US5196196A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of protease nexin-I in wound dressings
Assignee: Incyte Corp
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Filing: 1992-01-16
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Granted: 1993-03-23
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Expires: 2012-01-16
Abstract
Abstract A method of treating wound healing with a composition containing protease nexin-I (PN-I) is disclosed. Compositions comprised of PN-I uniformly dispersed throughout a pharmaceutically acceptable carrier are disclosed as are such compositions further comprising antibiotics. Wound dressings are taught which are comprised of a support base having an absorbent area thereon which has PN-I absorbed thereon and which absorbent area is surrounded by a pressure sensitive adhesive strip for adhering the dressing to a surface surrounding the wound to be treated.
Inventors
- 👤 Randy W. Scott
- 👤 Richard A. Berg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 15:56
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/44; A61K; A61K38/00; A61K38/16; A61K38/55; A61K38/57; C; C07; C07K; C07K14/00; C07K14/81; C07K14/8107; C07K14/811; C07K14/8121; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/254; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/42; A61L2300/45
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
17 words
A wound dressing, comprising: a support base; and a therapeutically effective amount of purified protease nexin-I thereon.
Claim 2
Dependent Claim
17 words
A wound dressing, comprising: a support base; and a therapeutically effective amount of purified protease nexin-I thereon.
Claim 3
Dependent Claim
18 words
The wound dressing of claim 1, further comprising: a pharmaceutically acceptable carrier having the protease nexin-I dispersed therein.
Claim 4
Dependent Claim
24 words
The wound dressing of claim 2, further comprising: an absorbent material on the support base which absorbent material has the protease nexin-I absorbed thereon.
Claim 5
Dependent Claim
10 words
The wound dressing of claim 3, further comprising: an adhesive.
Claim 6
Dependent Claim
11 words
The wound dressing of claim 2, wherein the carrier is collagen.
Claim 7
Dependent Claim
25 words
The wound dressing of claim 2, wherein the carrier is a material selected from the group consisting of proteoglycan, laminin, fibronectin, hyaluronic acid and gelatin.
Claim 8
Dependent Claim
29 words
The wound dressing of claim 4, further comprising: a therapeutically effective amount of a pharmaceutically acceptable drug selected from the group consisting of heparin, heparan sulfate and dextran sulfate.
Claim 9
Dependent Claim
17 words
The wound dressing of claim 4, further comprising: a therapeutically effective amount of a pharmaceutically acceptable antibiotic.
Claim 10
Dependent Claim
24 words
The wound dressing of claim 8, wherein the antibiotic is selected from the group consisting of Bacitracin, Heomycin, Polymyxin B, gentamicin and silver sulfudiazine.
Claim 11
Dependent Claim
37 words
The wound dressing as claimed in claim 4, further comprising: a therapeutically effective amount of a purified active wound healing component selected from the group consisting of fibroblast growth factor, transform growth factor and epidermal growth factor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-03-22 | 1996-09-21 | 1997-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-22 | 2000-09-21 | 2001-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-22 | 2004-09-21 | 2005-03-23 | $7700.00 | Window Closed / Lapsed |