US5170192A — Oxygen permeable bifocal contact lenses and their…

Claim 1

Independent Claim 131 words

An oxygen permeable bifocal contact lens having a distance vision portion with one refractive index and a near vision portion with another higher refractive index and a Dk of at least 10, the distance portion forming the major portion of the lens and being formed as a crosslinked copolymer with a refractive index of not more than 1.49 from monomeric materials which include one or more monomers capable of imparting oxygen permeability to the finished lens, and the near vision portion similarly being formed as a crosslinked copolymer from a monomer mixture which includes one or more monomers at a concentration and with a refractive index such that the near vision portion has a refractive index of at least 1.540 including at least one vinyl monomer having substituted aromatic ring structure.

Claim 2

Dependent Claim 131 words

An oxygen permeable bifocal contact lens having a distance vision portion with one refractive index and a near vision portion with another higher refractive index and a Dk of at least 10, the distance portion forming the major portion of the lens and being formed as a crosslinked copolymer with a refractive index of not more than 1.49 from monomeric materials which include one or more monomers capable of imparting oxygen permeability to the finished lens, and the near vision portion similarly being formed as a crosslinked copolymer from a monomer mixture which includes one or more monomers at a concentration and with a refractive index such that the near vision portion has a refractive index of at least 1.540 including at least one vinyl monomer having substituted aromatic ring structure.

Claim 3

Dependent Claim 23 words

An oxygen permeable bifocal contact lens as claimed in claim 1, in which the distance vision portion is formed as an interpenetrating network.

Claim 4

Dependent Claim 24 words

An oxygen permeable bifocal contact lens as claimed in claim 2, in which the near vision portion is also formed as in interpenetrating network.

Claim 5

Dependent Claim 43 words

An oxygen permeable bifocal contact lens as claimed in claim 2, in which the interpenetrating network is formed by polymerizing a mixture of two monomer mixtures, one of which is partially polymerized to a selected relative viscosity before being mixed with the other.

Claim 6

Dependent Claim 55 words

An oxygen permeable bifocal contact lens as claimed in claim 4 in which the distance vision portion is formed as an interpenetrating network from two monomer mixtures A and B and the composition is selected so that Mixture A contains 10% to 90% (w/w) of the total monomer formula weight, the balance being Mixture B.

Claim 7

Dependent Claim 30 words

An oxygen permeable bifocal contact lens as claimed in claim 5 where Mixture A contains 50% to 95% of the total monomer formula weight, and the balance is Mixture B.

Claim 8

Dependent Claim 64 words

An oxygen permeable bifocal contact lens as claimed in claim 4 in which the near vision portion is formed as an interpenetrating network with a refractive index of at least 1.540 from two monomer mixtures C and D and the resultant composition is selected so that Mixture C contains 10 to 90% of the total monomer formula weight, and the balance is Mixture D.

Claim 9

Dependent Claim 215 words

An oxygen permeable bifocal contact lens as claimed in claim 5 in which the total monomer content of mixtures A and B is selected from: a) 0 to 30% of an alkyl acrylate having the formula: ##STR6## where R=H or a monovalent organic radical having not more than 7 carbon atoms and R'=a monovalent organic radical having up to 20 carbon atoms, b) 0 to 35% of a fluoroacrylate monomer having the formula: ##STR7## where R=H or a monovalent organic radical having not more than 7 carbon atoms; A=H or E and E is a fluorinated monovalent radical having no more than 20 carbon atoms, c) 10 to 70% of a silicone acrylate of the general formula: ##STR8## where R=H or monovalent organic radical having from 1 to 7 carbon atoms or Z; Y is a monovalent organic radical having from 1 to 7 carbon atoms or Z; and ##STR9## where R1, R2, and R3 are the same or different monovalent organic radicals having from 1 to 7 carbon atoms and R4 is OH or a monovalent organic radical having from 1 to 7 carbon atoms; and k=0-1; m=1-3; n=1-5; and p=1-3, d) from 0.1 to 20% of at least one crosslinking agent, e) from 1 to 10% of a polymerizable vinyl hydrophilic wetting agent.

