Patent US6540542B1 successfully refreshed from Google Patents.
US5229490A
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Multiple antigen peptide system
Assignee: Rockefeller University
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Filing: 1990-12-20
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Granted: 1993-07-20
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Expires: 2010-12-20
Abstract
Abstract Multiple antigen peptide systems are described in which a large number of antigens are bound to the functional groups of a dendritic core molecule providing a high concentration of antigen in a low molecular volume. The products are useful for producing chemically defined univalent or multivalent vaccines and in diagnostic tests.
Inventors
- 👤 James P. Tam
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 22:44
CPC Classifications
C; C08; C08G; C08G83/00; C08G83/002; C08G83/003; C07; C07K; C07K14/00; C07K14/001; C07K14/005; C07K14/435; C07K14/44; C07K14/445; C07K14/705; C07K14/70503; C07K14/7051; C12; C12N; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10122; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/22; Y10S930/221; Y10S977/00; Y10S977/70; Y10S977/754
Claims Analysis
Total Claims: 54
Claim 1
Independent Claim
25 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which a plurality of antigenic molecules are joined by covalent bonds.
Claim 2
Dependent Claim
25 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which a plurality of antigenic molecules are joined by covalent bonds.
Claim 3
Dependent Claim
46 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups which are covalently bonded to antigenic molecules.
Claim 4
Dependent Claim
46 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups which are covalently bonded to antigenic molecules.
Claim 5
Dependent Claim
12 words
The antigenic product of claim 1 wherein the core molecule is lysine.
Claim 6
Dependent Claim
15 words
The antigenic product of claims 1, 2 or 3 wherein the antigenic molecules are identical.
Claim 7
Dependent Claim
15 words
The antigenic product of claims 1, 2 or 3 wherein the antigenic molecules are different.
Claim 8
Dependent Claim
21 words
The antigenic product of claims 1, 2 or 3 wherein the antigenic molecules are a combination of T-cell and B-cell antigens.
Claim 9
Dependent Claim
7 words
(Phe-Glu-Pro-Ser-Glu-Ala-Glu-Ile-Ser-His-Thr-Gln-Lys-Ala) 8 -Lys 4 -Lys 2 -Lys-Gly-OH.
Claim 10
Dependent Claim
7 words
(Phe-Glu-Pro-Ser-Glu-Ala-Glu-Ile-Ser-His-Thr-Gln-Lys-Ala) 8 -Lys 4 -Lys 2 -Lys-Gly-OH.
Claim 11
Dependent Claim
9 words
((Asn-Ala-Asn-Pro) 4 ) 8 Lys 4 -Lys 2 -Lys.
Claim 12
Dependent Claim
9 words
((Asn-Ala-Asn-Pro) 4 ) 8 Lys 4 -Lys 2 -Lys.
Claim 13
Dependent Claim
7 words
(Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Gln-Gly) 8 -Lys 4 -Lys 2 -Lys-Gly-OH.
Claim 14
Dependent Claim
7 words
(Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Gln-Gly) 8 -Lys 4 -Lys 2 -Lys-Gly-OH.
Claim 15
Dependent Claim
7 words
(Tyr-Ile-Gln-His-Lys-Leu-Gln-Gln-Glu-Ile-Arg-His-Ser-Pro) 8 -Lys 4 -Lys 3 -Lys-Gly-OH.
Claim 16
Dependent Claim
7 words
(Tyr-Ile-Gln-His-Lys-Leu-Gln-Gln-Glu-Ile-Arg-His-Ser-Pro) 8 -Lys 4 -Lys 3 -Lys-Gly-OH.
Claim 17
Dependent Claim
7 words
(Asp-Gly-Ile-Ser-Ala-Ala-Lys-Asp-Val) 8 -Lys 4 -Lys 2 -Lys-Gly-OH.
Claim 18
Dependent Claim
7 words
(Asp-Gly-Ile-Ser-Ala-Ala-Lys-Asp-Val) 8 -Lys 4 -Lys 2 -Lys-Gly-OH.
Claim 19
Dependent Claim
25 words
An antigenic product comprising a dendritic hompolymer containing up to 10 monomeric residues to which a malarial antigenic peptide is joined by a covalent bond.
Claim 20
Dependent Claim
25 words
An antigenic product comprising a dendritic hompolymer containing up to 10 monomeric residues to which a malarial antigenic peptide is joined by a covalent bond.
Claim 21
Dependent Claim
50 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which a malarial antigenic peptide is joined by covalent bonds.
Claim 22
Dependent Claim
50 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which a malarial antigenic peptide is joined by covalent bonds.
Claim 23
Dependent Claim
35 words
The antigenic product of claim 12 or 13 wherein the antigenic peptide is selected from the group consisting of: H-(ASN-Ala-ASN-Pro) n -OH wherein n is 3, H-(Gly-Asp-Arg-Ala-Asp-Gly-Gln-Pro-Ala) n -OH wherein n is 2, Glu-Gln-Asn-Val-Glu-His-Asp-Ala, Asn-Ala-Glu-Asn-Lys-Glu-Glu-Leu-Thr-Ser-Ser-Asp-Pro-Glu-Gly-Gln-Ile-Met.
Claim 24
Dependent Claim
25 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which an hepatitis antigenic peptide is joined by a covalent bond.
Claim 25
Dependent Claim
25 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which an hepatitis antigenic peptide is joined by a covalent bond.
Claim 26
Dependent Claim
51 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which an hepatitis antigenic peptide is joined by a covalent bond.
