sodium acetate as an acidic buffer solution.
Claim 10
Dependent Claim
13 words
A process as defined in claim 1, in which the extract is concentrated.
Claim 11
Dependent Claim
20 words
A process as defined in claim 9, in which a dried powder or granulate is prepared from the concentrated extract.
Claim 12
Dependent Claim
13 words
A selective blood-lipid-level-lowering composition prepared by the process as defined in claim 1.
Claim 13
Dependent Claim
37 words
The composition of claim 11, wherein the active ingredients, either alone or together with polysaccharides which are not digestible, or only slightly so, are mixed with pharmaceutically acceptable carriers, wetting agents, sweeteners, aromatizers, buffers or mixtures thereof.
Claim 14
Dependent Claim
23 words
An alfalfa extract for selectively lowering the blood-lipid level, containing at most 1 ppm of canavanin and at most 9 ppm of coumestrol.
Claim 15
Dependent Claim
23 words
An alfalfa extract for selectively lowering the blood-lipid level, containing at most 1 ppm of canavanin and at most 9 ppm of coumestrol.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-10 | 1997-07-12 | 1998-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-10 | 2001-07-12 | 2002-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-10 | 2005-07-12 | 2006-01-11 | $7700.00 | Window Closed / Lapsed |