US5246967A
Expired / Lapsed
US
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Use of esters of acyl l-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the treatment of hepatopathies
Assignee: Sigma Tau Industrie Farmaceutiche Riunite SpA
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Filing: 1992-05-15
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Granted: 1993-09-21
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Expires: 2012-05-15
Abstract
Abstract Esters of acyl L-carnitine with gamma-hydroxybutyric acid, both as pharmacologically acceptable salts of formula (1) ##STR1## and as inner salts of formula (1') ##STR2## wherein X - is the anion of a pharmacologically acceptable acid and R is a straight or branched acyl group having from 2 to 5 carbon atoms, are used for producing pharmaceutical compositions effective for treating hepatopathies.
Inventors
- 👤 Fabio Zezza
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/185; A61K31/205; A61P; A61P1/00; A61P1/16
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
36 words
A process for treating a hepatopathy in a patient in need of such treatment which comprises orally or parenterally administering to the patient a therapeutically effective amount of an ester of acyl L-carnitine with gamma-hydroxybutyric acid.
Claim 2
Dependent Claim
36 words
A process for treating a hepatopathy in a patient in need of such treatment which comprises orally or parenterally administering to the patient a therapeutically effective amount of an ester of acyl L-carnitine with gamma-hydroxybutyric acid.
Claim 3
Dependent Claim
12 words
A process according to claim 1, wherein the hepatopathy is viral hepatitis.
Claim 4
Dependent Claim
49 words
A process according to claim 2, wherein the ester is in the form of a pharmacologically acceptable salt of formula (1) ##STR21## wherein X - is the anion of a pharmacologically acceptable acid and R is a straight or branched acyl group having for 2 to 5 carbon atoms.
Claim 5
Dependent Claim
35 words
A process according to claim 2, wherein the ester is in the form of an inner salt (1') ##STR22## wherein R is a straight or branched acyl group having from 2 to 5 carbon atoms.
Claim 6
Dependent Claim
49 words
A process according to claim 1, wherein the ester is in the form of a pharmacologically acceptable salt of formula (1) ##STR23## wherein X - is the anion of a pharmacologically acceptable acid and R is a straight or branched acyl group having from 2 to 5 carbon atoms.
Claim 7
Dependent Claim
35 words
A process according to claim 1, wherein the ester is in the form of an inner salt (1') ##STR24## wherein R is a straight or branched acyl group having from 2 to 5 carbon atoms.
Claim 8
Dependent Claim
19 words
A process according to claim 6, wherein the ester is an acetyl, propionyl, n-butyryl, isobutyryl or isovaleryl L-carnitine gamma-hydroxybutyrate.
Claim 9
Dependent Claim
19 words
A process according to claim 5, wherein the ester is an acetyl, propionyl, n-butyryl, isobutyryl or isovaleryl L-carnitine gamma-hydroxybutyrate.
Claim 10
Dependent Claim
38 words
A process according to claim 5, wherein X - is an anion selected from the group consisting of chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate.
References Cited (Backward Citations)
EP0442850A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-20 | 1997-03-22 | 1997-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-20 | 2001-03-22 | 2001-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-20 | 2005-03-22 | 2005-09-21 | $7700.00 | Window Closed / Lapsed |