US5182102A
Expired / Lapsed
US
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Anti-glaucoma compositions
Assignee: Alcon Research LLC
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Filing: 1991-07-12
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Granted: 1993-01-26
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Expires: 2011-07-12
Abstract
Abstract Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker to reduce the production of aqueous humor and carbachol to enhance the outflow of aqueous humor. A method of controlling elevated intraocular pressure with those compositions is also described.
Inventors
- 👤 Louis DeSantis, Jr.
- 👤 Rajni Jani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/425; A61K31/21; A61K31/27; A61K31/335; A61K31/34; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/435; A61K31/44; A61K31/445; A61K31/535; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02; A61P27/06
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
51 words
A topical ophthalmic composition for the treatment of glaucoma and ocular hypertensions, comprising: about 0.25 wt% betaxolol; between about 1.5 and about 3.0 wt% carbachol; between about 0.05 and about 8.0 wt% of an anionic mucomimetic polymer; and about 0.05 and about 10.0 wt% of a finely divided cation exchange resin.
Claim 2
Dependent Claim
51 words
A topical ophthalmic composition for the treatment of glaucoma and ocular hypertensions, comprising: about 0.25 wt% betaxolol; between about 1.5 and about 3.0 wt% carbachol; between about 0.05 and about 8.0 wt% of an anionic mucomimetic polymer; and about 0.05 and about 10.0 wt% of a finely divided cation exchange resin.
Claim 3
Dependent Claim
14 words
The composition of claim 1, wherein the concentration of carbachol is about 1.5 wt%.
Claim 4
Dependent Claim
14 words
The composition of claim 1, wherein the concentration of carbachol is about 3.0 wt%.
Claim 5
Independent Claim
57 words
A method for treatment of glaucoma and ocular hypertension, comprising applying to an affected eye a composition comprising: about 0.25 wt% betaxolol; between about 1.5 and about 3.0 wt% carbachol; between about 0.05 and about 8.0 wt% of an anionic mucomimetic polymer; and between about 0.05 and about 10.0 wt% of a finely divided cation exchange resin.
Claim 6
Independent Claim
57 words
A method for treatment of glaucoma and ocular hypertension, comprising applying to an affected eye a composition comprising: about 0.25 wt% betaxolol; between about 1.5 and about 3.0 wt% carbachol; between about 0.05 and about 8.0 wt% of an anionic mucomimetic polymer; and between about 0.05 and about 10.0 wt% of a finely divided cation exchange resin.
Claim 7
Dependent Claim
14 words
The method of claim 4, wherein the concentration of carbachol is about 1.5 wt%.
Claim 8
Dependent Claim
14 words
The method of claim 4, wherein the concentration of carbachol is about 3.0 wt%.
References Cited (Backward Citations)
US4256108A
Cited
US4911920A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-01-26 | 1996-07-27 | 1997-01-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-01-26 | 2000-07-27 | 2001-01-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-01-26 | 2004-07-27 | 2005-01-26 | $7700.00 | Window Closed / Lapsed |