US5169637A
Expired / Lapsed
US
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Stable plurilamellar vesicles
Assignee: Elan Pharmaceuticals LLC
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Filing: 1991-04-02
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Granted: 1992-12-08
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Expires: 2011-04-02
Abstract
Abstract A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the emunization of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.
Inventors
- 👤 Robert P. Lenk
- 👤 Michael W. Fountain
- 👤 Andrew S. Janoff
- 👤 Mircea C. Popescu
- 👤 Steven J. Weiss
- 👤 Richard S. Ginsberg
- 👤 Marc J. Ostro
- 👤 Sol M. Gruner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 00:09
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
52 words
Stable plurilamellar vesicles comprising a plurality of lipid bilayers enclosing aqueous compartments containing at least one entrapped solute, the concentration of such solute in each compartment being substantially equal to the concentration of solute used to prepare the lipid vesicle, in which at least one antimicrobial agent is entrapped within the vesicles.
Claim 2
Dependent Claim
52 words
Stable plurilamellar vesicles comprising a plurality of lipid bilayers enclosing aqueous compartments containing at least one entrapped solute, the concentration of such solute in each compartment being substantially equal to the concentration of solute used to prepare the lipid vesicle, in which at least one antimicrobial agent is entrapped within the vesicles.
Claim 3
Dependent Claim
29 words
The stable plurilamellar vesicles of claim 1 wherein said antimicrobial agent is selected from the group consisting of beta-lactam antibiotics, tetracycline antibiotics, aminoglycoside antibiotics, macrolide antibiotics, and polymyxin antibiotics.
Claim 4
Dependent Claim
24 words
The stable plurilamellar vesicles of claim 2 wherein said antimicrobial agent is a beta-lactam antibiotic selected from the group consisting of penicillins and cephalosporins.
Claim 5
Dependent Claim
27 words
The stable plurilamellar vesicles of claim 2 wherein said antimicrobial agent is an aminoglycoside antibiotic selected from the group consisting of dihydrostreptomycin, streptomycin, gentamicin, kanamycin, and neomycin.
Claim 6
Dependent Claim
13 words
The stable plurilamellar vesicles of claim 4 wherein said aminoglycoside antibiotic is streptomycin.
Claim 7
Dependent Claim
13 words
The stable plurilamellar vesicles of claim 4 wherein said aminoglycoside antibiotic is gentamicin.
Claim 8
Independent Claim
62 words
A method of treating infection in an animal, said method comprising administering a therapeutically effective amount of an antimicrobial agent contained in stable plurilamellar vesicles comprising a plurality of lipid bilayers enclosing aqueous compartments containing at least one entrapped solute, the concentration of such solute in each compartment being substantially equal to the concentration of solute used to prepared the lipid vesicle.
Claim 9
Independent Claim
62 words
A method of treating infection in an animal, said method comprising administering a therapeutically effective amount of an antimicrobial agent contained in stable plurilamellar vesicles comprising a plurality of lipid bilayers enclosing aqueous compartments containing at least one entrapped solute, the concentration of such solute in each compartment being substantially equal to the concentration of solute used to prepared the lipid vesicle.
Claim 10
Dependent Claim
10 words
The method of claim 7 wherein the infection is intracellular.
Claim 11
Dependent Claim
31 words
The method of claim 7 wherein the infection is Brucella spp., Mycobacterium spp., Salmonella spp., Listeria spp., Francisella spp., Histoplasma spp., Corynebacterium spp., Coccidioides spp., Pseudomonas spp., or lymphocytic choriomeningitis virus.
Claim 12
Dependent Claim
27 words
The method of claim 7 wherein said antimicrobial agent is selected from the group consisting of beta-lactam antibiotics, tetracycline antibiotics, aminoglycoside antibiotics, macrolide antibiotics, and polymyxin antibiotics.
Claim 13
Dependent Claim
25 words
The method of claim 10 wherein said antimicrobial agent is an aminoglycoside antibiotic selected from the group consisting of dihydrostreptomycin, streptomycin, gentamicin, kanamycin, and neomycin.
Claim 14
Dependent Claim
31 words
The method of claim 11 wherein the infection is Brucella spp., Mycobacterium spp., Salmonella spp., Listeria spp., Francisella spp., Histoplasma spp., Corynebacterium spp., Coccidioides spp., Pseudomonas spp., or lymphocytic choriomeningitis virus.
Claim 15
Dependent Claim
10 words
The method of claim 12 wherein the infection is intracellular.
Claim 16
Dependent Claim
11 words
The method of claim 13 wherein the aminoglycoside antibiotic is gentamicin.
Claim 17
Dependent Claim
11 words
The method of claim 14 wherein the infection is Mycobacterium spp.
Claim 18
Dependent Claim
11 words
The method of claim 13 wherein the aminoglycoside antibiotic is streptomycin.
Claim 19
Dependent Claim
11 words
The method of claim 16 wherein the infection is Brucella spp.
References Cited (Backward Citations)
US4522803A
Cited
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