US5240909A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of lactoferrin for treatment of toxic effects of endotoxins
Assignee: Individual
•
Filing: 1991-03-13
•
Granted: 1993-08-31
•
Expires: 2011-03-13
Abstract
Abstract Animal species are treated either intravenously or by tube directly to the gut with a solution containing a lactoferrin bound to a metal ion, the metal ion content being at least 0.1 mg per gram of lactoferrin. The dose is sufficient to inhibit endotoxins.
Inventors
- 👤 Dietrich Nitsche
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:37
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/40; A61K38/19; A61K38/193; A61K39/00; A61K39/395
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
31 words
A method of protecting animal species from the toxic effects of endotoxins comprising administering to an animal an endotoxin reducing dose of a solution containing lactoferrin bound to a metal ion.
Claim 2
Independent Claim
31 words
A method of protecting animal species from the toxic effects of endotoxins comprising administering to an animal an endotoxin reducing dose of a solution containing lactoferrin bound to a metal ion.
Claim 3
Dependent Claim
24 words
A method according to claim 1 wherein the metal ion is selected from the group consisting of iron, zinc, copper, cobalt, manganese and magnesium.
Claim 4
Dependent Claim
12 words
A method according to claim 2 wherein the metal ion is iron.
Claim 5
Dependent Claim
19 words
A method according to claim 3 wherein the iron content is at least 0.1 ug per gram of lactoferrin.
Claim 6
Dependent Claim
19 words
A method according to claim 4 wherein the iron content is at least 100 ug per gram of lactoferrin.
Claim 7
Dependent Claim
15 words
A method according to claim 1 wherein the lactoferrin is combined with an immunoglobulin solution.
Claim 8
Dependent Claim
12 words
A method according to claim 5 wherein the immunoglobulin solution contains IgG.
Claim 9
Dependent Claim
15 words
A method according to claim 6 wherein the immunoglobulin solution contains IgG, IgM and IgA.
Claim 10
Dependent Claim
14 words
A method according to claim 3 wherein the solution contains a colony stimulating factor.
Claim 11
Independent Claim
32 words
A method of protecting animal species from the toxic effects of endotoxins comprising administering intravenously to an animal an endotoxin reducing dose of a solution containing lactoferrin bound to a metal ion.
Claim 12
Independent Claim
32 words
A method of protecting animal species from the toxic effects of endotoxins comprising administering intravenously to an animal an endotoxin reducing dose of a solution containing lactoferrin bound to a metal ion.
Claim 13
Dependent Claim
24 words
A method according to claim 10 wherein the metal ion is selected from the group consisting of iron, zinc, copper, cobalt, manganese and magnesium.
Claim 14
Dependent Claim
12 words
A method according to claim 11 wherein the metal ion is iron.
Claim 15
Dependent Claim
18 words
A method according to claim 12 wherein the iron content is at least 0.1 per gram of lactoferrin.
Claim 16
Independent Claim
37 words
A method of protecting animal species from the toxic effects of endotoxins comprising administering by a tube to the gut of an animal an endotoxin reducing dose of a solution containing lactoferrin bound to a metal ion.
Claim 17
Independent Claim
37 words
A method of protecting animal species from the toxic effects of endotoxins comprising administering by a tube to the gut of an animal an endotoxin reducing dose of a solution containing lactoferrin bound to a metal ion.
Claim 18
Dependent Claim
24 words
A method according to claim 14 wherein the metal ion is selected from the group consisting of iron, zinc, copper, cobalt, manganese and magnesium.
Claim 19
Dependent Claim
12 words
A method according to claim 15 wherein the metal ion is iron.
Claim 20
Dependent Claim
19 words
A method according to claim 16 wherein the iron content is at least 0.1 ug per gram of lactoferrin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-30 | 1997-03-01 | 1997-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-30 | 2001-03-01 | 2001-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-30 | 2005-03-01 | 2005-08-31 | $7700.00 | Window Closed / Lapsed |