US5185368A
Expired / Lapsed
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Polyethylene glycol carbamates
Assignee: Novartis Corp
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Filing: 1988-07-20
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Granted: 1993-02-09
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Expires: 2008-07-20
Abstract
Abstract Compounds of the formula ##STR1## in which R is alkyl having up to 4 carbon atoms, n has an average value of at least 9, X is a radical of the formula --C(═O)--(NH--SO 2 ) m -- in which m is 0 or 1 and, if m is 1, the carbonyl group may be bonded to the oxygen atom or to the nitrogen atom, and each of the radicals A 1 , A 2 and A 3 , independently of the others, is hydrogen or an acyl radical, and salts of salt-forming compounds of formula I, as well as metal complexes of compounds of formula I, in which A 1 , A 2 and A 3 , are hydrogen can be used as metal chelators and as auxiliaries in diagnosis.
Inventors
- 👤 Heinrich Peter
- 👤 Theophile Moerker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 11:41
CPC Classifications
C; C07; C07C; C07C235/00; C07C235/02; C07C235/04; C07C235/08; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; C08G65/337; A; A61; A61P; A61P25/00; A61P25/28; A61P39/00; A61P39/02; A61P7/00; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
230 words
A compound of the formula ##STR7## in which R is an alkyl having up to 4 carbon atoms, n has an verage value of at least 9, X is a radical of the formula --C(═O)--(NH--SO 2 ) m -- in which m is 0 or 1 and, if m is 1, the carbonyl group may be bonded to the oxygen atom or to the nitrogen atom, and each of the radicals A 1 , A 2 and A 3 has the same meaning and is hydrogen, or alkanoyl or alkenoyl each having upto and including 20 carbon atoms, alkoxycarbonyl having up to and including 20 carbon atoms in the alkyl moiety, oxaalkoxycarbonyl having up to and including 20 carbon atoms in the alkyl moiety and wherein up to and including methylene groups are replaced by oxygen atoms and in each case two carbon atoms separate the oxygen atoms from one another, alkylaminocarbonyl having up to and including 20 carbon atoms in the alkyl moiety, or substituted alkylaminocarconyl having up to and including 20 carbon atoms in the alkyl moiety and being substituted bycarboxy, lower alkoxycarbonyl having up to and including 4 carbon atoms in the lower alkyl moiety, carbamoyl and/or amino, hydroxy, mercapto, lower alkylthio having up to and including 4 carbon atoms, phenyl, or by hydroxyphenyl, or a pharmaceutically acceptable salt of a salt forming compound of formula I.
Claim 2
Dependent Claim
230 words
A compound of the formula ##STR7## in which R is an alkyl having up to 4 carbon atoms, n has an verage value of at least 9, X is a radical of the formula --C(═O)--(NH--SO 2 ) m -- in which m is 0 or 1 and, if m is 1, the carbonyl group may be bonded to the oxygen atom or to the nitrogen atom, and each of the radicals A 1 , A 2 and A 3 has the same meaning and is hydrogen, or alkanoyl or alkenoyl each having upto and including 20 carbon atoms, alkoxycarbonyl having up to and including 20 carbon atoms in the alkyl moiety, oxaalkoxycarbonyl having up to and including 20 carbon atoms in the alkyl moiety and wherein up to and including methylene groups are replaced by oxygen atoms and in each case two carbon atoms separate the oxygen atoms from one another, alkylaminocarbonyl having up to and including 20 carbon atoms in the alkyl moiety, or substituted alkylaminocarconyl having up to and including 20 carbon atoms in the alkyl moiety and being substituted bycarboxy, lower alkoxycarbonyl having up to and including 4 carbon atoms in the lower alkyl moiety, carbamoyl and/or amino, hydroxy, mercapto, lower alkylthio having up to and including 4 carbon atoms, phenyl, or by hydroxyphenyl, or a pharmaceutically acceptable salt of a salt forming compound of formula I.
