US5235028A
Expired / Lapsed
US
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Polyethylene glycol derivatives for solid-phase applications
Assignee: University of Minnesota Twin Cities
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Filing: 1991-09-16
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Granted: 1993-08-10
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Expires: 2011-09-16
Abstract
Abstract The present invention pertains to polyethylene glycol (PEG) derivatized graft supports, to methods for making these supports and to methods of using the supports to synthesize peptides by solid-phase synthesis techniques. The PEG-graft supports of this invention comprise functionalized PEG derivatives which are covalently attached to solid supports, such as polystyrene.
Inventors
- 👤 George Barany
- 👤 Fernando Albericio
- 👤 Jane Chang
- 👤 Samuel Zalipsky
- 👤 Nuria A. Sole
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 06:55
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/04; C07K1/042; C08; C08F; C08F8/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
105 words
A resin for solid-phase synthesis having the formula: ##STR8## wherein n is an integer from about 5 to about 150; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of H, alkyl groups and aryl groups; X is H or H 2 N--B--NH--C(O)--A--C(O)--; A and B are independently selected from the group consisting of straight chain or branched alkyl groups having up to about 10 carbon atoms, CH═CH groups and aromatic groups; and SS is a solid support, wherein the amino group is optionally protected by an N.sup.ω protecting group.
Claim 2
Dependent Claim
105 words
A resin for solid-phase synthesis having the formula: ##STR8## wherein n is an integer from about 5 to about 150; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of H, alkyl groups and aryl groups; X is H or H 2 N--B--NH--C(O)--A--C(O)--; A and B are independently selected from the group consisting of straight chain or branched alkyl groups having up to about 10 carbon atoms, CH═CH groups and aromatic groups; and SS is a solid support, wherein the amino group is optionally protected by an N.sup.ω protecting group.
Claim 3
Dependent Claim
31 words
A resin of claim 1, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently H, methyl groups or ethyl groups.
Claim 4
Dependent Claim
20 words
A resin of claim 1, wherein A is selected from the group consisting of ethylene, propylene, isopropylene, butylene and isobutylene.
Claim 5
Dependent Claim
26 words
A resin of claim 1, wherein the solid support is selected from the group consisting of amino-functional membranes, porous glass, silica, polystyrenes, polydimethylacrylamides, cotton and paper.
Claim 6
Dependent Claim
23 words
A resin of claim 4, wherein the polystyrene is selected from the group consisting of amino-polystyrene, aminomethyl polystyrene, aminoacyl polystyrene and p-methylbenzhydrylamine polystyrene.
References Cited (Backward Citations)
DE3500180A1
Cited
EP0187391A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-09 | 1997-02-08 | 1997-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-09 | 2001-02-08 | 2001-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-09 | 2005-02-08 | 2005-08-10 | $7700.00 | Window Closed / Lapsed |