US5236956A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compounds for the treatment of urinary incontinence
Assignee: Pfizer Health AB
•
Filing: 1991-10-07
•
Granted: 1993-08-17
•
Expires: 2011-10-07
Abstract
Abstract The invention concerns compounds having the formula I ##STR1## wherein Ar is a phenyl or benzyl group which is optionally substituted with hydroxy or alkoxy; R 1 is hydrogen, lower alkyl, lower alkoxy, hydroxy; R 2 is hydrogen, lower alkyl; R 3 is NR 4 R 5 , wherein R 4 and R 5 which can be the same or different, are lower alkyl, or wherein R 4 and R 5 , when taken together, form a ring with the nitrogen atom, whereby said ring optionally is substituted with lower alkyl; n is 0 or 1; m is 2 or 3 and their salts with physiologically acceptable acids and when the compounds can be in form of optical isomers, the racemic mixture and the individual isomers, for the treatment of disorders of the urinary bladder.
Inventors
- 👤 Christer Sjogren
- 👤 Rene Mollberg
- 👤 Sten Kelfve
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:34
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/12; C07D295/125; C07D295/13; A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445; C07C; C07C233/00; C07C233/01; C07C233/34; C07C233/35; C07C233/40; C07C235/00; C07C235/02; C07C235/32; C07C235/34
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
102 words
Compounds having the general formula II: ##STR4## wherein Ar is a phenyl group which is optionally substituted with hydroxy; R 1 is hydrogen or lower alkyl; R 2 is hydrogen or lower alkyl; R 7 and R 8 which can be the same or different, are lower alkyl, wherein one or both of R 7 and R 8 is branched and the total number of carbon atoms in R 7 and R 8 is at least 6; their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers.
Claim 2
Dependent Claim
102 words
Compounds having the general formula II: ##STR4## wherein Ar is a phenyl group which is optionally substituted with hydroxy; R 1 is hydrogen or lower alkyl; R 2 is hydrogen or lower alkyl; R 7 and R 8 which can be the same or different, are lower alkyl, wherein one or both of R 7 and R 8 is branched and the total number of carbon atoms in R 7 and R 8 is at least 6; their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers.
Claim 3
Dependent Claim
15 words
Compounds according to claim 1 characterized in that R 7 and R 8 are isopropyl.
Claim 4
Dependent Claim
14 words
The compounds of claim 1, selected from the group consisting of: N-methyl-N-(2-diisopropylaminoethyl)-2,2-diphenylacetamide N-(2-diisopropylaminoethyl)-2,2-diphenylacetamide N-methyl-N-(2-diisopropylaminoethyl)-2-methyl-2,2-diphenylacetamide.
Claim 5
Dependent Claim
15 words
A pharmaceutical composition comprising a compound according to claim 1 with a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
15 words
A pharmaceutical composition comprising a compound according to claim 2 with a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
15 words
A pharmaceutical composition comprising a compound according to claim 3 with a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
US2009144A
Cited
US2733256A
Cited
US2658076A
Cited
US2746992A
Cited
US2831892A
Cited
US2862965A
Cited
US2932645A
Cited
US3808213A
Cited
FR2319337A1
Cited
FR2333501A2
Cited
GB1560839A
Cited
FR2340724A2
Cited
GB1574046A
Cited
FR2421892A1
Cited
FR2421891A1
Cited
EP0364123A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-16 | 1997-02-15 | 1997-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-16 | 2001-02-15 | 2001-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-16 | 2005-02-15 | 2005-08-17 | $7700.00 | Window Closed / Lapsed |