US5213898A
Expired / Lapsed
US
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Process for the preparation of surface modified solid substrates
Assignee: Carmeda AB
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Filing: 1991-06-14
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Granted: 1993-05-25
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Expires: 2011-06-14
Abstract
Abstract Method for surface modifying substrates characterized in adsorbing on the surface of a solid substrate a polyamine of a high average molecular weight and cross-linking this with crotonaldehyde either simultaneously or by addition in separate steps to produce amino groups on the surface of the substrate, and optionally adsorbing one or several alternating layers of an anionic polysaccharide and of the said polyamine being cross-linked with crotonaldehyde, and optionally finally adsorbing the said polyamine, not cross-linked, to produce free primary amino groups by which chemical entities having a biological activity may be bound by covalent or ionic bonding.
Inventors
- 👤 Karl O. P. Larm
- 👤 Lars A. Adolfsson
- 👤 Kjell P. Olsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:07
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; C; C08; C08G; C08G73/00; C08G73/02; C08G73/0206; C08J; C08J7/00; C08J7/04; C08J7/042; C08J7/0427; C08L; C08L79/00; C08L79/02; C08J2323/00; C08J2323/02; C08J2323/04; C08J2323/06; C08J2405/00; C08J2405/02; C08J2479/00; C08J2479/02; C08L23/00; C08L25/00; C08L25/02; C08L25/04; C08L25/06; C08L27/00; C08L27/02; C08L27/04; C08L27/06; C08L27/12; C08L27/18; C08L75/00; C08L75/04; C08L83/00; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/813; Y10T; Y10T428/00; Y10T428/12; Y10T428/12222; Y10T428/24; Y10T428/24058; Y10T428/24074; Y10T428/24091; Y10T428/24099; Y10T428/24107; Y10T428/24479; Y10T428/24496; Y10T428/31; Y10T428/31504; Y10T428/3154; Y10T428/31544; Y10T428/31551; Y10T428/31652; Y10T428/31663; Y10T428/31678; Y10T428/31681; Y10T428/31855; Y10T428/31935; Y10T428/31938; Y10T428/31971
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
43 words
In a surface modified substrate having free primary amino groups on the surface to bind a biologically active material, the improvement wherein the surface modified substrate comprises a layer of a polyamine having a high average molecular weight which is cross-linked with crotonaldehyde.
Claim 2
Dependent Claim
43 words
In a surface modified substrate having free primary amino groups on the surface to bind a biologically active material, the improvement wherein the surface modified substrate comprises a layer of a polyamine having a high average molecular weight which is cross-linked with crotonaldehyde.
Claim 3
Dependent Claim
34 words
A surface modified substrate according to claim 1 wherein the said layer of polyamine cross-linked with crotonaldehyde is achieved by applying to a solid substrate an aqueous solution containing the polyamine and the crotonaldehyde.
Claim 4
Dependent Claim
37 words
A surface modified substrate according to claim 1 wherein a polyamine is first absorbed onto the surface of a solid substrate and the thus treated substrate is then contacted with a solution containing crotonaldehyde to achieve cross-linking.
Claim 5
Dependent Claim
45 words
A surface modified substrate according to claim 1 wherein following the obtaining of the layer of the polyamine cross-linked with crotonaldehyde there is applied to the resultant substrate a solution of an anionic polysaccharide to obtain at least one adsorbed layer of said anionic polysaccharide.
Claim 6
Dependent Claim
32 words
A surface modified substrate according to claim 4 containing a plurality of adsorbed layers of anionic polysaccharide, each of said layers alternating with an adsorbed layer of the polyamine cross-linked with crotonaldehyde.
Claim 7
Dependent Claim
42 words
A surface modified substrate according to claim 1 wherein the final layer on the treated surface of the substrate is an adsorbed layer of a high average molecular weight polyamine which is not cross-linked in order to provide free primary amino groups.
Claim 8
Dependent Claim
42 words
A surface modified substrate according to claim 4 wherein the final layer on the treated surface of the substrate is an adsorbed layer of a high average molecular weight polyamine which is not cross-linked in order to provide free primary amino groups.
Claim 9
Dependent Claim
16 words
A surface modified substrate according to claim 6 wherein the free primary amino groups are quaternized.
Claim 10
Dependent Claim
17 words
A surface modified substrate according to claim 7 wherein the free primary amino groups are subsequently quaternized.
Claim 11
Dependent Claim
26 words
A surface modified substrate according to claim 1 wherein the substrate is a member selected from the group consisting of metal, glass and a polymeric material.
Claim 12
Dependent Claim
24 words
A surface modified substrate according to claim 10 wherein the substrate is a member selected from the group consisting of stainless steel and aluminum.
Claim 13
Dependent Claim
28 words
A surface modified substrate according to claim 10, wherein the substrate is a member selected from the group consisting of polyvinylchloride, polyurethane, silicon rubber, polytetrafluoroethylene, polystyrene and polyolefin.
Claim 14
Dependent Claim
14 words
A surface modified substrate according to claim 4 wherein the polysaccharide is dextran sulfate.
Claim 15
Dependent Claim
13 words
A surface modified substrate according to claim 1 wherein the polyamine is polyethylenimine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-05-24 | 1996-11-23 | 1997-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-05-24 | 2000-11-23 | 2001-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-05-24 | 2004-11-23 | 2005-05-25 | $7700.00 | Window Closed / Lapsed |