US5270472A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the process of learning and memory and for the treatment of coma
Assignee: Sigma Tau Industrie Farmaceutiche Riunite SpA
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Filing: 1992-05-15
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Granted: 1993-12-14
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Expires: 2012-05-15
Abstract
Abstract Amides of alkanoyl L-carnitines of general formula (1). ##STR1## wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl; R' is the monovalent residue of a naturally occurring aminoacid selected from: ##STR2## X - is the anion of a pharmacologically acceptable acid are active in regenerating the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma. Orally or parenterally administrable compositions in unit dosage form comprise between about 50 and about 500 mg of an amide of formula (1).
Inventors
- 👤 Giulio Taglialatela
- 👤 Nicola Fanto
- 👤 Mose Santaniello
- 👤 Claudio Cavazza
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:46
CPC Classifications
C; C07; C07C; C07C279/00; C07C279/04; C07C279/14; C07C237/00; C07C237/02; C07C237/04; C07C237/12; C07C237/22; C07C275/00; C07C275/04; C07C275/06; C07C275/16
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
74 words
An amide of alkanoyl L-carnitine of Formula (I): ##STR15## wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from the group consisting of acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl; R' is the monovalent residue of a naturally occurring aminoacid selected from the group consisting of: ##STR16## and X - is the anion of a pharmacologically acceptable salt.
Claim 2
Dependent Claim
74 words
An amide of alkanoyl L-carnitine of Formula (I): ##STR15## wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from the group consisting of acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl; R' is the monovalent residue of a naturally occurring aminoacid selected from the group consisting of: ##STR16## and X - is the anion of a pharmacologically acceptable salt.
Claim 3
Dependent Claim
32 words
The amide of claim 1, wherein X - is selected from chloride, bromide, iodide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulphate and glucosephosphate.
Claim 4
Dependent Claim
13 words
The amide of claim 1, wherein R is acetyl and R' is ##STR17##
Claim 5
Dependent Claim
13 words
The amide of claim 1, wherein R is propionyl and R' is ##STR18##
Claim 6
Dependent Claim
13 words
The amide of claim 1, wherein R is isovaleryl and R' is ##STR19##
Claim 7
Dependent Claim
13 words
The amide of claim 1, wherein R is acetyl and R' is ##STR20##
Claim 8
Dependent Claim
13 words
The amide of claim 1, wherein R is acetyl and R' is ##STR21##
Claim 9
Dependent Claim
13 words
The amide of claim 1, wherein R is acetyl and R' is ##STR22##
Claim 10
Dependent Claim
13 words
The amide of claim 1, wherein R is acetyl and R' is ##STR23##
Claim 11
Dependent Claim
14 words
The amide of anyone of claim 3 to 9, wherein X - is chloride.
Claim 12
Dependent Claim
14 words
A amide of claim 9, wherein the amino acid radical is in zwitterionic form.
Claim 13
Dependent Claim
21 words
An orally or parenterally administrable pharmaceutical composition comprising an amide of claim 1, as active ingredient and a pharmacologically acceptable excipient.
Claim 14
Dependent Claim
44 words
An orally or parenterally administrable pharmaceutical composition for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma, comprising an amide of claim 1, as active ingredient and a pharmacologically acceptable excipient.
Claim 15
Dependent Claim
23 words
The composition of claim 13 in unit dosage form comprising between about 50 and about 500 mg of an amide of claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-12-13 | 1997-06-14 | 1997-12-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-12-13 | 2001-06-14 | 2001-12-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-12-13 | 2005-06-14 | 2005-12-14 | $7700.00 | Window Closed / Lapsed |