US5215982A
Expired / Lapsed
US
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Cephem compounds
Assignee: Astellas Pharma Inc
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Filing: 1990-10-26
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Granted: 1993-06-01
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Expires: 2010-10-26
Abstract
Abstract Cephem compounds of the following formula are disclosed: ##STR1## wherein R 1 is amino or protected amino group. R 2 is H or an organic group, R 3 is H or an organic group, R 4 is H, lower alkyl, carboxy, protected carboxy, amino, protected amino or carbamoyl, Z=N or CH. The compounds are useful as antimicrobial agents.
Inventors
- 👤 Kazuo Sakane
- 👤 Kohji Kawabata
- 👤 Yoshiko Inamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 18:05
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/38; A; A61; A61P; A61P31/00; A61P31/04; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
91 words
A compound of the formula: ##STR8## wherein R 1 is amino or a protected amino group, R 2 is hydrogen, lower alkyl, mono(or di or tri)halo(lower)alkyl, lower alkenyl, lower alkynyl, phenyl, naphthyl, phenyl-(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, hydroxy-(lower)alkyl, protected hydroxy(lower)-alkyl or a hydroxy protective group, R 3 is hydrogen, lower alkyl, hydroxy(lower) alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino-(lower)alkyl, carbamoyl(lower)alkyl, N,N-di(lower)alkylcarbamoyl(lower) alkyl or an imino protective group, R 4 is hydrogen, lower alkyl, carboxy, protected carboxy, amino, protected amino or carbamoyl, and Z is N or CH, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
91 words
A compound of the formula: ##STR8## wherein R 1 is amino or a protected amino group, R 2 is hydrogen, lower alkyl, mono(or di or tri)halo(lower)alkyl, lower alkenyl, lower alkynyl, phenyl, naphthyl, phenyl-(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, hydroxy-(lower)alkyl, protected hydroxy(lower)-alkyl or a hydroxy protective group, R 3 is hydrogen, lower alkyl, hydroxy(lower) alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino-(lower)alkyl, carbamoyl(lower)alkyl, N,N-di(lower)alkylcarbamoyl(lower) alkyl or an imino protective group, R 4 is hydrogen, lower alkyl, carboxy, protected carboxy, amino, protected amino or carbamoyl, and Z is N or CH, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
25 words
A compound of claim 1, wherein R 2 is hydrogen, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or a hydroxy protective group.
Claim 4
Dependent Claim
52 words
A compound of claim 2, wherein R 1 is amino, R 2 is hydrogen, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, carboxy(lower)alkyl, esterified carboxy(lower)alkyl or lower alkanoyl, R 3 is hydrogen, lower alkyl, hydroxy(lower)-alkyl, amino(lower)alkanoylamino(lower)-alkyl, carbamoyl(lower)alkyl, N,N-di(lower)alkylcarbamoyl(lower)alkyl, or N,N-di(lower)alkylcarbamoyl, and R 4 is hydrogen, lower alkyl, carboxy, esterified carboxy, amino, lower alkanoylamino or carbamoyl.
Claim 5
Dependent Claim
52 words
A compound of claim 3, wherein ρR 1 is amino, R 2 is hydrogen, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, carboxy(lower)alkyl or lower alkanoyl, R 3 is hydrogen, lower alkyl, hydroxy(lower)-alkyl, amino(lower)alkyl, lower alkanoylamino(lower)alkyl, carbamoyl(lower)alkyl, N,N-di(lower)alkylcarbamoyl(lower)alkyl or N,N-di(lower)alkylcarbamoyl, and R 4 is hydrogen, lower alkyl, carboxy, lower alkoxycarbonyl, amino, lower alkanoylamino or carbamoyl.
Claim 6
Dependent Claim
31 words
An antimicrobial pharmaceutical composition which comprises as an active ingredient, an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof in admixture with pharmaceutically acceptable carriers.
Claim 7
Dependent Claim
31 words
A method for the treatment of infectious diseases which comprises administering an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof to a human or animal.
References Cited (Backward Citations)
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