US5250672A
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Contrast agent for NMR imaging
Assignee: Guerbet SA
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Filing: 1986-09-11
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Granted: 1993-10-05
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Expires: 2006-09-11
Abstract
Abstract A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H 2 O relaxation times in NMR diagnosis may comprise a polysaccharide to which is chemically linked both an NSL compound and an organic complexing agent to which is complexed a paramagnetic metal ion, such as Gd(III) or Cu(II). Polysaccharides include dextran, starch and cellulose. The preferred NSL compound is 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl.
Inventors
- 👤 Peter J. Sadler
- 👤 Charles T. Harding
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:58
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/20; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
84 words
An NMR diagnostic agent comprising a polysaccharide selected from the group consisting of dextran, dextrin, cellulose, Sepharose and starch, to which are chemically linked by a cyanogen bromide linkage both a nitroxyl spin label compound and an organic complexant consisting of an aminopolyacetic acid to which is complexed a paramagnetic metal ion having an atomic number selected from the group consisting of 58 to 70, 42, 44 and 21 to 29, wherein the organic complexant forms a chelate with the said paramagnetic metal ion.
Claim 2
Dependent Claim
84 words
An NMR diagnostic agent comprising a polysaccharide selected from the group consisting of dextran, dextrin, cellulose, Sepharose and starch, to which are chemically linked by a cyanogen bromide linkage both a nitroxyl spin label compound and an organic complexant consisting of an aminopolyacetic acid to which is complexed a paramagnetic metal ion having an atomic number selected from the group consisting of 58 to 70, 42, 44 and 21 to 29, wherein the organic complexant forms a chelate with the said paramagnetic metal ion.
Claim 3
Dependent Claim
16 words
The agent as claimed in claim 1 wherein the nitroxyl spin label compound is 4-amino-2, 2,6,6-tetramethylpiperidine-1-oxyl.
Claim 4
Dependent Claim
15 words
The agent as claimed in claim 1, wherein the organic complexant is diethylenetriamine pentaacetic acid.
Claim 5
Dependent Claim
15 words
The agent as claimed in claim 1, wherein the paramagnetic metal ion is gadolinium (III).
Claim 6
Dependent Claim
15 words
The agent as claimed in claim 1, wherein the paramagnetic metal ion is copper (II).
Claim 7
Dependent Claim
35 words
The agent as claimed in claim 1 wherein the aminopolyacetic acid is selected from the group consisting of nitrilotriacetic acid, N,N,N',N'-ethylene diamine-tetraacetic acid, N-hydroxyethyl-N,N',N'-ethylene diamine triacetic acid, N,N,N',N",N"-diethylene triamine pentaacetic acid and N-hydroxyethylimino diacetic acid.
Claim 8
Dependent Claim
84 words
An NMR diagnostic agent comprising a polysaccharide selected from the group consisting of dextran, dextrin, starch, cellulose and sepharose to which is chemically linked by a cyanogen bromide linkage both a nitroxyl spin label compound and an organic complexant consisting of an aminopolyacetic acid to which is complexed a paramagnetic metal ion having an atomic number selected from the group consisting of 58 to 70, 42, 44 and 21 to 29, wherein the organic complexant forms a chelate with the said paramagnetic metal ion.
Claim 9
Dependent Claim
84 words
An NMR diagnostic agent comprising a polysaccharide selected from the group consisting of dextran, dextrin, starch, cellulose and sepharose to which is chemically linked by a cyanogen bromide linkage both a nitroxyl spin label compound and an organic complexant consisting of an aminopolyacetic acid to which is complexed a paramagnetic metal ion having an atomic number selected from the group consisting of 58 to 70, 42, 44 and 21 to 29, wherein the organic complexant forms a chelate with the said paramagnetic metal ion.
Claim 10
Dependent Claim
95 words
An NMR diagnostic agent comprising a polysaccharide selected from the group consisting of dextran, dextrin, starch, cellulose and sepharose to which is chemically linked by a cyanogen bromide linkage both a nitroxyl spin label compound and an organic complexant consisting of an aminopolyacetic acid selected from the group consisting of nitrilotriacetic acid, N,N,N',N'-ethylene diamine tetraacetic acid, N-hydroxyethyl-N,N',N'-ethylene diamine triacetic acid, N,N,N',N",N"-diethylene triamine pentaacetic acid and N-hydroxy-ethylimino diacetic acid to which is complexed a paramagnetic metal ion having an atomic number selected from the group consisting of 58 to 70, 42, 44 and 21 to 29.
Claim 11
Dependent Claim
95 words
An NMR diagnostic agent comprising a polysaccharide selected from the group consisting of dextran, dextrin, starch, cellulose and sepharose to which is chemically linked by a cyanogen bromide linkage both a nitroxyl spin label compound and an organic complexant consisting of an aminopolyacetic acid selected from the group consisting of nitrilotriacetic acid, N,N,N',N'-ethylene diamine tetraacetic acid, N-hydroxyethyl-N,N',N'-ethylene diamine triacetic acid, N,N,N',N",N"-diethylene triamine pentaacetic acid and N-hydroxy-ethylimino diacetic acid to which is complexed a paramagnetic metal ion having an atomic number selected from the group consisting of 58 to 70, 42, 44 and 21 to 29.
Claim 12
Dependent Claim
36 words
An NMR diagnostic agent consisting of starch to which is chemically linked by a cyanogen bromide linkage a nitroxyl spin label compound consisting of 4-amino-2,2,6,6,-tetramethylpiperidine-1-oxyl and diethylene triamine pentaacetic acid to which is complexed gadolinium (III).
Claim 13
Dependent Claim
36 words
An NMR diagnostic agent consisting of starch to which is chemically linked by a cyanogen bromide linkage a nitroxyl spin label compound consisting of 4-amino-2,2,6,6,-tetramethylpiperidine-1-oxyl and diethylene triamine pentaacetic acid to which is complexed gadolinium (III).
Claim 14
Dependent Claim
37 words
An NMR diagnostic agent consisting of cellulose to which is chemically linked by a cyanogen bromide linkage a nitroxyl spin label compound consisting of 4-amino-2,2,6,6, -tetramethylpiperidine-1-oxyl and diethylene triamine pentaacetic acid to which is complexed copper (II).
Claim 15
Dependent Claim
37 words
An NMR diagnostic agent consisting of cellulose to which is chemically linked by a cyanogen bromide linkage a nitroxyl spin label compound consisting of 4-amino-2,2,6,6, -tetramethylpiperidine-1-oxyl and diethylene triamine pentaacetic acid to which is complexed copper (II).
Claim 16
Dependent Claim
36 words
An NMR diagnostic agent consisting of starch to which is chemically linked by a cyanogen bromide linkage a nitroxyl spin label compound consisting of 4-amino-2,2,6,6,-tetramethylpiperidine-1-oxyl and diethylene triamine pentaacetic acid to which is complexed copper (II).
Claim 17
Dependent Claim
36 words
An NMR diagnostic agent consisting of starch to which is chemically linked by a cyanogen bromide linkage a nitroxyl spin label compound consisting of 4-amino-2,2,6,6,-tetramethylpiperidine-1-oxyl and diethylene triamine pentaacetic acid to which is complexed copper (II).
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-10-04 | 1997-04-05 | 1997-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-10-04 | 2001-04-05 | 2001-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-10-04 | 2005-04-05 | 2005-10-05 | $7700.00 | Window Closed / Lapsed |