US5224926A
Expired / Lapsed
US
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Transvivo plasma extraction catheter device
Assignee: Matria Healthcare LLC
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Filing: 1991-08-16
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Granted: 1993-07-06
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Expires: 2011-08-16
Abstract
Abstract A device for being implanted in a blood vessel for carrying out continuous in vivo plasma separation comprises an elongated, axial header and at least one elongated microporous fiber having a hollow interior, said fiber being dimensioned to be received within a blood vessel without significantly obstructing fluid flow through said blood vessel, the pore size of said fiber being sufficient to allow plasma to diffuse through said pores into said hollow interior of said fiber but not sufficient to allow cellular components larger than plasma to diffuse therethrough, said one or more fibers extending laterally relative to the axis of said header and in fluid communication with said header. In another embodiment, the fibers comprise a drogue-shaped device comprising a plurality of said fibers aligned lengthwise, a first end of said fibers terminating substantially in first plane and generally forming an annulus having a first diameter, and a second end of said fibers terminating generally in a second plane and secured in an annular header having a second diameter smaller than said first diameter.
Inventors
- 👤 Reynolds G. F. Gorsuch
- 👤 John Atkin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 19:36
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14525; A61B5/14528; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1678; A61B5/1455; A61B5/14551; A61B5/14557; A61M1/34; A61M2205/00; A61M2205/33; A61M2205/3331; A61M2205/35; A61M2205/3546; A61M2205/3553; A61M2205/3576; A61M2205/3584
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
126 words
A device for being implanted in a blood vessel for carrying out continuous in vivo plasma separation comprising an elongated, axial header having an elongated exterior surface, and at least one elongated microporous fiber having a hollow interior, said fiber being dimensioned to be received within a blood vessel without significantly obstructing fluid flow through said blood vessel, the pore size of said fiber being sufficient to allow plasma to diffuse through said pores into said hollow interior of said fiber but not sufficient to allow cellular components larger than plasma to diffuse therethrough, said one or more fibers secured along and extending from said elongated exterior surface of said header and extending laterally relative to the axis thereof, and in fluid communication with said header.
Claim 2
Independent Claim
126 words
A device for being implanted in a blood vessel for carrying out continuous in vivo plasma separation comprising an elongated, axial header having an elongated exterior surface, and at least one elongated microporous fiber having a hollow interior, said fiber being dimensioned to be received within a blood vessel without significantly obstructing fluid flow through said blood vessel, the pore size of said fiber being sufficient to allow plasma to diffuse through said pores into said hollow interior of said fiber but not sufficient to allow cellular components larger than plasma to diffuse therethrough, said one or more fibers secured along and extending from said elongated exterior surface of said header and extending laterally relative to the axis thereof, and in fluid communication with said header.
Claim 3
Dependent Claim
14 words
A device of claim 1 wherein said fiber comprises a plurality of looped branches.
Claim 4
Dependent Claim
16 words
A device of claim 2 wherein said branches extend substantially normal and radially from said header.
Claim 5
Dependent Claim
21 words
A device of claim 1 wherein said fiber comprises a plurality of fibers extending substantially normal and radially from said header.
Claim 6
Dependent Claim
20 words
A device of claim 4 wherein said fibers comprise a plurality of substantially planar ribs extending radially from said header.
Claim 7
Dependent Claim
23 words
A device of claim 5 wherein the plane of each of said planar ribs lies substantially parallel with the axis of said header.
Claim 8
Dependent Claim
37 words
A device of claim 1 wherein said one or more of said fibers extend substantially radially from said header in the form of a pattern and wherein said pattern for each of said devices is substantially identical.
Claim 9
Dependent Claim
20 words
A device of claim 1 comprising a plurality of said fibers each having a first end secured in said header.
Claim 10
Dependent Claim
21 words
A device of claim 1 wherein said fibers have a flux coefficient of between about 0.8 and about 2.5 ml/min/sqcm/0.1 bar.
Claim 11
Dependent Claim
19 words
A device of claim 1 wherein said fibers have a flux coefficient of at least 1.8 ml/min/sq cm/0.1 bar.
Claim 12
Dependent Claim
14 words
A device of claim 1 wherein said fiber is composed of a polymeric material.
Claim 13
Dependent Claim
11 words
A device of claim 11 wherein said polymeric material is polypropylene.
Claim 14
Dependent Claim
19 words
A device of claim 11 wherein said fiber has a pore size of from about 0.1 to 1.0 μm.
