US5241012A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Activated and conjugated polystyrene substrate
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1987-05-19
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Granted: 1993-08-31
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Expires: 2007-05-19
Abstract
Abstract Solid substrates and methods for their preparation are provided, where enhanced functionalization of solid substrates is achieved, so that higher levels of binding of a wide variety of moieties can be obtained. The surface is nitrated with a nitronium agent, where the nitro groups may be modified in a variety of ways to serve as sites for linking. The resulting solid substrates find use in therapy, diagnosis and processing.
Inventors
- 👤 Brian Clark
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:35
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/34; C08F8/30; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
94 words
An article comprising a functionalized polystyrene having at least about 25% of the styryl groups at the surface functionalized, prepared by a process comprising: contacting a surface of said polystyrene with an electrophilic substituting agent comprising a polyhalo complex anion as the counterion to said electrophilic substituting agent in tetramethylsulfone in the presence of from about 0.1 mol % to about 1 mol % based on said electrophilic substituting agent of an oxy polar compound to produce derivatization substantially exclusively on said surface; wherein said article is a container or a microtiter well plate.
Claim 2
Dependent Claim
94 words
An article comprising a functionalized polystyrene having at least about 25% of the styryl groups at the surface functionalized, prepared by a process comprising: contacting a surface of said polystyrene with an electrophilic substituting agent comprising a polyhalo complex anion as the counterion to said electrophilic substituting agent in tetramethylsulfone in the presence of from about 0.1 mol % to about 1 mol % based on said electrophilic substituting agent of an oxy polar compound to produce derivatization substantially exclusively on said surface; wherein said article is a container or a microtiter well plate.
Claim 3
Dependent Claim
19 words
An article according to claim 1, wherein said functionalized polystyrene is functionalized with at least partially reduced nitro groups.
Claim 4
Dependent Claim
15 words
An article according to claim 2, wherein said partially reduced nitro groups are amino groups.
Claim 5
Dependent Claim
19 words
An article according to claim 1 wherein said article is a molded article having a clear, relatively smooth surface.
Claim 6
Dependent Claim
19 words
An article according to claim 1 wherein said article is an extruded article having a clear, relatively smooth surface.
References Cited (Backward Citations)
US2592349A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-30 | 1997-03-01 | 1997-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-30 | 2001-03-01 | 2001-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-30 | 2005-03-01 | 2005-08-31 | $7700.00 | Window Closed / Lapsed |