Claim 10

Dependent Claim 124 words

An oxygen permeable bifocal contact lens as claimed in claim 7 in which the total monomer content of Mixtures C and D is selected from: a) from 30 to 90% of at least one polymerizable vinyl monomer having a refractive index of at least 1.540 and having a substituted aromatic ring structure, b) from 1 to 60 of an acrylate having the formula: ##STR10## where R=H or a monovalent organic radical having not more than 7 carbon atoms and R' is a monovalent organic radical having up to 20 carbon atoms, c) from 0.1 to 15% of a polymerizable polyvinyl crosslinking agent, d) from 0 to 2% of a polymerizable vinyl silane coupling agent, e) from 0.1 to 3.0% of a vinyl polymerization initiator.

Claim 11

Dependent Claim 30 words

An oxygen permeable bifocal contact lens as claimed in claim 9 in which the polymerizable vinyl monomer having a refractive index of at least 1.540 comprises one or more carbazoles.

Claim 12

Dependent Claim 29 words

An oxygen permeable bifocal contact lens as claimed in claim 10 in which one or more carbazoles are selected from the group consisting of N-vinyl carbazole, 3-(N-carbazoyl) propyl acrylate.

Claim 13

Dependent Claim 45 words

An oxygen permeable bifocal contact lens as claimed in claim 9 in which at least one polymerizable vinyl monomer having a refractive index of at least 1.540 is selected from the group consisting of 2-(N-phenothiazinyl) ethyl acrylate, p-t-butylstyrene, vinyl naphthalene, and phenyl and benzyl methacrylates.

Claim 14

Dependent Claim 25 words

An oxygen permeable bifocal contact lens as claimed in claim 1 in which the distance vision portion of the lens surrounds the near vision portion.

Claim 15

Dependent Claim 43 words

An oxygen permeable bifocal contact lens as claimed in claim 3, in which the interpenetrating network is formed by polymerizing a mixture of two monomer mixtures, one of which is partially polymerized to a selected relative viscosity before being mixed with the other.

Claim 16

Dependent Claim 55 words

An oxygen permeable bifocal contact lens as claimed in claim 14 in which the distance vision portion is formed as an interpenetrating network from two monomer mixtures A and B and the composition is selected so that Mixture A contains 10% to 90% (w/w) of the total monomer formula weight, the balance being Mixture B.

Claim 17

Dependent Claim 30 words

An oxygen permeable bifocal contact lens as claimed in claim 15 where Mixture A contains 50% to 95% of the total monomer formular weight, and the balance is Mixture B.

Claim 18

Dependent Claim 215 words

An oxygen permeable bifocal contact lens as claimed in claim 15 in which the total monomer content of mixtures A and B is selected from: a) 0 to 30% of an alkyl acrylate having the formula: ##STR11## where R=H or a monovalent organic radical having not more than 7 carbon atoms and R'=a monovalent organic radical having up to 20 carbon atoms, b) 0 to 35% of a fluoroacrylate monomer having the formula: ##STR12## where R=H or a monovalent organic radical having not more than 7 carbon atoms; A=H or E and E is a fluorinated monovalent radical having no more than 20 carbon atoms, c) 10 to 70% of a silicone acrylate of the general formula: ##STR13## where R=H or monovalent organic radical having from 1 to 7 carbon atoms or Z; Y is a monovalent organic radical having from 1 to 7 carbon atoms or Z; and ##STR14## where R1, R2, and R3 are the same or differnt monovalent organic radicals having from 1 to 7 carbon atoms and R4 is OH or a monovalent organic radical having from 1 to 7 carbon atoms; and k=0-1; m=1-3; n=1-5; and p=1-3, d) from 0.1 to 20% of at least one crosslinking agent, e) from 1 to 10% of a polymerizable vinyl hydrophilic wetting agent.

Claim 19

Dependent Claim 215 words

An oxygen permeable bifocal contact lens as claimed in claim 6 in which the total monomer content of mixtures A and B is selected from: a) 0 to 30% of an alkyl acrylate having the formula: ##STR15## where R=H or a monovalent organic radical having not more than 7 carbon atoms and R'=a monovalent organic radical having up to 20 carbon atoms, b) 0 to 35% of a fluoroacrylate monomer having the formula: ##STR16## where R=H or a monovalent organic radical having not more than 7 carbon atoms; A=H or E and E is a fluorinated monovalent radical having no more than 20 carbon atoms, c) 10 to 70% of a silicone acrylate of the general formula: ##STR17## where R=H or monovalent organic radical having from 1 to 7 carbon atoms or Z; Y is a monovalent organic radical having from 1 to 7 carbon atoms or Z; and ##STR18## where R1, R2, and R3 are the same or different monovalent organic radicals having from 1 to 7 carbon atoms and R4 is OH or a monovalent organic radical having from 1 to 7 carbon atoms; and k=0-1; m=1-3; n=1-5; and p=1-3, d) from 0.1 to 20% of at least one crosslinking agent, e) from 1 to 10% of a polymerizable vinyl hydrophilic wetting agent.

