US5196515A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
Assignee: Johns Hopkins University
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Filing: 1991-09-06
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Granted: 1993-03-23
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Expires: 2011-09-06
Abstract
Abstract A bifunctional ligand to compositions produced by reaction of the ligand with compounds containing an amino, thiolate or alcholate group, especially proteins, to chelates produced by complexing ligands with metal such as technetium and rhenium and to diagnostic and therapeutic uses of the complexes.
Inventors
- 👤 Susan Z. Lever
- 👤 Kwamena E. Baidoo
- 👤 Alfred V. Kramer
- 👤 Hugh D. Burns
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:16
CPC Classifications
C; C07; C07D; C07D285/00; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K51/00; A61K51/02; A61K51/04; A61K51/0497; A61K51/08; A61K51/081; A61K51/088; A61K51/10; A61K51/1045; A61K51/1093; C07C; C07C323/00; C07C323/23; C07C323/24; C07C323/25; C07D279/00; C07D279/10; C07D279/12; C07D513/00; C07D513/02; C07D513/04; A61K2123/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
148 words
A ligand capable of forming a coordination complex with a metal, said ligand comprising the reaction product of: (i) a bifunctional ligand capable of reaction with a protein, protein fragment, peptide, amino acid, natural or synthetic analogs thereof or simple molecules containing amino, thiolate, alcholate or other nucleophilic group capable of reacting with a thiolactone and a metal, said ligand having the structure: ##STR2## wherein each R' is independently a hydrogen atom or an alkyl group or substituted alkyl group; each R'' is independently a hydrogen atom, an alkyl group or the defined group, R''' is independently a hydrogen atom or an alkyl group; m and m 1 are 0 or 1, Z is a hydrogen atom or a labile thiol protecting group, and the simple salts thereof, and (ii) a compound containing an amino, thiolate, alcolate or any other nucleophilic group capable of reacting with a thiolactone.
Claim 2
Dependent Claim
148 words
A ligand capable of forming a coordination complex with a metal, said ligand comprising the reaction product of: (i) a bifunctional ligand capable of reaction with a protein, protein fragment, peptide, amino acid, natural or synthetic analogs thereof or simple molecules containing amino, thiolate, alcholate or other nucleophilic group capable of reacting with a thiolactone and a metal, said ligand having the structure: ##STR2## wherein each R' is independently a hydrogen atom or an alkyl group or substituted alkyl group; each R'' is independently a hydrogen atom, an alkyl group or the defined group, R''' is independently a hydrogen atom or an alkyl group; m and m 1 are 0 or 1, Z is a hydrogen atom or a labile thiol protecting group, and the simple salts thereof, and (ii) a compound containing an amino, thiolate, alcolate or any other nucleophilic group capable of reacting with a thiolactone.
Claim 3
Dependent Claim
32 words
A ligand as set forth in claim 1 in which the compound containing the amino, thiolate or alcolate group is a protein, protein fragment, peptide, amino acid, natural or synthetic analogs thereof.
Claim 4
Dependent Claim
21 words
A ligand as set forth in claim 2 in which the protein of the compound is human serum albumin or fibrinogen.
Claim 5
Dependent Claim
18 words
A ligand as set forth in claim 2 in which the protein of the compound is an antibody.
Claim 6
Dependent Claim
30 words
A ligand as set forth in claim 4, wherein the antibody is selected from the group consisting of anticolon carcinoma monoclonal antibody, anti-Rausher leukemia monoclonal nntibody or polyclonal anti-ferritin antibody.
Claim 7
Dependent Claim
24 words
A ligand as set forth in claim 1 in which the compound containing an amino group is benzylamine or any other amine containing compound.
Claim 8
Dependent Claim
16 words
A coordination compound comprising the technetium 1:1 complex of the ligand set forth in claim 1.
Claim 9
Dependent Claim
16 words
A coordination compound comprising the technetium 1:1 complex of the ligand set forth in claim 3.
Claim 10
Dependent Claim
16 words
A coordination compound comprising the technetium 1:1 complex of the ligand set forth in claim 4.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-03-22 | 1996-09-21 | 1997-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-22 | 2000-09-21 | 2001-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-22 | 2004-09-21 | 2005-03-23 | $7700.00 | Window Closed / Lapsed |