US5171752A
Expired / Lapsed
US
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Benzhydryl derivatives having calmodulin inhibitor properties
Assignee: Organon NV
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Filing: 1991-07-19
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Granted: 1992-12-15
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Expires: 2011-07-19
Abstract
Abstract The invention relates to a benzhydryl derivative having the formula ##STR1## wherein each of the groups R 1 , R 2 , and R 3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF 3 , and at least one of the groups R 1 , R 2 , and R 3 is halogen or CF 3 ; R 4 represents hydrogen or methyl; n is 2, 3, or 4; m is 1, 2, or 3; and X represents O or S; or its pharmaceutically acceptable salts. The benzhydryl derivative of the invention can be used to treat patients who are suffering from diseases which are influenced by calmodulin.
Inventors
- 👤 Patricia Caldirola
- 👤 Raimund Mannhold
- 👤 Hendrik Timmerman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:32
CPC Classifications
C; C07; C07C; C07C215/00; C07C215/46; C07C211/00; C07C211/01; C07C211/26; C07C211/28; A; A61; A61P; A61P3/00; C07C211/27; C07C217/00; C07C217/02; C07C217/04; C07C217/06; C07C217/08; C07C217/10; C07C323/00; C07C323/23; C07C323/24; C07C323/25
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
111 words
A benzhydryl derivative having the formula ##STR7## wherein each of the groups R 1 , R 2 , and R 3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF 3 , and at least one of the groups R 1 , R 2 , and R 3 is a halogen or CF 3 ; lower alkyl is an alkyl group selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, sec-butyl and tert-butyl; R 4 represents hydrogen or methyl; n is 2, 3, or 4; m is 1, 2, or 3; and X represents S; or its pharmaceutically acceptable salts.
Claim 2
Dependent Claim
111 words
A benzhydryl derivative having the formula ##STR7## wherein each of the groups R 1 , R 2 , and R 3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF 3 , and at least one of the groups R 1 , R 2 , and R 3 is a halogen or CF 3 ; lower alkyl is an alkyl group selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, sec-butyl and tert-butyl; R 4 represents hydrogen or methyl; n is 2, 3, or 4; m is 1, 2, or 3; and X represents S; or its pharmaceutically acceptable salts.
Claim 3
Dependent Claim
14 words
The benzhydryl derivative according to claim 1, wherein R 3 is CF 3 .
Claim 4
Dependent Claim
16 words
The benzhydryl derivative according to claim 1, wherein n and m are independently 2 or 3.
Claim 5
Dependent Claim
14 words
The benzhydryl derivative according to claim 2, wherein R 3 is CF 3 .
Claim 6
Dependent Claim
19 words
A pharmaceutical preparation with calmodulin inhibitor properties comprising the benzhydryl derivative of claim 1, admixed with pharmaceutically acceptable auxiliaries.
Claim 7
Dependent Claim
30 words
A method of treating a mammal for angina or ischaemia comprising administering to said mammal a therapeutically effective amount of the pharmaceutical preparation of claim 5 to inhibit calmodulin activity.
References Cited (Backward Citations)
GB1028913A
Cited
US3666811A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-15 | 1996-06-15 | 1996-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-15 | 2000-06-15 | 2000-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-15 | 2004-06-15 | 2004-12-15 | $7700.00 | Window Closed / Lapsed |