US5202332A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Rapamycin analog as immunosuppressant
Assignee: Wyeth LLC
•
Filing: 1992-08-05
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Granted: 1993-04-13
•
Expires: 2012-08-05
Abstract
Abstract Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities.
Inventors
- 👤 Philip F. Hughes
- 👤 John H. Musser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:47
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/12; C07D498/18; C07H; C07H19/00; C07H19/01
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
38 words
A method of treating transplantation rejection, host vs. graft disease, autoimmune diseases, and diseases of inflammation in a mammal by administering thereto an effective amount of a compound having the formula ##STR5## or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
38 words
A method of treating transplantation rejection, host vs. graft disease, autoimmune diseases, and diseases of inflammation in a mammal by administering thereto an effective amount of a compound having the formula ##STR5## or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US5120726A
Cited
US5138051A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-04-12 | 1996-10-12 | 1997-04-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-04-12 | 2000-10-12 | 2001-04-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-04-12 | 2004-10-12 | 2005-04-13 | $7700.00 | Window Closed / Lapsed |