US5244922A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for treating viral infections
Assignee: Individual
•
Filing: 1992-05-27
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Granted: 1993-09-14
•
Expires: 2012-05-27
Abstract
Abstract The present invention provides methods for treating viral diseases in humans by administering to an afflicted host pharmaceutical compositions containing a therapeutically effective amount of a combination of ##STR1## in a weight ratio ranging from about 1:1 to about 1:10 (A:B); wherein R is OH, NH 2 , OW, or H; X is H, F, Cl, Br, I, OH, OW, NO 2 , or NH 2 ; Y is H, F, Cl, Br, or I; W is ##STR2## or a C 1 to C 12 aliphatic group; Z is an aliphatic or aromatic group of C 1 to C 12 ; X and Y can both vary within the compound; or pharmaceutically acceptable salts thereof. Particularly disclosed herein is a composition comprising a 1 to 4 ratio of the sodium salts of phenylacetylglutamine and phenylacetic acid, formulated in both oral and parenteral forms clinically useful in the treatment of herpes virus, HIV, human papilloma virus, rhinovirus, coronavirus, orthomyxovirus and paramyxovirus.
Inventors
- 👤 Stanislaw R. Burzynski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 12:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445; A61K45/00; A61K45/06
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
121 words
A method of treating disease producing viral infections in an afflicted human host comprising: administering to the host a pharmaceutical composition containing a therapeutically effective amount of a combination of compounds of the formula: ##STR5## in a weight ratio ranging from about 1:1 to about 1:10 (A:B); wherein R is OH, NH 2 , OW, or H; X is H, F, Cl, Br, I, OH, OW, NO 2 , or NH 2 ; Y is H, F, Cl, Br, or I; W is ##STR6## or a C 1 to C 12 aliphatic group; Z is an aliphatic or aromatic group pf C 1 to C 12 ; X and Y can both vary within the compound; or pharmaceutically acceptable salts thereof.
Claim 2
Independent Claim
121 words
A method of treating disease producing viral infections in an afflicted human host comprising: administering to the host a pharmaceutical composition containing a therapeutically effective amount of a combination of compounds of the formula: ##STR5## in a weight ratio ranging from about 1:1 to about 1:10 (A:B); wherein R is OH, NH 2 , OW, or H; X is H, F, Cl, Br, I, OH, OW, NO 2 , or NH 2 ; Y is H, F, Cl, Br, or I; W is ##STR6## or a C 1 to C 12 aliphatic group; Z is an aliphatic or aromatic group pf C 1 to C 12 ; X and Y can both vary within the compound; or pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
22 words
The method of claim 1 wherein the pharmaceutical composition contains a mixture of phenylacetylglutamine and phenylacetic acid or pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein the pharmaceutical composition contains a 1:4 ratio of A:B.
Claim 5
Dependent Claim
22 words
The method of claim 2 wherein the pharmaceutical composition contains a 1:4 ratio of phenylacetylglutamine sodium salt and phenylacetic acid sodium salt.
Claim 6
Dependent Claim
21 words
The method of claim 1 wherein the pharmaceutical composition is administered to humans in the amount of 0.5 to 60 g/day.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein the pharmaceutical composition is administered orally, topically or parenterally.
Claim 8
Dependent Claim
14 words
The method of claim 1 wherein the afflicted host is infected with herpes viruses.
Claim 9
Dependent Claim
13 words
The method of claim 1 wherein the afflicted host is infected with lentiviruses.
Claim 10
Dependent Claim
13 words
The method of claim 1 wherein the afflicted host is infected with adenoviruses.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein the afflicted host is infected with papovaviruses.
Claim 12
Dependent Claim
13 words
The method of claim 1 wherein the afflicted host is infected with rhinoviruses.
Claim 13
Dependent Claim
13 words
The method of claim 1 wherein the afflicted host is infected with coronaviruses.
Claim 14
Dependent Claim
13 words
The method of claim 1 wherein the afflicted host is infected with orthomyxoviruses.
Claim 15
Dependent Claim
13 words
The method of claim 1 wherein the afflicted host is infected with paramyxoviruses.
Claim 16
Dependent Claim
13 words
The method of claim 1 wherein the afflicted host is infected with retroviruses.
Claim 17
Dependent Claim
15 words
The method of claim 1 wherein the afflicted host is infected with human papilloma viruses.
Claim 18
Dependent Claim
14 words
The method of claim 1 wherein the afflicted host is infected with tumorogenic viruses.
Claim 19
Dependent Claim
12 words
The method of claim 1 wherein the pharmaceutical composition is administered systemically.
Claim 20
Dependent Claim
18 words
The method of claim 18 wherein the pharmaceutical composition is administered orally, parenterally, intravenously, intradermally, subcutaneously, or intraperitoneally.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-13 | 1997-03-15 | 1997-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-13 | 2001-03-15 | 2001-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-13 | 2005-03-15 | 2005-09-14 | $7700.00 | Window Closed / Lapsed |