Claim 27
Dependent Claim
51 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which an hepatitis antigenic peptide is joined by a covalent bond.
Claim 28
Dependent Claim
23 words
The antigenic product of claim 15 or 16 wherein the antigenic peptide is selected from the group consisting of: Met-Gln-Trp-Asr-Ser-Thr-Ala-Phe-His-Gln-Thr-Leu-Gln-Asp-Pro-Arg-Val-Arg-Gly-Leu-Try-Leu-Tyr-Leu-Pro-Ala-Gly-Gly, Asp-Pro-Arg-Val-Arg-Gly-Leu-Tyr-Phe-Pro-Ala-Gly-Gly-Ser-Ser-Ser-Gly-Thr-Val and Cys-Thr-Lys-Pro-Thr-Asp-Gly-Asn-Cys-Thr-Cys.
Claim 29
Dependent Claim
25 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which a streptococcus antigenic peptide is joined by a covalent bond.
Claim 30
Dependent Claim
25 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which a streptococcus antigenic peptide is joined by a covalent bond.
Claim 31
Dependent Claim
51 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which a streptococcus antigenic peptide is joined by a covalent bond.
Claim 32
Dependent Claim
51 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which a streptococcus antigenic peptide is joined by a covalent bond.
Claim 33
Dependent Claim
14 words
The antigenic product of claim 18 or 19 wherein the antigenic peptide is: Asn-Phe-Ser-Thr-Ala-Asp-Ser-Ala-Lys-Ile-Lys-Thr-Leu-Glu-Ala-Glu-Lys-Ala-Asp-Leu-Gly-Lys-Ala-Leu-Gly-Ala.
Claim 34
Dependent Claim
25 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which a polivirus antigenic peptide is joined by a covalent bond.
Claim 35
Dependent Claim
25 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which a polivirus antigenic peptide is joined by a covalent bond.
Claim 36
Dependent Claim
51 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which a poliovirus antigenic peptide is joined by a covalent bond.
Claim 37
Dependent Claim
51 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which a poliovirus antigenic peptide is joined by a covalent bond.
Claim 38
Dependent Claim
22 words
The antigenic product of claim 21 or 22 wherein the antigenic peptide is selected from the group consisting of: Tyr-Ser-Thr-Leu-Ryr-Arg-Trp-Leu-Asp-Aso-Ser-Phe and Asn-Ala-Pro-Ser-Lys-Thr-Lys-Leu-Glu-Pro-Ser-Ala-Phe.
Claim 39
Dependent Claim
28 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which a foot and mouth disease antigenic peptide is joined by a covalent bond.
Claim 40
Dependent Claim
28 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which a foot and mouth disease antigenic peptide is joined by a covalent bond.
Claim 41
Dependent Claim
54 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide brances are joined through peptide bonds, said branches having terminal functional groups to which a foot and mouth disease antigenic peptide is joined by a covalent bond.
Claim 42
Dependent Claim
54 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide brances are joined through peptide bonds, said branches having terminal functional groups to which a foot and mouth disease antigenic peptide is joined by a covalent bond.
Claim 43
Dependent Claim
22 words
The antigenic product of claim 24 or 25 wherein the antigenic peptide is selected from the group consisting of: Gly-Ser-Gly-Val-Arg-Gly-Asp-Ser-Gly-Ser-Leu-Ala-Leu-Arg-Val-Ala-Arg-Gln-Leu-Pro and Arg-His-Lys-Gln-Lys-Ile-Val-Ala-Pro-Val-Lys-Gln-Thr-Leu.
Claim 44
Dependent Claim
26 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which an influenza virus antigenic peptide is joined by a covalent bond.
Claim 45
Dependent Claim
26 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which an influenza virus antigenic peptide is joined by a covalent bond.
Claim 46
Dependent Claim
52 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which an influenza virus antigenic peptide is joined by a covalent bond.
Claim 47
Dependent Claim
52 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which an influenza virus antigenic peptide is joined by a covalent bond.
Claim 48
Dependent Claim
22 words
The antigenic product of claim 27 or 28 wherein the antigenic peptide is selected from the group consisting of: Gly-Lue-Phe-Gly-Ala-Ile-Ala-Gly-Phe-Ile-Glu and Arg-Ser-Lys-Ala-Phe-Ser-Asn-Cys-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-Ser.
Claim 49
Dependent Claim
24 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which HIV antigenic peptide is joined by a covalent bond.
Claim 50
Dependent Claim
24 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues to which HIV antigenic peptide is joined by a covalent bond.
Claim 51
Dependent Claim
50 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which HIV antigenic peptide is joined by a covalent bond.
Claim 52
Dependent Claim
50 words
An antigenic product comprising a dendritic homopolymer containing up to 10 monomeric residues the core molecule of which contains at least two amino groups to which polyamide branches are joined through peptide bonds, said branches having terminal functional groups to which HIV antigenic peptide is joined by a covalent bond.
Claim 53
Dependent Claim
14 words
The antigenic product of claim 30 or 31 wherein the antigenic peptide is: Arg-Ile-Leu-Ala-Val-Glu-Arg-Tyr-Leu-Lys-Asp-Gln-Gln-Leu-Leu-Gly-Ile-Trp-Gly-Cys-Ser.
Claim 54
Dependent Claim
16 words
An antigenic product of claim 1 or 2 in which the antigenic molecule is a peptide.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1996-07-19 | 1997-01-18 | 1997-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-19 | 2001-01-18 | 2001-07-20 | $3760.00 | Window Closed / Lapsed |
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