US5223538A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Superoxide dismutase mimic
Assignee: Duke University
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Filing: 1987-03-31
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Granted: 1993-06-29
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Expires: 2007-03-31
Abstract
Abstract The invention relates to a water-soluble complex formed between a chelating agent and manganese and pharmaceutical compositions thereof. The complex is a low molecular weight mimic of superoxide dismutase. The invention further relates to a method of using the complex comprising treating plant and animal cells with an amount of the complex sufficient to reduce or prevent superoxide radical-induced toxicity.
Inventors
- 👤 Irwin Fridovich
- 👤 Douglas J. Darr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 17:54
CPC Classifications
A; A01; A01N; A01N3/00; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A01N25/00; A01N25/32; A01N37/00; A01N37/18; A01N37/30; A01N59/00; A01N59/16; A61; A61P; A61P29/00; A61P9/00; A61P9/10; C; C07; C07F; C07F13/00; C07F13/005; Y; Y10; Y10S; Y10S424/00; Y10S424/06
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
55 words
A method of protecting cells from the toxicity of superoxide radicals comprising treating said cells with an amount of a water-soluble complex formed between a chelating agent and manganese sufficient to reduce or prevent superoxide radical-induced toxicity, wherein said chelating agent is a hydroxamate-type siderophore, or analog or derivative thereof capable of forming said complex.
Claim 2
Independent Claim
55 words
A method of protecting cells from the toxicity of superoxide radicals comprising treating said cells with an amount of a water-soluble complex formed between a chelating agent and manganese sufficient to reduce or prevent superoxide radical-induced toxicity, wherein said chelating agent is a hydroxamate-type siderophore, or analog or derivative thereof capable of forming said complex.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein said cells are mammalian cells.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein said cells are plant cells.
Claim 5
Dependent Claim
22 words
A method according to claim 1 wherein said chelating agent is desferrioxamine or analog or derivative thereof capable of forming said complex.
Claim 6
Dependent Claim
15 words
A method according to claim 1 wherein said manganese has an effective valence of four.
Claim 7
Dependent Claim
15 words
A method according to claim 1 wherein said superoxide-radicals are the result of reperfusion injuries.
Claim 8
Dependent Claim
15 words
A method according to claim 1 wherein said superoxide-radicals are the result of inflammatory diseases.
Claim 9
Independent Claim
63 words
A method of inhibiting damage due to auto-oxidation of a substance with the subsequent formation of O 2 - comprising adding to said substance an amount of a water soluble complex formed between a chelating agent and manganese sufficient to reduce or prevent oxidation damage, wherein said chelating agent is a hydroxamate-type siderophore, or analog or derivative thereof capable of forming said complex.
Claim 10
Independent Claim
63 words
A method of inhibiting damage due to auto-oxidation of a substance with the subsequent formation of O 2 - comprising adding to said substance an amount of a water soluble complex formed between a chelating agent and manganese sufficient to reduce or prevent oxidation damage, wherein said chelating agent is a hydroxamate-type siderophore, or analog or derivative thereof capable of forming said complex.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-28 | 1996-12-28 | 1997-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-28 | 2000-12-28 | 2001-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-28 | 2004-12-28 | 2005-06-29 | $7700.00 | Window Closed / Lapsed |