US5233036A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Rapamycin alkoxyesters
Assignee: Wyeth LLC
•
Filing: 1992-02-20
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Granted: 1993-08-03
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Expires: 2012-02-20
Abstract
Abstract A compound of the structure ##STR1## wherein R 1 is ##STR2## R 2 is hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms which is optionally unsaturated, aralkyl of 7-10 carbon atoms, or phenyl which is optionally mono-, di-, or tri-substituted with a substituent selected from alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, hydroxy, cyano, halo, nitro, carbalkoxy of 2-7 carbon atoms, trifluoromethyl, amino, or a carboxylic acid; or a pharmaceutically acceptable salt thereof when R 2 is hydrogen, which are useful in the treatment of transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, or fungal infections.
Inventors
- 👤 Philip F. Hughes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 14:41
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/12; C07D498/18; C07H; C07H19/00; C07H19/01
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
84 words
A compound of the structure ##STR6## wherein R 1 is ##STR7## R 2 is hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms which is optionally unsaturated phenylalkyl of 7-10 carbon atoms, or phenyl which is optionally mono-, di-, or tri-substituted with a substituent selected from alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, hydroxy, cyano, halo, nitro, carbalkoxy of 2-7 carbon atoms, trifluoromethyl, amino, or a carboxylic acid; or a pharmaceutically acceptable salt thereof when R 2 is hydrogen.
Claim 2
Dependent Claim
84 words
A compound of the structure ##STR6## wherein R 1 is ##STR7## R 2 is hydrogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms which is optionally unsaturated phenylalkyl of 7-10 carbon atoms, or phenyl which is optionally mono-, di-, or tri-substituted with a substituent selected from alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, hydroxy, cyano, halo, nitro, carbalkoxy of 2-7 carbon atoms, trifluoromethyl, amino, or a carboxylic acid; or a pharmaceutically acceptable salt thereof when R 2 is hydrogen.
Claim 3
Dependent Claim
14 words
A compound of claim 1 where R 2 is alkyl of 1-6 carbon atoms.
Claim 4
Dependent Claim
8 words
A compound of claim 1 which is 42-deoxy-42-(2-ethoxy-2-oxoethoxy)rapamycin.
Claim 5
Dependent Claim
8 words
A compound of claim 1 which is 42-deoxy-42-[2-(1,1-dimethylethoxy)-2-oxoethoxy]-rapamycin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-02 | 1997-02-01 | 1997-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-02 | 2001-02-01 | 2001-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-02 | 2005-02-01 | 2005-08-03 | $7700.00 | Window Closed / Lapsed |