US5258172A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Iodinated aliphatic emulsions for X-ray contrast
Assignee: Individual
•
Filing: 1990-08-15
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Granted: 1993-11-02
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Expires: 2010-08-15
Abstract
Abstract Contrast agents comprising stable aqueous emulsions of iophendylate and their use in radiological examination of the small and large intestine after oral administration are described.
Inventors
- 👤 Daniel L. Rubin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 04:16
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0495
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
107 words
A process for visualization of the GI tract of a mammal comprising administering to the mammal a diagnostically effective amount of a contrast agent comprising an aqueous emulsion of an iodinated compound which iodinated compound is an aliphatic carboxylic acid of from 6-17 carbon atoms in the aliphatic chain exclusive of any branching in said aliphatic chain, said carboxylic acid being (a) iodinated directly or by incorporation therein of an iodinated substituent and (b) slightly soluble in water and which emulsion shows no visible evidence of separation into oil and water phases in the GI tract for at least about one hour as demonstrated by radiographic examination.
Claim 2
Dependent Claim
107 words
A process for visualization of the GI tract of a mammal comprising administering to the mammal a diagnostically effective amount of a contrast agent comprising an aqueous emulsion of an iodinated compound which iodinated compound is an aliphatic carboxylic acid of from 6-17 carbon atoms in the aliphatic chain exclusive of any branching in said aliphatic chain, said carboxylic acid being (a) iodinated directly or by incorporation therein of an iodinated substituent and (b) slightly soluble in water and which emulsion shows no visible evidence of separation into oil and water phases in the GI tract for at least about one hour as demonstrated by radiographic examination.
Claim 3
Dependent Claim
20 words
A process according to claim 1 wherein the carboxylic acid has an aromatic substituent to which the iodine is bound.
Claim 4
Dependent Claim
51 words
A process according to claim 2 wherein the iodinated compound is of the formula (I) n X--R--CO 2 H wherein X is an aromatic group, n is an integer of from 1-3 per aromatic nucleus and R is an aliphatic group of from 5 to 16 carbon atoms exclusive of branching.
Claim 5
Dependent Claim
13 words
A process according to claim 3 wherein the iodinated compound is iodoundecylenic acid.
Claim 6
Dependent Claim
122 words
A process for visualization of the GI tract of a mammal comprising administering to the mammal a diagnostically effective amount of a contrast agent comprising an aqueous emulsion of an iodinated compound convertible at least in part in the GI tract to an aliphatic carboxylic acid of from 6 to 17 carbon atoms in the aliphatic chain exclusive of any branching in the aliphatic chain, which compound is (a) iodinated directly in the aliphatic chain of the carboxylic acid or by incorporation therein of an iodinated substituent and (b) slightly soluble in water and which emulsion shows no visible evidence of separation into oil and water phases in the GI tract for at least about one hour as demonstrated by radiographic examination.
Claim 7
Dependent Claim
122 words
A process for visualization of the GI tract of a mammal comprising administering to the mammal a diagnostically effective amount of a contrast agent comprising an aqueous emulsion of an iodinated compound convertible at least in part in the GI tract to an aliphatic carboxylic acid of from 6 to 17 carbon atoms in the aliphatic chain exclusive of any branching in the aliphatic chain, which compound is (a) iodinated directly in the aliphatic chain of the carboxylic acid or by incorporation therein of an iodinated substituent and (b) slightly soluble in water and which emulsion shows no visible evidence of separation into oil and water phases in the GI tract for at least about one hour as demonstrated by radiographic examination.
Claim 8
Dependent Claim
20 words
A process according to claim 5 wherein the aliphatic chain has an aromatic substituent to which the iodine is bound.
Claim 9
Dependent Claim
62 words
A process according to claim 6 wherein the iodinated compound is a compound convertible at least in part into a carboxylic acid of the formula (I) n X--R--CO 2 H wherein X is an aromatic group, n is an integer of from 1-3 per aromatic nucleus and R is an aliphatic group of from 5 to 16 carbon atoms exclusive of branching.
Claim 10
Dependent Claim
27 words
A process according to claim 5 wherein the iodinated compound convertible into the carboxylic acid is an ester, amide, anhydride or acid halide of the carboxylic acid.
Claim 11
Dependent Claim
70 words
A process according to claim 7 wherein the compound has the formula (I) n X--R--CO--R' wherein X is an aromatic group, n is an integer of from 1-3 per aromatic nucleus, R is an aliphatic group of from 5-16 carbon atoms exclusive of branching and R' is halogen or the residue of an alcohol, amine r carboxylic acid used to form an ester, amide or anhydride of the carboxylic acid.
Claim 12
Dependent Claim
11 words
A process according to claim 9 wherein the compound is iophendylate.
Claim 13
Dependent Claim
33 words
A process according to claims 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 wherein the contrast agent is comprised of up to about 45% by volume of the iodinated compound.
Claim 14
Dependent Claim
13 words
A process according to claim 11 wherein the contrast agent is administered orally.
Claim 15
Dependent Claim
13 words
A process according to claim 11 wherein the contrast agent is administered rectally.
References Cited (Backward Citations)
US2348231A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-11-01 | 1997-05-03 | 1997-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-11-01 | 2001-05-03 | 2001-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-11-01 | 2005-05-03 | 2005-11-02 | $7700.00 | Window Closed / Lapsed |