Claim 15
Dependent Claim
84 words
An apparatus comprising the device of claim 1 wherein said hollow interior of said elongated fibers is in fluid communication with a means for conducting plasma comprising a first discrete hollow tube which connects to one end of the fibers and permits passage of plasma from said hollow interior of said fibers and a second discrete hollow tube which returns plasma to said blood vessel such that plasma being removed from said fibers is kept separated from plasma being returned to the blood vessel.
Claim 16
Dependent Claim
38 words
An apparatus of claim 14, further comprising a treatment system in fluid communication with said fibers, whereby selected subcomponents of said plasma removed from said blood vessel are treated and the treated plasma returned to said blood vessel.
Claim 17
Dependent Claim
138 words
In an apparatus for continuous in vivo plasma separation, comprising: at least one elongated microporous fiber having a hollow interior, said fiber being dimensioned to be received within a blood vessel without significantly obstructing fluid flow through said blood vessel, the pore size of said fiber being sufficient to allow plasma to diffuse through said pores into said hollow interior of said fiber but not sufficient to allow cellular components larger than plasma to diffuse therethrough, the improvement comprising a drogue-shaped device comprising a plurality of said fibers aligned lengthwise, a first end of said fibers terminating substantially in first plane and generally forming an annulus having a first diameter, and a second end of said fibers terminating generally in a second plane and secured in an annular header having a second diameter smaller than said first diameter.
Claim 18
Dependent Claim
138 words
In an apparatus for continuous in vivo plasma separation, comprising: at least one elongated microporous fiber having a hollow interior, said fiber being dimensioned to be received within a blood vessel without significantly obstructing fluid flow through said blood vessel, the pore size of said fiber being sufficient to allow plasma to diffuse through said pores into said hollow interior of said fiber but not sufficient to allow cellular components larger than plasma to diffuse therethrough, the improvement comprising a drogue-shaped device comprising a plurality of said fibers aligned lengthwise, a first end of said fibers terminating substantially in first plane and generally forming an annulus having a first diameter, and a second end of said fibers terminating generally in a second plane and secured in an annular header having a second diameter smaller than said first diameter.
Claim 19
Dependent Claim
18 words
An apparatus of claim 16 wherein said header is in fluid communication with the interior of said fibers.
Claim 20
Dependent Claim
17 words
An apparatus of claim 17 including a catheter secured in said header and in fluid communication therewith.
Claim 21
Dependent Claim
18 words
An apparatus of claim 16 wherein said device comprises a single layer of adjacent fibers along said annulus.
Claim 22
Dependent Claim
14 words
An apparatus of claim 19 wherein said fibers are overlapped adjacent said annular header.
Claim 23
Dependent Claim
18 words
An apparatus of claim 18 comprising a plurality of said devices secured axially in series along said catheter.
Claim 24
Dependent Claim
21 words
Apparatus of claim 16 wherein said fibers have a flux coefficient of between about 0.8 and about 2.5 ml/min/sq cm/0.1 bar.
Claim 25
Dependent Claim
19 words
An apparatus of claim 16 wherein said fibers have a flux coefficient of at least 1.8 ml/min/sq cm/0.1 bar.
Claim 26
Dependent Claim
14 words
The apparatus of claim 16 wherein said fiber is composed of a polymeric material.
Claim 27
Dependent Claim
11 words
The apparatus of claim 24 wherein said polymeric material is polypropylene.
Claim 28
Dependent Claim
19 words
The apparatus of claim 25 wherein said fiber has a pore size of from about 0.1 to 1.0 μm.
Claim 29
Dependent Claim
81 words
The apparatus of claim 16 wherein said hollow interior of said elongated fibers is in fluid communication with a means for conducting plasma comprising a first discrete hollow tube which connects to one end of the fibers and permits passage of plasma from said hollow interior of said fibers and a second discrete hollow tube which returns plasma to said blood vessel such that plasma being removed from said fibers is kept separated from plasma being returned to the blood vessel.
Claim 30
Dependent Claim
38 words
The apparatus of claim 27, further comprising a treatment system in fluid communication with said fibers, whereby selected subcomponents of said plasma removed from said blood vessel are treated and the treated plasma returned to said blood vessel.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-05 | 1997-01-04 | 1997-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-05 | 2001-01-04 | 2001-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-05 | 2005-01-04 | 2005-07-06 | $7700.00 | Window Closed / Lapsed |