Claim 3
Dependent Claim
53 words
A compound of formula I according to claim 1 in which R is methyl, X has the meaning given in claim 1 and m is 0, n has an average value of from approximately 10 to approximately 17, and each of the radicals A 1 , A 2 and A 3 is hydrogen.
Claim 4
Dependent Claim
35 words
A compound according to claim 1 and being N-[ω-methoxy-(dodecakis-ethyleneoxy)-carbonyl]-desferrioxamine B, in which dodecakis-ethyleneoxy denotes a radical of the formula --(CH 2 --CH 2 --O) n -- in which n has an average value of 12.
Claim 5
Dependent Claim
35 words
A compound according to claim 1 and being N-[ω-methoxy-(heptadecakis-ethyleneoxy)-carbonyl]-desferrioxamine B, in which heptadecakis-ethyleneoxy denotes a radical of the formula --(CH 2 --CH 2 --O) n -- in which n has an average value of 17.
Claim 6
Dependent Claim
35 words
A compound according to claim 1 and being N-[ω-methoxy-(undecakis-ethyleneoxy)-carbonyl]-desferrioxamine B, in which undecakis-ethyleneoxy denotes a radical of the formula --(CH 2 --CH 2 --O) n -- in which n has an average value of 11.
Claim 7
Dependent Claim
35 words
A compound according to claim 1 and being N-[ω-methoxy-(dodecakis-ethyleneoxy)-carbonyl]-O,O',O"-tri-(n-octanoyl)-desferrioxamine B, in which dodecakis-ethyleneoxy denotes a radical of the formula --(CH 2 --CH 2 --O) n -- in which n has an average value of 12.
Claim 8
Dependent Claim
35 words
A compound according to claim 1 and being N-[ω-methoxy-(dodecakis-ethyleneoxy)-carbonyl]-O,O',O"-tri-(ethoxycarbonyl)-desferrioxamine B, in which dodecakis-ethyleneoxy denotes a radical of the formula --(CH 2 --CH 2 --O) n -- in which n has an average value of 12.
Claim 9
Dependent Claim
35 words
A compound according to claim 1 and being N-[ω-methoxy-(dodecakis-ethyleneoxy)-carbonyl]-O,O',O"-tri-(ethoxycarbonylmethylaminocarbonyl)-desferrioxamine B, in which dodecakis-ethyleneoxy denotes a radical of the formula --(CH 2 --CH 2 --O) n -- in which n has an average value of 12.
Claim 10
Dependent Claim
36 words
A compound of formula I according to claim 1 in which n has an average value of from approximately 10 to approximately 17, or a pharmaceutically acceptable salt of such a compound having salt forming properties.
Claim 11
Dependent Claim
149 words
A compound of formula I according to claim 1 in which m is 0, n has an average value of from approximately 10 to approximately 17, and each of the radicals A 1 , A 2 and A 3 , has the same meaning and are hydrogen, alkanoyl having up to and including 12 carbon atoms, alkoxycarbonyl having up to and including 7 carbon atoms in the alkyl group, oxaalkoxycarbonyl having up to and including 7 carbon atoms in the alkyl group wherein one or two methylene groups are replaced by oxygen atoms and oxygen atoms are separated from each other by two carbon atoms, or alkylaminocarbonyl having up to and including 7 carbon atoms in the alkyl group and which is unsubstituted or is substituted in the 1- or 2- position by an alkoxycarbonyl which itself has up to and including 4 carbon atoms in the alkyl portion.
Claim 12
Dependent Claim
44 words
A trivalent metal ion scavenger pharmaceutical composition comprising a trivalent metal ion scavenging effective amount of a compound of claim 1 so as to increase excretion of trivalent metal ions from a mammal to which it is administered and a pharmaceutically acceptable carrier therefor.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-02-09 | 1996-08-10 | 1997-02-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-02-09 | 2000-08-10 | 2001-02-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-02-09 | 2004-08-10 | 2005-02-09 | $7700.00 | Window Closed / Lapsed |