US5250722A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Taxane derivatives, their preparation and use in oncology
Assignee: Indena SpA
•
Filing: 1992-05-11
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Granted: 1993-10-05
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Expires: 2012-05-11
Abstract
Abstract The preparation of new 3,11-cyclotaxanes having the general formula 1. Cyclotaxane 1a (1, R'═R"═H) may be isolated from plants of the genus Taxus. New cyclotaxanes 1 have antiblastic activity.
Inventors
- 👤 Ezio Bombardelli
- 👤 Bruno Gabetta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 01:45
CPC Classifications
C; C07; C07C; C07C49/00; C07C69/00; C07C69/612; C07C69/618; A; A61; A61P; A61P35/00; C07C2603/00; C07C2603/56; C07C2603/58; C07C2603/76; C07C2603/80; C07C2603/86
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
26 words
A compound of the formula: ##STR3## wherein each of R' and R" independently of the other is hydrogen, alkanoyl of 2 to 7 carbon atoms, ##STR4##
Claim 2
Dependent Claim
26 words
A compound of the formula: ##STR3## wherein each of R' and R" independently of the other is hydrogen, alkanoyl of 2 to 7 carbon atoms, ##STR4##
Claim 3
Dependent Claim
14 words
A compound according to claim 1 wherein each of R' and R" is hydrogen.
Claim 4
Dependent Claim
14 words
A compound according to claim 1 wherein R' is hydrogen and R" is acetyl.
Claim 5
Dependent Claim
27 words
The method of producing an antimitotic effect in a mammal in need thereof which comprises administering thereto an effective amount of a compound according to claim 1.
Claim 6
Dependent Claim
27 words
The method of producing an antimitotic effect in a mammal in need thereof which comprises administering thereto an effective amount of the compound according to claim 2.
Claim 7
Dependent Claim
27 words
The method of producing an antimitotic effect in a mammal in need thereof which comprises administering thereto an effective amount of the compound according to claim 3.
Claim 8
Dependent Claim
23 words
A pharmaceutical composition which comprises an antimitotically effective amount of the compound according to claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
23 words
A pharmaceutical composition which comprises an antimitotically effective amount of the compound according to claim 2 in combination with a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
23 words
A pharmaceutical composition which comprises an antimitotically effective amount of the compound according to claim 3 in combination with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
46 words
In the process for the preparation of a compound according to claim 1, the steps which comprise irradiating an ethanolic solution of a compound of the formula: ##STR5## At 240 nm and treating the reaction mixture with tetrahydrofuran at reflux temperature in the presence of diphenylsulfide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-10-04 | 1997-04-05 | 1997-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-10-04 | 2001-04-05 | 2001-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-10-04 | 2005-04-05 | 2005-10-05 | $7700.00 | Window Closed / Lapsed |