Claim 20

Dependent Claim 215 words

An oxygen permeable bifocal contact lens as claimed in claim 16 in which the total monomer content of mixtures A and B is selected from: a) 0 to 30% of an alkyl acrylate having the formula: ##STR19## where R=H or a monovalent organic radical having not more than 7 carbon atoms and R'=a monovalent organic radical having up to 20 carbon atoms, b) 0 to 35% of a fluoroacrylate monomer having the formula: ##STR20## where R=H or a monovalent organic radical having not more than 7 carbon atoms; A=H or E and E is a fluorinated monovalent radical having no more than 20 carbon atoms, c) 10 to 70% of a silicone acrylate of the general formula: ##STR21## where R=H or monovalent organic radical having from 1 to 7 carbon atoms or Z; Y is a monovalent organic radical having from 1 to 7 carbon atoms or Z; and ##STR22## where R1, R2, and R3 are the same or different monovalent organic radicals having from 1 to 7 carbon atoms and R4 is OH or a monovalent organic radical having from 1 to 7 carbon atoms; and k=0-1; m=1-3; n=1-5; and p=1-3, d) from 0.1 to 20% of at least one crosslinking agent, e) from 1 to 10% of a polymerizable vinyl hydrophilic wetting agent.

Claim 21

Dependent Claim 131 words

An oxygen permeable bifocal contact lens as claimed in any one of claims 4, 5, 6 or 8 in which the total monomer content of Mixtures C and D is selected from: a) from 30 to 90% of at least one polymerizable vinyl monomer having a refractive index of at least 1.540 and having a substituted aromatic ring structure, b) from 1 to 60 of an acrylate having the formula: ##STR23## where R=H or a monovalent organic radical having not more than 7 carbon atoms and R' is a monovalent organic radical having up to 20 carbon atoms, c) from 0.1 to 15% of a polymerizable polyvinyl crosslinking agent, d) from 0 to 2% of a polymerizable vinyl silane coupling agent, e) from 0.1 to 3.0% of a vinyl polymerization initiator.

Claim 22

Dependent Claim 30 words

An oxygen permeable bifocal contact lens as claimed in claim 20 in which the polymerizable vinyl monomer having a refractive index of at least 1.540 comprises one of more carbazoles.

Claim 23

Dependent Claim 29 words

An oxygen permeable bifocal contact lens as claimed in claim 21 in which one or more carbazoles are selected from the group consisting of N-vinyl carbazole, 3(N-carbazoyl) propyl acrylate.

Claim 24

Dependent Claim 45 words

An oxygen permeable bifocal contact lens as claimed in claim 20 in which at least one polymerizable vinyl monomer having a refractive index of at least 1.540 is selected from the group consisting of 2-(N-phenothiazinyl) ethyl acrylate, p-t-butylstyrene, vinyl naphthalene, and phenyl and benzyl methacrylates.

Claim 25

Independent Claim 124 words

A method of producing an oxygen permeable bifocal contact lens having a near vision portion and a distance vision portion in which the near vision portion is formed in the body of the lens by polymerizing a partially polymerized mixture of interpenetrating network forming comonomers in contact with a surface shaped to leave a recess in the material after both polymerization and removal from contact with the shaped surface, the recess being of the same shape as the desired shape of the near vision portion of the finished lens, and a partially polymerized mixture of interpenetrating network comonomers, including at least one vinyl monomer with refractive index of at least 1.540 and a substituted aromatic ring structure is placed in the recess and polymerized.

Claim 26

Independent Claim 124 words

A method of producing an oxygen permeable bifocal contact lens having a near vision portion and a distance vision portion in which the near vision portion is formed in the body of the lens by polymerizing a partially polymerized mixture of interpenetrating network forming comonomers in contact with a surface shaped to leave a recess in the material after both polymerization and removal from contact with the shaped surface, the recess being of the same shape as the desired shape of the near vision portion of the finished lens, and a partially polymerized mixture of interpenetrating network comonomers, including at least one vinyl monomer with refractive index of at least 1.540 and a substituted aromatic ring structure is placed in the recess and polymerized.

