US5169842A
Expired / Lapsed
US
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Oligophosphates with an antiviral action
Assignee: Bayer AG
•
Filing: 1991-05-09
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Granted: 1992-12-08
•
Expires: 2011-05-09
Abstract
Abstract Novel oligophosphates with an antiviral action of the formula ##STR1## in which n is 3-50, B and E are, independently of one another, O, S or NH, A is O, NR or S, D is O, S or NR 2 , in which independently each R is H, alkyl, aralkyl or aryl, and X is --(CH.sub.2).sub.m --, ##STR2##
Inventors
- 👤 Antonius Lobberding
- 👤 Axel C. Heitmann
- 👤 Burkhard Mielke
- 👤 Udo Stropp
- 👤 Axel Kretschmer
- 👤 Helga Rubsamen-Waigmann
- 👤 Lothar Biesert
- 👤 Haryadi Suhartono
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 08:43
CPC Classifications
C; C08; C08G; C08G79/00; C08G79/02; A; A61; A61P; A61P31/00; A61P31/12
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
222 words
An acylic oligophosphate of the formula ##STR12## in which n is 3-50, B and E are O, A is O or S, D is O, S or NR 2 if A=O in which independently each R is H, alkyl, aralkyl or aryl, and X either denotes --(CH 2 ) m --in which m represents 1 to 5, or ##STR13## in which R 1 , R 2 and R 3 , each independently of one another, is H, --CH 3 , --CH 2 CH 3 , --CH(CH 3 ) 2 , phenyl, benzyl or --CH 2 OCH 3 , or R 2 can also be F or Cl, and m is 0 to 5, ##STR14## in which each R 5 represents, independently of one another, H, CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , benzyl, phenyl, --CH 2 OCH 3 , O-aryl, O-alkyl, NH-aryl or NH-alkyl, and Y is O, S or CH 2 , and Z is --(CHR 6 )p, where p is 0 to 3, and R 6 can have the same meanings as R 5 , or ##STR15## in which Y 1 is O, S or CH 2 , W is --(CH--R 7 ) i -- where i is zero or one, and R 7 is H, OH, alkyl, aryl, O-alkyl, O-aryl, NH-alkyl or NH-aryl.
Claim 2
Dependent Claim
222 words
An acylic oligophosphate of the formula ##STR12## in which n is 3-50, B and E are O, A is O or S, D is O, S or NR 2 if A=O in which independently each R is H, alkyl, aralkyl or aryl, and X either denotes --(CH 2 ) m --in which m represents 1 to 5, or ##STR13## in which R 1 , R 2 and R 3 , each independently of one another, is H, --CH 3 , --CH 2 CH 3 , --CH(CH 3 ) 2 , phenyl, benzyl or --CH 2 OCH 3 , or R 2 can also be F or Cl, and m is 0 to 5, ##STR14## in which each R 5 represents, independently of one another, H, CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , benzyl, phenyl, --CH 2 OCH 3 , O-aryl, O-alkyl, NH-aryl or NH-alkyl, and Y is O, S or CH 2 , and Z is --(CHR 6 )p, where p is 0 to 3, and R 6 can have the same meanings as R 5 , or ##STR15## in which Y 1 is O, S or CH 2 , W is --(CH--R 7 ) i -- where i is zero or one, and R 7 is H, OH, alkyl, aryl, O-alkyl, O-aryl, NH-alkyl or NH-aryl.
Claim 3
Dependent Claim
14 words
An acrylic oligohosphate according to claim 1, in which n is 10 to 30.
Claim 4
Dependent Claim
14 words
An acrylic oligophosphate according to claim 1, in which n is 18 to 28.
Claim 5
Dependent Claim
7 words
An acrylic oligophosphate of the formula ##STR16##
Claim 6
Dependent Claim
7 words
An acrylic oligophosphate of the formula ##STR16##
Claim 7
Dependent Claim
7 words
An acrylic oligophosphate of the formula ##STR17##
Claim 8
Dependent Claim
7 words
An acrylic oligophosphate of the formula ##STR17##
Claim 9
Dependent Claim
7 words
An acrylic oligophosphate of the formula ##STR18##
Claim 10
Dependent Claim
7 words
An acrylic oligophosphate of the formula ##STR18##
Claim 11
Dependent Claim
7 words
An acrylic oligophosphate of the formula ##STR19##
Claim 12
Dependent Claim
7 words
An acrylic oligophosphate of the formula ##STR19##
Claim 13
Dependent Claim
33 words
A composition having antiviral action against HIV 1 and HIV 2 viruses comprising an antivirally effective amount of an oligophosphate and a pharmaceutically acceptable diluent wherein the oligophosphate wherein the oligophosphate is ##STR20##
Claim 14
Dependent Claim
33 words
A composition having antiviral action against HIV 1 and HIV 2 viruses comprising an antivirally effective amount of an oligophosphate and a pharmaceutically acceptable diluent wherein the oligophosphate wherein the oligophosphate is ##STR20##
Claim 15
Independent Claim
36 words
A method of combating the HIV 1 or HIV 2 virus in a patient in need thereof which comprises administering to such a patient an antivirally effective amount of an oligophosphate wherein the oligophosphate is ##STR21##
Claim 16
Independent Claim
36 words
A method of combating the HIV 1 or HIV 2 virus in a patient in need thereof which comprises administering to such a patient an antivirally effective amount of an oligophosphate wherein the oligophosphate is ##STR21##
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