US5250263A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus for processing or preparing liquid samples for chemical analysis
Assignee: Qiagen NV
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Filing: 1991-10-30
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Granted: 1993-10-05
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Expires: 2011-10-30
Abstract
Abstract An apparatus (1) for processing or preparing liquid samples for a preferably quantitative chemical analysis, especially for flow-injection analysis, is, for the purpose of miniaturisation and reducing the necessary sample volume while at the same time reducing the analysis time, assembled from a set of plate-like components (8). Each of the components (8) includes channels to form pipe pieces (9) and/or branches (13) with orifices and/or values, for example non-return valves, and/or pumps (6,7) in order to be able to feed the carrier liquid and sample to a detector (3) in the desired manner. Depending on the purpose of the analysis, the components (8) with the pipes and functional parts contained in them may be stacked in varying number and/or sequence and/or angular orientation relative to one another and can be connected in a sealing manner in the operative position.
Inventors
- 👤 Andreas Manz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 22:41
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/08; B; B01; B01J; B01J19/00; B01J19/0093; B01J2219/00; B01J2219/00781; B01J2219/00783; B01J2219/00889; B01J2219/00891; G01N2035/00178; G01N2035/00326; Y; Y10; Y10T; Y10T436/00; Y10T436/11; Y10T436/117497; Y10T436/119163
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
252 words
An apparatus for processing or preparing liquid samples for chemical analysis, especially for flow injection analysis (FIA), comprising in combination a plurality of plate components, said plate components each being provided with a central throughhole and several additional throughholes that are distributed across the surface of each plate component, at least one of said components having a horizontally extending channel segment in the form of a groove that extends from said central throughhole towards the periphery of the respective plate component, said plate components being stackable in a predetermined order of arrangement one above the other such that said central throughhole and at least some of the throughholes distributed across each plate component are in alignment with respective throughholes of neighboring components, thus forming at least one interconnected fluid channel system, which extends vertically through the stacked components and includes said horizontally extending channel segment provided in said at least one of said plate components, the channel system being adapted for transportation of a fluid through the stacked plate components; and further comprising at least one integrally formed diaphragm pump, consisting essentially of two of said neighboring plate components which enclose a diaphragm arranged between them, and activation means for deflecting the diaphragm vertically between a first and second position such that the diaphragm pump sucks or pumps fluid through respective throughholes which are provided in one of said two neighboring plate components located next to one side of said diaphragm, and which communicate with said at least one fluid channel system.
Claim 2
Independent Claim
252 words
An apparatus for processing or preparing liquid samples for chemical analysis, especially for flow injection analysis (FIA), comprising in combination a plurality of plate components, said plate components each being provided with a central throughhole and several additional throughholes that are distributed across the surface of each plate component, at least one of said components having a horizontally extending channel segment in the form of a groove that extends from said central throughhole towards the periphery of the respective plate component, said plate components being stackable in a predetermined order of arrangement one above the other such that said central throughhole and at least some of the throughholes distributed across each plate component are in alignment with respective throughholes of neighboring components, thus forming at least one interconnected fluid channel system, which extends vertically through the stacked components and includes said horizontally extending channel segment provided in said at least one of said plate components, the channel system being adapted for transportation of a fluid through the stacked plate components; and further comprising at least one integrally formed diaphragm pump, consisting essentially of two of said neighboring plate components which enclose a diaphragm arranged between them, and activation means for deflecting the diaphragm vertically between a first and second position such that the diaphragm pump sucks or pumps fluid through respective throughholes which are provided in one of said two neighboring plate components located next to one side of said diaphragm, and which communicate with said at least one fluid channel system.
Claim 3
Dependent Claim
61 words
An apparatus according to claim 1, wherein the throughholes which are provided in said plate component next to one side of said diaphragm and through which said fluid is sucked or pumped are shaped as valves, said throughholes being funnel-shaped across the thickness of said component, and containing a vertically displaceable spherical valve member in a tapered region of said throughholes.
Claim 4
Dependent Claim
34 words
An apparatus according to claim 2, wherein assemblies of varying numbers of said plate components are stackable in varying sequences and orientations, each different assembly of said plate components defining a different channel system.
Claim 5
Dependent Claim
55 words
An apparatus according to claim 3, wherein in each channel system, there are provided a number of valves, each valve being defined by a throughhole in a respective plate component, said throughhole being funnel-shaped across the thickness of said component and containing a vertically displaceable spherical valve member in a tapered region of said throughhole.
Claim 6
Dependent Claim
53 words
An apparatus according to claim 1, wherein said plate components further comprise centering or connecting holes which are provided at their periphery such that, irrespective of an angular orientation of said plate components with respect to each other in a stacked combination said centering or connecting holes are in alignment with each other.
Claim 7
Dependent Claim
41 words
An apparatus according to claim 5, wherein said plate components have identical outer contours and are of equal size, such that when the components are stacked and the centering or connecting holes are in alignment, the circumferences of the components align.
Claim 8
Dependent Claim
18 words
An apparatus according to claim 6, wherein the outer contours of said plate components are circular or square.
Claim 9
Dependent Claim
42 words
An apparatus according to claim 1, wherein neighboring plate components have mutually opposing surfaces which have parallel planes such that upon assembly, said neighboring plate components engage sealingly so that no fluid can exit at the interface between said mutually opposing surfaces.
Claim 10
Dependent Claim
31 words
An apparatus according to claim 5, further comprising threaded rods or screws which extend through said centering or connecting holes for pressing said stacked plate components together in a sealing manner.
Claim 11
Dependent Claim
76 words
An apparatus according to claim 9, wherein said stacked plate components are arranged between two cover-plates, said cover plates having meeting surfaces which have parallel planes respective to the top-most and lower-most faces of the outer plate components of the stack, said cover-plates being provided with openings which communicate with said channel system, said openings being shaped to accommodate entry and exit lines for a sample, and including reflective surfaces for forming an optical detector cell.
Claim 12
Dependent Claim
21 words
An apparatus according to claim 1, wherein said activation means consists of electrical or hydraulic drive means for deflecting said diaphragm.
Claim 13
Dependent Claim
22 words
An apparatus according to claim 1, wherein said plate components are of miniaturized size and are made of glass, plastic, or metal.
Claim 14
Dependent Claim
24 words
An apparatus according to claim 1, wherein said plate components are of a size comparable to electronic chips, and are made of monocrystalline material.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-10-04 | 1997-04-05 | 1997-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-10-04 | 2001-04-05 | 2001-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-10-04 | 2005-04-05 | 2005-10-05 | $7700.00 | Window Closed / Lapsed |