US5219346A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Light diffuser for the photodynamic therapy of tumors in the oesophagus of a patient
Assignee: Novartis Corp
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Filing: 1991-01-04
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Granted: 1993-06-15
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Expires: 2011-01-04
Abstract
Abstract A light diffuser for simultaneous photodynamic therapy and hyperthermic treatment in the oesophagus has an arrangement (14 to 18) which disperses radially the light (10) fed in by way of an optical fiber (6) and has a tube (12) filled with silicone to which are added concentrations, modulated in the axial direction, of quartz grains having a diameter of approximately 40 μm which bring about a refraction having little dependence on the wavelength.
Inventors
- 👤 Georges Wagnieres
- 👤 Hubert van den Bergh
- 👤 Philippe Monnier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:25
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/06; A61N5/0613; A61N5/062; A61N5/0601; A61B; A61B18/00; A61B18/18; A61B18/20; A61B18/22; A61B2018/2255; A61B2018/2261; A61B90/00; A61B90/39; A61N5/0603; A61N2005/0609
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
211 words
A light diffuser for photodynamic therapy of a tumor in an oesophagus of a patient, said diffuser comprising (a) a tube having a front portion and a rear portion; (b) an optical fiber for feeding laser light of a specified wavelength axial into said tube through said rear portion toward said front portion; (c) composition, including quartz grains embedded therein, contained within said tube between said rear portion and said front portion, said composition having a first refractive index and said quartz grains having a second refractive index different from said first refractive index, wherein said quartz grains have a large diameter relative to said specified wavelength of the laser light, said composition having a plurality of different regions including at least a first region and a final region arranged axially, with said final region of said plurality of regions proximal to said front portion of said tube, wherein said quartz grains embedded in the composition are of different concentrations in the different regions; (d) a mirror located within said tube between said composition and said front portion opposite said optical fiber; and (e) a sleeve-shaped probe housing wherein said tube, fiber, composition and mirror are arranged coaxially such that the laser light is deflected radially outward from said probe housing.
Claim 2
Dependent Claim
211 words
A light diffuser for photodynamic therapy of a tumor in an oesophagus of a patient, said diffuser comprising (a) a tube having a front portion and a rear portion; (b) an optical fiber for feeding laser light of a specified wavelength axial into said tube through said rear portion toward said front portion; (c) composition, including quartz grains embedded therein, contained within said tube between said rear portion and said front portion, said composition having a first refractive index and said quartz grains having a second refractive index different from said first refractive index, wherein said quartz grains have a large diameter relative to said specified wavelength of the laser light, said composition having a plurality of different regions including at least a first region and a final region arranged axially, with said final region of said plurality of regions proximal to said front portion of said tube, wherein said quartz grains embedded in the composition are of different concentrations in the different regions; (d) a mirror located within said tube between said composition and said front portion opposite said optical fiber; and (e) a sleeve-shaped probe housing wherein said tube, fiber, composition and mirror are arranged coaxially such that the laser light is deflected radially outward from said probe housing.
Claim 3
Dependent Claim
17 words
The light diffuser of claim 1, wherein the diameter of the quartz grains is approximately 40 μm.
Claim 4
Dependent Claim
47 words
The light diffuser of claim 1, wherein the composition in said first region is struck directly by said laser light and wherein the concentration of quartz grains in the first region is higher than the concentration of quartz grains in the plurality of regions of the composition.
Claim 5
Dependent Claim
64 words
The light diffuser of claim 3, wherein the plurality of regions includes an intermediate region containing a low concentration of said quartz grains, said intermediate region being located between said first region and said final region, and wherein said final region has a concentration of quartz grains less than the concentration of the first region and more than the concentration of the intermediate region.
Claim 6
Dependent Claim
44 words
The light diffuser of claim 4, wherein the plurality of regions further includes an additional region situated between said first region and said intermediate region, and wherein the additional region has a concentration of quartz grains less than the concentration of the intermediate region.
Claim 7
Dependent Claim
21 words
The light diffuser of claim 1, wherein said probe housing has a surface and a thermoelement is provided in said surface.
Claim 8
Dependent Claim
16 words
The light diffuser of claim 6, wherein said thermoelement is connected to a thermal monitoring device.
Claim 9
Dependent Claim
72 words
The light diffuser of claim 1, further comprising a light-monitoring fiber having an end face, said end face being arranged in a laterally offset manner near said optical fiber and wherein said light-monitoring fiber is situated inside the sleeve-shaped probe housing and outside the front portion of the tube such that the light-monitoring fiber is contacted by the laser light before the laser light is deflected radially outward from the probe housing.
Claim 10
Dependent Claim
19 words
The light diffuser of claim 8, wherein said light-monitoring fiber is connected to a light-intensity control and monitoring device.
Claim 11
Dependent Claim
11 words
The light diffuser of claim 1, wherein said composition includes silicone.
Claim 12
Dependent Claim
18 words
The light diffuser of claim 10, wherein said composition consists essentially of silicone and quartz grains embedded therein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-14 | 1996-12-14 | 1997-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-14 | 2000-12-14 | 2001-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-14 | 2004-12-14 | 2005-06-15 | $7700.00 | Window Closed / Lapsed |