Claim 27

Dependent Claim 55 words

A method of producing a bifocal contact lens as claimed in claim 24 in which the near vision portion is covered with the material used to form the distance vision portion of the lens by polymerizing a further quantity of said distance vision material in contact with the already formed near and distance vision portions.

Claim 28

Dependent Claim 23 words

A method as claimed in claim 25 is which a base curve is cut in the near vision portion before it is covered.

Claim 29

Dependent Claim 52 words

A method as claimed in claim 24, 25, or 26 in which a quantity of the material used to form the distance vision portion is placed in an open topped mold and a recess formed by providing the mold with a cover whose surface contacting the material is the recess forming surface.

Claim 30

Dependent Claim 37 words

The method as claimed in claim 27 in which a lens blank is formed within the open topped mold and the mold is used as a carrier during machining the lens blank to a final lens form.

Claim 31

Dependent Claim 145 words

An oxygen permeable bifocal contact lens with a Dk of at least 10×10 -11 in which the higher index segment is surrounded by an oxygen permeable low index material by forming the lens in a series of steps comprising first forming a preform from low index material in which there is provided a recess, filling the recess with a partially polymerized high index material formed from a monomer mixture which includes at least one vinyl monomer with a refractive index of at least 1.540 and having a substituted aromatic ring structure completing the polymerization of the high index material, and thereafter covering both the low index material and the high index material with further low index material in a partially polymerized form, and finally completing polymerization of the low index material to form a lens blank which is then machined into a bifocal contact lens.

Claim 32

Dependent Claim 145 words

An oxygen permeable bifocal contact lens with a Dk of at least 10×10 -11 in which the higher index segment is surrounded by an oxygen permeable low index material by forming the lens in a series of steps comprising first forming a preform from low index material in which there is provided a recess, filling the recess with a partially polymerized high index material formed from a monomer mixture which includes at least one vinyl monomer with a refractive index of at least 1.540 and having a substituted aromatic ring structure completing the polymerization of the high index material, and thereafter covering both the low index material and the high index material with further low index material in a partially polymerized form, and finally completing polymerization of the low index material to form a lens blank which is then machined into a bifocal contact lens.

Claim 33

Independent Claim 180 words

A method of producing an oxygen permeable bifocal contact lens with a Dk of at least 10×10 -11 by embedding a high refractive index polymer segment within a lens blank which has a substantially lower refractive index than that of the internal segment, the lens blank having been prepared by casting a partially polymerized mixture of low refractive index interpenetrating network forming comonomers including a silicone acrylate monomer against a mold with a protrusion so as to form a recess in the blank and polymerizing to a solid state, the recess being then filled with a relatively high refractive index monomer mixture, which includes at least one vinyl monomer with a refractive index of at least 1.540 and a substituted aromatic ring structure, the polymerization of which is then completed in the recess, a sufficient quantity of partially polymerized low refractive index monomer mixture being next added to completely cover the high refractive index segment, and the resulting composition is cured to form the final bifocal contact lens blank, which is in turn machined to form a bifocal contact lens.

Claim 34

Independent Claim 180 words

A method of producing an oxygen permeable bifocal contact lens with a Dk of at least 10×10 -11 by embedding a high refractive index polymer segment within a lens blank which has a substantially lower refractive index than that of the internal segment, the lens blank having been prepared by casting a partially polymerized mixture of low refractive index interpenetrating network forming comonomers including a silicone acrylate monomer against a mold with a protrusion so as to form a recess in the blank and polymerizing to a solid state, the recess being then filled with a relatively high refractive index monomer mixture, which includes at least one vinyl monomer with a refractive index of at least 1.540 and a substituted aromatic ring structure, the polymerization of which is then completed in the recess, a sufficient quantity of partially polymerized low refractive index monomer mixture being next added to completely cover the high refractive index segment, and the resulting composition is cured to form the final bifocal contact lens blank, which is in turn machined to form a bifocal contact lens.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1995-12-08	1996-06-08	1996-12-08	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1999-12-08	2000-06-08	2000-12-08	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2003-12-08	2004-06-08	2004-12-08	$7700.00	Window Closed / Lapsed

Oxygen permeable bifocal contact lenses and their manufacture

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