US5223241A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for early detection of allograft rejection
Assignee: General Hospital Corp
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Filing: 1991-08-16
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Granted: 1993-06-29
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Expires: 2011-08-16
Abstract
Abstract The invention relates to a method of detecting early rejection of an allograft in a mammal by administering to the mammal a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site of allograft rejection. The method of the invention may also be used to monitor allograft rejection during immunosuppressive therapy in a mammal which has received an allograft or to localize areas involved in autoimmune disease or inflammation.
Inventors
- 👤 Mitsuaki Isobe
- 👤 Ban A. Khaw
- 👤 Edgar Haber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:07
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1027; A61K2123/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
67 words
A method for detecting rejection of an allograft in a mammal, said method comprising: (a) administering to said mammal an effective amount of a composition comprising at least one monospecific immunoglobulin molecule or fragment thereof diagnostically conjugated to a detectable label, said immunoglobulin or fragment directed against an MHC antigen; and (b) detecting rejection of said allograft, by detecting the presence of said labelled immunoglobulin or fragment.
Claim 2
Independent Claim
67 words
A method for detecting rejection of an allograft in a mammal, said method comprising: (a) administering to said mammal an effective amount of a composition comprising at least one monospecific immunoglobulin molecule or fragment thereof diagnostically conjugated to a detectable label, said immunoglobulin or fragment directed against an MHC antigen; and (b) detecting rejection of said allograft, by detecting the presence of said labelled immunoglobulin or fragment.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein said immunoglobulin is directed against MHC Class 2 antigens.
Claim 4
Dependent Claim
22 words
The method of claim 1 wherein said immunoglobulin is selected from the group consisting of a monoclonal antibody and a polyclonal antibody.
Claim 5
Dependent Claim
19 words
The method of claim 3 wherein said monoclonal antibody is chosen from the group containing anti-HLA DR and W6/32.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein said detectable label is a radioactive isotope.
Claim 7
Dependent Claim
37 words
The method of claim 5 wherein said radioactive isotope is chosen from the group consisting of 111 In, 99m Tc, 123 I, 97 Rv, 67 Cu, 67 Ga, 68 Ga, 72 As, 89 Zr and 201 Tl.
Claim 8
Dependent Claim
14 words
The method of claim 1, wherein said allograft is a heart or kidney allograft.
Claim 9
Dependent Claim
12 words
The method of claim 7, wherein said allograft is a heart allograft.
Claim 10
Dependent Claim
12 words
The method of claim 7, wherein said allograft is a kidney allograft.
Claim 11
Dependent Claim
13 words
The method of claim 1 wherein said detectable label is a paramagnetic isotope.
Claim 12
Dependent Claim
27 words
The method of claim 10 wherein said paramagnetic isotope is chosen from the group consisting of 157 Ad, 55 Mn, 162 Dy, 52 Cr and 56 Fe.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-28 | 1996-12-28 | 1997-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-28 | 2000-12-28 | 2001-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-28 | 2004-12-28 | 2005-06-29 | $7700.00 | Window Closed / Lapsed |