US5262319A
Expired / Lapsed
US
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Method for obtaining bone marrow free of tumor cells using transforming growth factor β3
Assignee: OSI Pharmaceuticals LLC
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Filing: 1990-06-25
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Granted: 1993-11-16
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Expires: 2010-06-25
Abstract
Abstract The present invention provides (1) an antibody which (a) specifically binds to human TGF- beta 3 and (b) exhibits substantially no cross reactivity with TGF- beta 1 or TGF- beta 2 and (2) antibodies directed against the pro region of the TGF- beta precursor. Further, this invention provides a pharmaceutical composition comprising the pro region of the TGF- beta precursor. Also, this invention provides methods for diagnosing, detecting and treating subjects suffering from disorders associated with TGF- beta 3.
Inventors
- 👤 Kenneth K. Iwata
- 👤 J. Gordon Foulkes
- 👤 Peter T. Dijke
- 👤 John D. Haley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:41
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/44; A61K35/48; A61K35/50; A61P; A61P17/00; A61P25/00; A61P29/00; A61P31/00; A61P31/12; A61P35/00; A61P37/00; A61P37/02; A61P37/04; A61P43/00; A61P9/00; A61P9/10; A61P9/12; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/495; C07K14/52; C07K16/00; C07K16/18; C07K16/22; C07K16/24; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; A61K38/00; C07K2317/00; C07K2317/30; C07K2317/34; C07K2319/00; C07K2319/70; C07K2319/74; C07K2319/75; G01N2333/00; G01N2333/435; G01N2333/475; G01N2333/495
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
98 words
A method for obtaining bone marrow essentially free of actively dividing tumor cells which comprises: (a) contacting for 24 hours bone marrow containing hematopoietic cells and actively growing tumor cells with a concentration of a TGF-β3 at 1000 pM such that the growth of the normal hematopoietic cells is temporarily inhibited; (b) after 24 hours contacting bone marrow with a tumor inhibiting drug so that growth of the tumor cells is permanently prevented; and (c) culturing bone marrow so as to permit growth of normal hematopoietic cells thereby obtaining bone marrow essentially free of actively dividing tumor cells.
Claim 2
Independent Claim
98 words
A method for obtaining bone marrow essentially free of actively dividing tumor cells which comprises: (a) contacting for 24 hours bone marrow containing hematopoietic cells and actively growing tumor cells with a concentration of a TGF-β3 at 1000 pM such that the growth of the normal hematopoietic cells is temporarily inhibited; (b) after 24 hours contacting bone marrow with a tumor inhibiting drug so that growth of the tumor cells is permanently prevented; and (c) culturing bone marrow so as to permit growth of normal hematopoietic cells thereby obtaining bone marrow essentially free of actively dividing tumor cells.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-11-15 | 1997-05-17 | 1997-11-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-11-15 | 2001-05-17 | 2001-11-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-11-15 | 2005-05-17 | 2005-11-16 | $7700.00 | Window Closed / Lapsed |