US5166195A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
Assignee: Ionis Pharmaceuticals Inc
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Filing: 1990-05-11
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Granted: 1992-11-24
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Expires: 2010-05-11
Abstract
Abstract Methods for modulating the expression of the HIV tat gene are disclosed comprising contacting tat RNA with oligonucleotide or oligonucleotide analog which can bind with at least a portions of the RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind to portions of the tat RNA which are of significance to the expression of the gene coding for said RNA. In accordance with a preferred embodiment, methods of treatment of human immunodeficiency virus are disclosed.
Inventors
- 👤 David J. Ecker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 04:47
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/113; C12N15/1131; C12N15/1132; A; A61; A61P; A61P31/00; A61P31/12; C07; C07K; C07K14/00; C07K14/005; A61K; A61K38/00; C12N2310/00; C12N2310/30; C12N2310/31; C12N2310/315; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/16011; C12N2740/16311; C12N2740/16322
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
18 words
An oligonucleotide analog with a phosphorothioate backbone having a nucleotide sequence selected from the group consisting of: ##STR2##
Claim 2
Dependent Claim
18 words
An oligonucleotide analog with a phosphorothioate backbone having a nucleotide sequence selected from the group consisting of: ##STR2##
Claim 3
Dependent Claim
15 words
A pharmaceutical composition comprising the oligonucleotide analog of claim 1 in a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
US4959463A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-24 | 1996-05-25 | 1996-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-24 | 2000-05-25 | 2000-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-24 | 2004-05-25 | 2004-11-24 | $7700.00 | Window Closed / Lapsed |